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Powdered pharmaceutical formulations having improved dispersibility 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-009/14
출원번호 US-0945872 (1998-03-17)
국제출원번호 PCT/US96/05265 (1996-04-15)
§371/§102 date 19980317 (19980317)
국제공개번호 WO-9632096 (1996-10-17)
발명자 / 주소
  • Eljamal Mohammad,LBX
  • Patton John S.
  • Foster Linda
  • Platz Robert M.
출원인 / 주소
  • Inhale Therapeutic Systems
대리인 / 주소
    Evans
인용정보 피인용 횟수 : 72  인용 특허 : 2

초록

Dispersibility of a respirable powder, administrable by inhalation, is increased by including a pharmaceutically acceptable water-soluble polypeptide.

대표청구항

[ What is claimed is:] [1.] A method of preparing a spray-dried, dispersible powdered pharmaceutical composition, comprising:spray-drying a homogeneous aqueous mixture comprising a pharmaceutically-acceptable excipient, a dispersibility-enhancing, physiologically-acceptable, water-soluble polypeptid

이 특허에 인용된 특허 (2)

  1. Platz Robert M. (Half Moon Bay CA) Ip Anna (Moorpark CA) Whitham Clyde L. (Montara CA), Process for preparing micronized polypeptide drugs.
  2. Pitt Colin G. (Thousand Oaks CA) Platz Robert M. (Half Moon Bay CA), Pulmonary administration of erythropoietin.

이 특허를 인용한 특허 (72)

  1. Cox, Kenneth A.; Beane, Timothy Paul; Sweeney, William R., Aerosol generator and methods of making and using an aerosol generator.
  2. Cox, Kenneth A.; Beane, Timothy Paul; Sweeney, William R.; Nichols, Walter A.; Sprinkel, Jr., F. Murphy, Aerosol generator and methods of making and using an aerosol generator.
  3. Cox,Kenneth A.; Beane,Timothy Paul; Sweeney,William R.; Nichols,Walter A.; Sprinkel, Jr.,F. Murphy, Aerosol generator and methods of making and using an aerosol generator.
  4. Sprinkel, Jr., F. Murphy; Nichols, Walter A., Aerosol generator having a multiple path heater arrangement and method of use thereof.
  5. Sherwood, Timothy S.; Sowers, Scott A.; Reddy, Sirisha P.; Sprinkel, Jr., F. Murphy; Cox, Kenneth A.; Nichols, Walter A., Aerosol generator having heater arranged to vaporize fluid in fluid passage between bonded layers of laminate.
  6. Sprinkel, Jr., F. Murphy; Nichols, Walter A.; Cox, Kenneth A.; Sherwood, Timothy S.; Sowers, Scott A.; Washington, Zelita R.; Reddy, Sirisha, Aerosol generator having heater in multilayered composite and method of use thereof.
  7. Sharpe, David E.; Felter, John L., Aerosol generator having inductive heater and method of use thereof.
  8. Kenneth A. Cox ; Walter A. Nichols ; F. Murphy Sprinkel, Jr. ; Douglas D. McRae ; William R. Sweeney, Aerosol generator having multiple heating zones and methods of use thereof.
  9. Cox,Kenneth A.; Nichols,Walter A.; Sprinkel, Jr.,F. Murphy; McRae,Douglas D.; Sweeney,William R., Aerosol generator having temperature controlled heating zone and method of use thereof.
  10. Nichols, Walter A.; Sprinkel, Jr., F. Murphy, Disposable aerosol generator system and methods for administering the aerosol.
  11. Nichols,Walter A.; Sprinkel, Jr.,F. Murphy, Disposable aerosol generator system and methods for administering the aerosol.
  12. Nichols,Walter A.; Sprinkel, Jr.,F. Murphy, Disposable inhaler system.
  13. Nichols,Walter A.; Sprinkel, Jr.,F. Murphy, Disposable inhaler system.
  14. Yadidi, Kambiz, Dry powder formulations and methods of use.
  15. Yadidi, Kambiz, Dry powder formulations for inhalation.
  16. Yadidi, Kambiz, Dry powder inhaler and methods of use.
  17. Yadidi, Kambiz, Dry powder inhaler and methods of use.
  18. Nichols, Walter A.; Cox, Kenneth A.; Nguyen, Tung Tien, Dual capillary fluid vaporizing device.
  19. Nichols, Walter A.; Cox, Kenneth A.; Nguyen, Tung Tien, Dual capillary fluid vaporizing device.
  20. Tarara, Thomas E.; Weers, Jeffry G.; Kabalnov, Alexey; Schutt, Ernest G.; Dellamary, Luis A., Engineered particles and methods of use.
  21. Tarara,Thomas E.; Weers,Jeffry G.; Kabalnov,Alexey; Schutt,Ernest G.; Dellamary,Luis A., Engineered particles and methods of use.
  22. Faison, Jr.,Gene G.; Gupta,Rajiv; McRae,Douglas D.; Nichols,Walter A., Fluid vaporizing device having controlled temperature profile heater/capillary tube.
  23. Nichols, Walter A.; Cox, Kenneth A.; McRae, Douglas D.; Nguyen, Tung Tien, Fluid vaporizing device having controlled temperature profile heater/capillary tube.
  24. Tarara, Thomas E.; Weers, Jeffry G.; Eldon, Michael A.; Narashimhan, Rangachari; Clark, Andrew, Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use.
  25. Lipp, Michael W.; Batycky, Richard P.; Caponetti, Giovanni, Formulation for spray-drying large porous particles.
  26. Truong Le,Vu; Scherer,Tom, High pressure spray-dry of bioactive materials.
  27. Tsutsui, Tatsuo, Intranasal delivery devices.
  28. Byron,Peter R.; Hindle,Michael, Method and apparatus for generating an aerosol.
  29. Hindle, Michael; Byron, Peter R.; Gupta, Rajiv, Method for generating an aerosol with a predetermined and/or substantially monodispersed particle size distribution.
  30. Patton, John S.; Foster, Linda S.; Platz, Robert M., Methods and compositions for pulmonary delivery of insulin.
  31. Hindle, Michael; Byron, Peter R.; Hong, John N., Mouthpiece entrainment airflow control for aerosol generators.
  32. Edwards, David A.; Hrkach, Jeffrey S., Particles for inhalation having sustained release properties.
  33. Batycky,Richard P.; Edwards,David A.; Lipp,Michael M., Particulate compositions for pulmonary delivery.
  34. Batycky,Richard P.; Edwards,David A.; Lipp,Michael M., Particulate compositions for pulmonary delivery.
  35. Vehring, Reinhard; Miller, Danforth P.; Lechuga-Ballesteros, David, Pharmaceutical formulation comprising a water-insoluble active agent.
  36. Vehring, Reinhard; Miller, Danforth P; Lechuga-Ballesteros, David, Pharmaceutical formulation comprising a water-insoluble active agent.
  37. Weers, Jeffry G.; Tarara, Thomas E.; Dellamary, Luis A.; Riess, Jean G.; Schutt, Ernest G., Phospholipid-based powders for drug delivery.
  38. Weers, Jeffry G; Tarara, Thomas E; Dellamary, Luis A; Riess, Jean G; Schutt, Ernest G, Phospholipid-based powders for drug delivery.
  39. Bossard, Mary J.; Roczniak, Steven O.; Zappe, Harold; Wang, Yujun; Zhang, Ping; Sheng, Dawei; Jude-Fishburn, C. Simone; Minamitani, Elizabeth Louise; Liu, Xiaofeng; Moskowitz, Haim; Fry, Dennis G.; Ali, Cherie F.; Brew, Christine Taylor, Polymer conjugates of therapeutic peptides.
  40. Truong Le,Vu; Pham,Binh, Preservation of bioactive materials by spray drying.
  41. Truong-Le, Vu; Pham, Binh, Preservation of bioactive materials by spray drying.
  42. Truong-Le, Vu; Pham, Binh, Preservation of bioactive materials by spray drying.
  43. Truong-Le, Vu; Pham, Binh, Preservation of bioactive materials by spray drying.
  44. Patton,John S., Pulmonary delivery of active fragments of parathyroid hormone.
  45. Tarara, Thomas E.; Weers, Jeffry G.; Venthoye, Geraldine, Pulmonary delivery of aminoglycoside.
  46. Tarara, Thomas E; Weers, Jeffry G; Venthoye, Maria Geraldine, Pulmonary delivery of aminoglycoside.
  47. Tarara, Thomas E.; Weers, Jeffrey G.; Kabalnov, Alexey; Schutt, Ernest G.; Dellamary, Luis A., Pulmonary delivery particles comprising an active agent.
  48. Weers, Jeffry G.; Schutt, Ernest G.; Dellamary, Luis A.; Tarara, Thomas E.; Kabalnov, Alexey, Respiratory dispersion for metered dose inhalers comprising perforated microstructures.
  49. Berndl, Gunther; Breitenbach, Jörg; Heger, Robert; Stadler, Michael; Wilke, Peter; Rosenberg, Jörg, Self-emulsifying active substance formulation and use of this formulation.
  50. Berndl, Gunther; Breitenbach, Jörg; Heger, Robert; Stadler, Michael; Wilke, Peter; Rosenberg, Jörg, Self-emulsifying active substance formulation and use of this formulation.
  51. Roser, Bruce J.; Kampinga, Jaap; Colaco, Camilo; Blair, Julian, Solid dose delivery vehicle and methods of making same.
  52. Roser, Bruce J.; Kampinga, Jaap; Colaco, Camilo; Blair, Julian, Solid dose delivery vehicle and methods of making same.
  53. Roser, Bruce J.; Kampinga, Jaap; Colaco, Camilo; Blair, Julian, Solid dose delivery vehicle and methods of making same.
  54. Rosenberg, Jeorg; Reinhold, Ulrich; Liepold, Bernd; Berndl, Gunther; Breitenbach, Joerg; Alani, Laman; Ghosh, Soumojeet, Solid pharmaceutical dosage form.
  55. Rosenberg, Joerg; Reinhold, Ulrich; Liepold, Bernd; Berndl, Gunther; Breitenbach, Joerg; Alani, Laman; Ghosh, Soumojeet, Solid pharmaceutical dosage form.
  56. Rosenberg, Joerg; Reinhold, Ulrich; Liepold, Bernd; Berndl, Gunther; Breitenbach, Joerg; Alani, Laman; Ghosh, Soumojeet, Solid pharmaceutical dosage form.
  57. Rosenberg, Joerg; Reinhold, Ulrich; Liepold, Bernd; Berndl, Gunther; Breitenbach, Joerg; Alani, Laman; Ghosh, Soumojeet, Solid pharmaceutical dosage form.
  58. Rosenberg, Joerg; Reinhold, Ulrich; Liepold, Bernd; Berndl, Gunther; Breitenbach, Joerg; Alani, Laman; Ghosh, Soumojeet, Solid pharmaceutical dosage form.
  59. Rosenberg, Jöerg; Reinhold, Ulrich; Liepold, Bernd; Berndl, Gunther; Breitenbach, Jörg; Alani, Laman L.; Ghosh, Soumojeet, Solid pharmaceutical dosage formulation.
  60. Truong-Le, Vu; Ohtake, Satoshi; Martin, Russell Andrew; Pham, Binh V.; Yee, Luisa, Sonic low pressure spray drying.
  61. Truong-Le, Vu; Ohtake, Satoshi; Martin, Russell Andrew; Pham, Binh V.; Yee, Luisa, Sonic low pressure spray drying.
  62. Truong-Le, Vu; Pham, Binh V.; Carpenter, John F.; Randolph, Theodore W.; Seid, Robert, Spray freeze dry of compositions for pulmonary administration.
  63. Weers, Jeffry G.; Schutt, Ernest G.; Dellamary, Luis; Tarara, Thomas E.; Kabalnov, Alexey, Stabilized preparations for use in metered dose inhalers.
  64. Dellamary, Luis A.; Reiss, Jean; Schutt, Ernest G.; Weers, Jeffry G.; Tarara, Thomas E., Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery.
  65. Dellamary, Luis A.; Riess, Jean; Schutt, Ernest G.; Weers, Jeffry G.; Tarara, Thomas E., Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use.
  66. Dellamary, Luis A; Riess, Jean; Schutt, Ernest G; Weers, Jeffry G; Tarara, Thomas E, Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use.
  67. Edwards, David A.; Hrkach, Jeffrey S., Stable spray-dried protein formulations.
  68. Sievers, Robert E.; Sellers, Scott P.; Carpenter, John F., Supercritical fluid-assisted nebulization and bubble drying.
  69. Marc Pellet FR; Chantal Roume FR, Sustained release compositions and the process for their preparation.
  70. Batycky,Richard P.; Lipp,Michael M.; Niven,Ralph W., Use of simple amino acids to form porous particles.
  71. Batycky, Richard P.; Lipp, Michael M.; Niven, Ralph W., Use of simple amino acids to form porous particles during spray drying.
  72. Walter A. Nichols, Vapor driven aerosol generator and method of use thereof.
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