초록

Sulfurpentafluorophenylpyrazoles of formula I are highly potent against flea and tick infestations in animals. The compounds may be formulated to provide products with long duration of action and low potential for inducing vomition and other adverse reactions in treated animals.

대표청구항 ▼

[ What is claimed is:] [1.] A method for controlling ectoparasitic infestation in a companion animal which comprises administering to said animal a therapeutically effective amount of a compound of formula I: [ STR 5 ] wherein R.sup.1 is hydrogen, halogen, or a group NR.sup.4 R.sup.5 ;R.sup.2 is --S

[ What is claimed is:] [1.] A method for controlling ectoparasitic infestation in a companion animal which comprises administering to said animal a therapeutically effective amount of a compound of formula I: [ STR 5 ] wherein R.sup.1 is hydrogen, halogen, or a group NR.sup.4 R.sup.5 ;R.sup.2 is --S(O).sub.n R.sup.6 ;R.sup.3 is --CN or CX--NY.sup.1 .sup.2 ;R.sup.4 and R.sup.5 are independently hydrogen or alkyl;R.sup.6 is haloalkyl;R.sup.7 and R.sup.8 are independently halogen;X is O or S;Y.sup.1 and Y.sup.2 are independently hydrogen, nitro, amino, or alkyl optionally substituted by halogen, cycloalkyl, formyl, C.sub.2-7 alkanoyl, C.sub.4-7 cycloalkylcarbonyl, C.sub.2-7 alkoxycarbonyl, C.sub.2-7 haloalkoxycarbonyl, aryl, or aromatic heterocyclic group; orY.sup.1 and Y.sup.2 together with the nitrogen to which they are attached form an aliphatic heterocyclic group containing from 4 to 8 ring atoms and optionally substituted by halogen or alkyl; orY.sup.1 and Y.sup.2 together form the group.dbd.CHY.sup.3 ; orY.sup.1 is hydrogen and Y.sup.2 is alkoxycarbonyl, alkylcarbonyl, optionally substituted aralkyl, or --S(O)nR.sup.6 ;Y.sup.3 is alkyl, C.sub.2-6 alkenyl, aryl, an aromatic heterocycle, or amino optionally substituted by halogen;n is 0, 1 or 2; or harmaceutically acceptable salt thereof.