초록 ▼

The hydrophilic penetration agents customarily used for the transcutaneous penetration of active ingredients are, surprisingly, found to improve the penetration of antifungal agents through the nails. A corresponding dermatological composition contains at least one antifungal agent chosen, in partic

The hydrophilic penetration agents customarily used for the transcutaneous penetration of active ingredients are, surprisingly, found to improve the penetration of antifungal agents through the nails. A corresponding dermatological composition contains at least one antifungal agent chosen, in particular, from among those of the allylamine family, such as terbinafine-HCl and naftifine-HCl; at least one hydrophilic penetration agent chosen, in particular, from among the glycols, glycol monoethers, glycol diethers, dimethylsulphoxide, caprolactam, dimethylisosorbide, isopropylidene glycerol, dimethylimidazolidinone, ethyl lactate, the polyoxyethylenated C.sub.8 -C.sub.10 glycerides, polyethylene glycol 20 glyceryl laurate and dimethylacetamide; and a water-alcohol solvent medium which dissolves the said antifungal agent(s) and in which the said penetration agent(s) is (or are) at least partially miscible.

대표청구항 ▼

[ We claim:] [1.] A surfactant-free aqueous composition for administration to a nail for the treatment of onychomycoses comprisinga) a pharmaceutically-effective amount of terbinafine hydrochloride;b) water;c) a C.sub.2 -C.sub.8 alkanol; andd) a penetration agent in an amount effective to allow pene

[ We claim:] [1.] A surfactant-free aqueous composition for administration to a nail for the treatment of onychomycoses comprisinga) a pharmaceutically-effective amount of terbinafine hydrochloride;b) water;c) a C.sub.2 -C.sub.8 alkanol; andd) a penetration agent in an amount effective to allow penetration of terbinafine hydrochloride into and through the keratinized ungual layer of the nail, said penetration agent being selected from the group consisting of glycols, glycolmonoethers, glycol diethers, dimethylsulphoxide, caprolactam, dimethylisosorbide, isopropylidene glycerol, dimethylimidazolidinone, N-methyl-pyrrolidone-2, pyrrolidone-2, ethyl lactate, polyoxyethylenated C.sub.8 -C.sub.10 glycerides, polyethylene glycol glyceryl laurate and dimethylacetamide.