초록 ▼

The invention provides hybrid oligonucleotides having phosphorothioate or phosphorodithioate internucleotide linkages, and both deoxyribonucleosides and ribonucleosides or 2'-substituted ribonucleosides. Such hybrid oligonucleotides have superior properties of duplex formation with RNA, nuclease res

The invention provides hybrid oligonucleotides having phosphorothioate or phosphorodithioate internucleotide linkages, and both deoxyribonucleosides and ribonucleosides or 2'-substituted ribonucleosides. Such hybrid oligonucleotides have superior properties of duplex formation with RNA, nuclease resistance, and RNase H activation.

대표청구항 ▼

[ We claim:] [1.] A hybrid antisense oligonucleotide that is complementary to a single stranded target nucleic acid and inhibits expression of the target nucleic acid, the hybrid antisense oligonucleotide comprising at least four contiguous deoxyribonucleotides and at least two 2'-O-methyl-substitut

[ We claim:] [1.] A hybrid antisense oligonucleotide that is complementary to a single stranded target nucleic acid and inhibits expression of the target nucleic acid, the hybrid antisense oligonucleotide comprising at least four contiguous deoxyribonucleotides and at least two 2'-O-methyl-substituted ribonucleotides at the 3'-end of the oligonucleotide, and further comprising one or more phosphorothioate internucleotide linkages.