초록 ▼

Methods and compositions of matter are provided that enable a phased reduction of body iron stores to near a iron deficiency level, and thereafter maintain the body iron stores at that level by reducing further iron accumulation. In a first phase, a patient's body iron stores are reduced to a level

Methods and compositions of matter are provided that enable a phased reduction of body iron stores to near a iron deficiency level, and thereafter maintain the body iron stores at that level by reducing further iron accumulation. In a first phase, a patient's body iron stores are reduced to a level of near iron deficiency by regular periodic phlebotomy or use of pharmacological agents, such as iron chelators, for example, over a period of six to twelve months. In a second phase, ingested iron absorption is controlled using an oral dose, taken at mealtimes, of compound comprising a calcium salt and salts of phytic acid, without or without zinc, or by continuing, less frequent phlebotomy.

대표청구항 ▼

[ What is claimed is:] [1.] A method of reducing and maintaining body iron stores of a patient to a near-iron deficiency level comprising:during a first phase of treatment, reducing iron body stores to a near-iron deficiency level corresponding to a serum ferritin level less than about 40 ng/ml and

[ What is claimed is:] [1.] A method of reducing and maintaining body iron stores of a patient to a near-iron deficiency level comprising:during a first phase of treatment, reducing iron body stores to a near-iron deficiency level corresponding to a serum ferritin level less than about 40 ng/ml and an iron saturation index less than about 15%; andduring a second phase of treatment, maintaining iron body stores at the near-iron deficiency level.