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특허 상세정보

2,3-diketopiperazine derivatives or their salts

특허상세정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판) A61K-031/496    A61K-031/506    C07D-040/306    C07D-040/506    C07D-040/906   
미국특허분류(USC) 514/252.13 ; 514/252.14 ; 514/254.1 ; 544/295 ; 544/376 ; 544/377 ; 544/379
출원번호 US-0182011 (1998-10-29)
우선권정보 JP0336884 (1994-12-27)
발명자 / 주소
출원인 / 주소
대리인 / 주소
    Oblon, Spivak, McClelland, Maier & Neustadt, P.C.
인용정보 피인용 횟수 : 53  인용 특허 : 2
초록

General formula [ STR 1 ] wherein R.sup.1 represents a protected or unprotected amidino group; R.sup.2 represents a hydrogen atom or a carboxyl-protecting group; A represents a substituted or unsubstituted lower alkylene group; B represents --O--, --CONH--, --NHCO-- or --SO.sub.2 NH--; Y represents a substituted or unsubstituted lower alkylene group; and the broken line represents a single bond or a double bond.

대표
청구항

[ What is claimed is:] [1.] A 2,3-diketopiperazine compound represented by the formula, or its pharmaceutically acceptable salt: [ STR 170 ] wherein R.sup.1 represents a protected or unprotected amidino group; R.sup.2 represents a hydrogen atom or a carboxyl protecting group; A represents a lower alkylene group which is substituted by at least one member (A substituents) selected from furyl, pyrimidinyl, thienyl, and wherein said A substituents may be further substituted by at least one member selected from a halogen atom, a lower alkyl group, a lower al...

이 특허를 인용한 특허 피인용횟수: 53

  1. Adamo, Benoit; Polidoro, John M.; Overfield, Dennis; Sahi, Carl R.; Laurenzi, Brendan; Smutney, Chad C.; Kinsey, P. Spencer. Apparatus and method for simulating inhalation efforts. USP2017079706944.
  2. Adamo, Benoit; McLean, Scott; Smutney, Chad C.; Polidoro, John M.; Sahi, Carl R.. Apparatus, system and method for measuring resistance of an inhaler. USP2018059983108.
  3. Hayashi, Kazuya. Arylamidine derivative, salt thereof and antifungal agent containing those. USP2013098536343.
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  6. Richardson, Peter; Baughman, Robert A.; Leone-Bay, Andrea; Costello, Donald. Delivery of active agents. USP2013028372804.
  7. Grant, Marshall L.; Stowell, Grayson W.; Menkin, Paul. Diketopiperazine microparticles with defined specific surface areas. USP2017049630930.
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  9. Leone-Bay, Andrea; Moye-Sherman, Destardi; Wilson, Bryan R.. Diketopiperazine salts for drug delivery and related methods. USP20181110130685.
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  12. Smutney, Chad C.; Adamo, Benoit; Polidoro, John M.; Kinsey, P. Spencer; Overfield, Dennis; Sahi, Carl; Billings, Christine; Marino, Mark T.. Dry powder drug delivery system and methods. USP2017059662461.
  13. Smutney, Chad C.; Kinsey, P. Spencer; Sahi, Carl R.; Adamo, Benoit; Polidoro, John M.; McLean, Scott; Overfield, Dennis; Bryant, Anthony. Dry powder inhaler and system for drug delivery. USP2016059339615.
  14. Smutney, Chad C.; Kinsey, P. Spencer; Sahi, Carl R.; Adamo, Benoit; Polidoro, John M.; McLean, Scott; Overfield, Dennis; Bryant, Anthony; He, Tom; Mann, Alfred. Dry powder inhaler and system for drug delivery. USP2016129511198.
  15. Smutney, Chad C.; Kinsey, P. Spencer; Sahi, Carl R.; Adamo, Benoit; Polidoro, John M.; McLean, Scott; Overfield, Dennis; Kraft, Kelly S.; Somerville, Karla. Dry powder inhaler and system for drug delivery. USP2015119192675.
  16. Smutney, Chad C.; Kinsey, P. Spencer; Sahi, Carl R.; Adamo, Benoit; Polidoro, John M.; McLean, Scott; Overfield, Dennis; Kraft, Kelly S.; Somerville, Karla. Dry powder inhaler and system for drug delivery. USP2016099446133.
  17. Smutney, Chad C.; Kinsey, P. Spencer; Sahi, Carl R.; Adamo, Benoit; Polidoro, John M.; McLean, Scott; Overfiled, Dennis; Bryant, Anthony. Dry powder inhaler and system for drug delivery. USP20190210201672.
  18. Fabio, Karine; Guarneri, Joseph J.; Curley, Kieran; Grant, Marshall L.; Leone-Bay, Andrea. Heat-stable dry powder pharmaceutical compositions and methods. USP2018039925144.
  19. Tamotsu Kodama JP; Masahiro Tojo JP; Masanori Ikeda JP. Hexaazaisowurtzitane derivative and method for producing the same. USP2002106472525.
  20. Grant, Marshall; Menkin, Paul; Stowell, Grayson W.. High capacity diketopiperazine microparticles and methods. USP2016069364436.
  21. Grant, Marshall; Menkin, Paul; Stowell, Grayson W.. High capacity diketopiperazine microparticles and methods. USP20181110130709.
  22. Hokenson, Mark; Oberg, Keith A.. Increasing drug affinity for crystalline microparticle surfaces. USP2016099446001.
  23. Smutney, Chad C.; Leone-Bay, Andrea; Galarza, Jose M.; Munoz, Hector; Martin, George R.; Grant, Marshall L.. Inhalable vaccine compositions and methods. USP20181210159644.
  24. Poole, Trent; Steiner, Solomon S.. Inhalation apparatus. USP2017079700690.
  25. Steiner, Solomon S.; Pohl, Roderike; Li, Ming; Hauser, Robert. Insulin formulations for rapid uptake. USP2015069060927.
  26. Overfield, Dennis; Sahi, Carl R.; Adamo, Benoit; Kinsey, P. Spencer; McLean, Scott; Polidoro, John M.; Smutney, Chad C.. Interactive apparatus and method for real-time profiling of inhalation efforts. USP2016069364619.
  27. Leone-Bay, Andrea; Stowell, Grayson W.; Guarneri, Joseph J.; Carlson, Dawn M.; Grant, Marshall; Smutney, Chad C.. Method and composition for treating migraines. USP2014078785396.
  28. Steiner, Solomon S.; Woods, Rodney J.; Sulner, Joseph W.. Method for delivery of monomeric or dimeric insulin complexed to diketopiperazine microparticles. USP2010017648960.
  29. Steiner, Solomon S.; Feldstein, Robert; Lian, Huiling; Rhodes, Christopher A.; Shen, Gregory S.. Method for drug delivery to the pulmonary system. USP2013038394414.
  30. Wilson, Bryan R.; Grant, Marshall. Method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent. USP2016019241903.
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  35. Oberg, Keith A.; Sulner, Joseph; Grant, Marshall L.. Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents. USP2017089717689.
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  37. Richardson, Peter; Baughman, Robert A.; Costello, Donald. Method of preventing adverse effects by GLP-1. USP2013028377869.
  38. Richardson, Peter; Baughman, Robert A.; Potocka, Elizabeth; Boss, Anders Hasager; Petrucci, Richard. Method of treating diabetes type 2 by administering ultrarapid acting insulin. USP2014018623817.
  39. Steiner, Solomon S.; Woods, Rodney J.; Sulner, Joseph W.. Methods and compositions for delivering peptides. USP2014118889099.
  40. Steiner, Solomon S.; Woods, Rodney J.; Sulner, Joseph W.. Methods and compositions for delivering peptides. USP2013038389470.
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  42. Leone-Bay, Andrea; Houghten, Richard A.; Guarneri, Joseph J.; Stowell, Grayson W.. Methods and compositions for treating pain. USP20190410258664.
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  44. Boss, Anders Hasager; Steiner, Solomon S.; Woods, Rodney J.; Sulner, Joseph W.. Potentiation of glucose elimination. USP2015049006175.
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