초록 ▼

General formula [ STR 1 ] wherein R.sup.1 represents a protected or unprotected amidino group; R.sup.2 represents a hydrogen atom or a carboxyl-protecting group; A represents a substituted or unsubstituted lower alkylene group; B represents --O--, --CONH--, --NHCO-- or --SO.sub.2 NH--; Y represents

General formula [ STR 1 ] wherein R.sup.1 represents a protected or unprotected amidino group; R.sup.2 represents a hydrogen atom or a carboxyl-protecting group; A represents a substituted or unsubstituted lower alkylene group; B represents --O--, --CONH--, --NHCO-- or --SO.sub.2 NH--; Y represents a substituted or unsubstituted lower alkylene group; and the broken line represents a single bond or a double bond.

대표청구항 ▼

[ What is claimed is:] [1.] A 2,3-diketopiperazine compound represented by the formula, or its pharmaceutically acceptable salt: [ STR 170 ] wherein R.sup.1 represents a protected or unprotected amidino group; R.sup.2 represents a hydrogen atom or a carboxyl protecting group; A represents a lower al

[ What is claimed is:] [1.] A 2,3-diketopiperazine compound represented by the formula, or its pharmaceutically acceptable salt: [ STR 170 ] wherein R.sup.1 represents a protected or unprotected amidino group; R.sup.2 represents a hydrogen atom or a carboxyl protecting group; A represents a lower alkylene group which is substituted by at least one member (A substituents) selected from furyl, pyrimidinyl, thienyl, and wherein said A substituents may be further substituted by at least one member selected from a halogen atom, a lower alkyl group, a lower alkoxy group, a protected or unprotected hydroxyl group, a lower alkylenedioxy group, a benzyl group, a benzhydryl group, a trityl group, and a phenethyl group; B represents --O--, --CONH--, --NHCO-- or --SO.sub.2 NH--; Y represents a lower alkylene group which may be substituted by at least one member (Y substituents) selected from a lower alkyl group, a lower alkoxy group, a cycloalkyl group, a phenyl group, a tolyl group, a naphthyl group, a benzyl group, a benzhydryl group, a trityl group, a phenethyl group and a protected or unprotected hydroxyl group, wherein said Y substituents may be further substituted by at least one member selected from a halogen atom, a lower alkyl group, a lower alkoxy group, a protected or unprotected hydroxyl group, a benzyl group, a benzhydryl group, a trityl group, and a phenethyl group; and the broken line represents a single bond or a double bond.