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2,3-diketopiperazine derivatives or their salts

특허상세정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판) A61K-031/496    A61K-031/506    C07D-040/306    C07D-040/506    C07D-040/906   
미국특허분류(USC) 514/252.13 ; 514/252.14 ; 514/254.1 ; 544/295 ; 544/376 ; 544/377 ; 544/379
출원번호 US-0182011 (1998-10-29)
우선권정보 JP0336884 (1994-12-27)
발명자 / 주소
출원인 / 주소
대리인 / 주소
    Oblon, Spivak, McClelland, Maier & Neustadt, P.C.
인용정보 피인용 횟수 : 53  인용 특허 : 2
초록

General formula [ STR 1 ] wherein R.sup.1 represents a protected or unprotected amidino group; R.sup.2 represents a hydrogen atom or a carboxyl-protecting group; A represents a substituted or unsubstituted lower alkylene group; B represents --O--, --CONH--, --NHCO-- or --SO.sub.2 NH--; Y represents a substituted or unsubstituted lower alkylene group; and the broken line represents a single bond or a double bond.

대표
청구항
▼

[ What is claimed is:] [1.] A 2,3-diketopiperazine compound represented by the formula, or its pharmaceutically acceptable salt: [ STR 170 ] wherein R.sup.1 represents a protected or unprotected amidino group; R.sup.2 represents a hydrogen atom or a carboxyl protecting group; A represents a lower alkylene group which is substituted by at least one member (A substituents) selected from furyl, pyrimidinyl, thienyl, and wherein said A substituents may be further substituted by at least one member selected from a halogen atom, a lower alkyl group, a lower al...

이 특허에 인용된 특허 (2)

  1. Ono Satoshi,JPX ; Yamafuji Tetsuo,JPX ; Yamamoto Hirohiko,JPX ; Egawa Hiroyuki,JPX ; Furuta Yousuke,JPX ; Kaga Hidetoshi,JPX. 2,3-diketopiperazine derivatives or their salts. USP1999035877174.
  2. Tanabe Sohei (Higashimurayama JPX) Sato Seiichi (Tokyo JPX) Kyotani Yoshinori (Higashiyamato JPX) Ohta Tomio (Sayama JPX) Uchida Yasumi (Ichikawa JPX). Sulfonamid compound useful for treating cardiovascular disorders. USP1990084948892.

이 특허를 인용한 특허 피인용횟수: 53

  1. Adamo, Benoit; Polidoro, John M.; Overfield, Dennis; Sahi, Carl R.; Laurenzi, Brendan; Smutney, Chad C.; Kinsey, P. Spencer. Apparatus and method for simulating inhalation efforts. USP2017079706944.
  2. Adamo, Benoit; McLean, Scott; Smutney, Chad C.; Polidoro, John M.; Sahi, Carl R.. Apparatus, system and method for measuring resistance of an inhaler. USP2018059983108.
  3. Hayashi, Kazuya. Arylamidine derivative, salt thereof and antifungal agent containing those. USP2013098536343.
  4. Stevenson, John J.; Moye-Sherman, Destardi. Catalysis of diketopiperazine synthesis. USP2017109796688.
  5. Stevenson, John J.; Moye-Sherman, Destardi. Catalysis of diketopiperazine synthesis. USP2016059346766.
  6. Richardson, Peter; Baughman, Robert A.; Leone-Bay, Andrea; Costello, Donald. Delivery of active agents. USP2013028372804.
  7. Grant, Marshall L.; Stowell, Grayson W.; Menkin, Paul. Diketopiperazine microparticles with defined specific surface areas. USP2017049630930.
  8. Grant, Marshall L.; Stowell, Grayson W.; Menkin, Paul. Diketopiperazine microparticles with defined specific surface areas. USP2014078778403.
  9. Leone-Bay, Andrea; Moye-Sherman, Destardi; Wilson, Bryan R.. Diketopiperazine salts for drug delivery and related methods. USP20181110130685.
  10. Leone-Bay, Andrea; Moye-Sherman, Destardi; Wilson, Bryan R.. Diketopiperazine salts for drug delivery and related methods. USP2017069675674.
  11. Smutney, Chad C.; Adamo, Benoit; Laurenzi, Brendan F.; Kinsey, P. Spencer. Dry powder drug delivery system and methods. USP2017109802012.
  12. Smutney, Chad C.; Adamo, Benoit; Polidoro, John M.; Kinsey, P. Spencer; Overfield, Dennis; Sahi, Carl; Billings, Christine; Marino, Mark T.. Dry powder drug delivery system and methods. USP2017059662461.
  13. Smutney, Chad C.; Kinsey, P. Spencer; Sahi, Carl R.; Adamo, Benoit; Polidoro, John M.; McLean, Scott; Overfield, Dennis; Bryant, Anthony. Dry powder inhaler and system for drug delivery. USP2016059339615.
  14. Smutney, Chad C.; Kinsey, P. Spencer; Sahi, Carl R.; Adamo, Benoit; Polidoro, John M.; McLean, Scott; Overfield, Dennis; Bryant, Anthony; He, Tom; Mann, Alfred. Dry powder inhaler and system for drug delivery. USP2016129511198.
  15. Smutney, Chad C.; Kinsey, P. Spencer; Sahi, Carl R.; Adamo, Benoit; Polidoro, John M.; McLean, Scott; Overfield, Dennis; Kraft, Kelly S.; Somerville, Karla. Dry powder inhaler and system for drug delivery. USP2015119192675.
  16. Smutney, Chad C.; Kinsey, P. Spencer; Sahi, Carl R.; Adamo, Benoit; Polidoro, John M.; McLean, Scott; Overfield, Dennis; Kraft, Kelly S.; Somerville, Karla. Dry powder inhaler and system for drug delivery. USP2016099446133.
  17. Smutney, Chad C.; Kinsey, P. Spencer; Sahi, Carl R.; Adamo, Benoit; Polidoro, John M.; McLean, Scott; Overfiled, Dennis; Bryant, Anthony. Dry powder inhaler and system for drug delivery. USP20190210201672.
  18. Fabio, Karine; Guarneri, Joseph J.; Curley, Kieran; Grant, Marshall L.; Leone-Bay, Andrea. Heat-stable dry powder pharmaceutical compositions and methods. USP2018039925144.
  19. Tamotsu Kodama JP; Masahiro Tojo JP; Masanori Ikeda JP. Hexaazaisowurtzitane derivative and method for producing the same. USP2002106472525.
  20. Grant, Marshall; Menkin, Paul; Stowell, Grayson W.. High capacity diketopiperazine microparticles and methods. USP2016069364436.
  21. Grant, Marshall; Menkin, Paul; Stowell, Grayson W.. High capacity diketopiperazine microparticles and methods. USP20181110130709.
  22. Hokenson, Mark; Oberg, Keith A.. Increasing drug affinity for crystalline microparticle surfaces. USP2016099446001.
  23. Smutney, Chad C.; Leone-Bay, Andrea; Galarza, Jose M.; Munoz, Hector; Martin, George R.; Grant, Marshall L.. Inhalable vaccine compositions and methods. USP20181210159644.
  24. Poole, Trent; Steiner, Solomon S.. Inhalation apparatus. USP2017079700690.
  25. Steiner, Solomon S.; Pohl, Roderike; Li, Ming; Hauser, Robert. Insulin formulations for rapid uptake. USP2015069060927.
  26. Overfield, Dennis; Sahi, Carl R.; Adamo, Benoit; Kinsey, P. Spencer; McLean, Scott; Polidoro, John M.; Smutney, Chad C.. Interactive apparatus and method for real-time profiling of inhalation efforts. USP2016069364619.
  27. Leone-Bay, Andrea; Stowell, Grayson W.; Guarneri, Joseph J.; Carlson, Dawn M.; Grant, Marshall; Smutney, Chad C.. Method and composition for treating migraines. USP2014078785396.
  28. Steiner, Solomon S.; Woods, Rodney J.; Sulner, Joseph W.. Method for delivery of monomeric or dimeric insulin complexed to diketopiperazine microparticles. USP2010017648960.
  29. Steiner, Solomon S.; Feldstein, Robert; Lian, Huiling; Rhodes, Christopher A.; Shen, Gregory S.. Method for drug delivery to the pulmonary system. USP2013038394414.
  30. Wilson, Bryan R.; Grant, Marshall. Method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent. USP2016019241903.
  31. Wilson, Bryan R.; Grant, Marshall. Method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent. USP20181110130581.
  32. Hokenson, Mark; Oberg, Keith A.. Method of drug formulation. USP20181210143655.
  33. Hokenson, Mark; Oberg, Keith A.. Method of drug formulation based on increasing the affinity of active agents for crystalline microparticle surfaces. USP2015069066881.
  34. Hokenson, Mark; Oberg, Keith A.. Method of drug formulation based on increasing the affinity of active agents for crystalline microparticle surfaces. USP2015079089497.
  35. Oberg, Keith A.; Sulner, Joseph; Grant, Marshall L.. Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents. USP2017089717689.
  36. Oberg, Keith A.; Sulner, Joseph; Grant, Marshall L.. Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents. USP2016039283193.
  37. Richardson, Peter; Baughman, Robert A.; Costello, Donald. Method of preventing adverse effects by GLP-1. USP2013028377869.
  38. Richardson, Peter; Baughman, Robert A.; Potocka, Elizabeth; Boss, Anders Hasager; Petrucci, Richard. Method of treating diabetes type 2 by administering ultrarapid acting insulin. USP2014018623817.
  39. Steiner, Solomon S.; Woods, Rodney J.; Sulner, Joseph W.. Methods and compositions for delivering peptides. USP2014118889099.
  40. Steiner, Solomon S.; Woods, Rodney J.; Sulner, Joseph W.. Methods and compositions for delivering peptides. USP2013038389470.
  41. Leone-Bay, Andrea; Houghten, Richard A.; Guarneri, Joseph J.; Stowell, Grayson W.. Methods and compositions for treating pain. USP2016019233159.
  42. Leone-Bay, Andrea; Houghten, Richard A.; Guarneri, Joseph J.; Stowell, Grayson W.. Methods and compositions for treating pain. USP20190410258664.
  43. Leone-Bay, Andrea; Houghten, Richard A.; Guarneri, Joseph J.; Stowell, Grayson W.. Methods and compositions for treating pain. USP2017049610351.
  44. Boss, Anders Hasager; Steiner, Solomon S.; Woods, Rodney J.; Sulner, Joseph W.. Potentiation of glucose elimination. USP2015049006175.
  45. Boss, Anders Hasager; Steiner, Solomon S.; Woods, Rodney J.; Sulner, Joseph W.. Potentiation of glucose elimination. USP2017109801925.
  46. Steiner, Solomon S.; Pohl, Roderike. Rapid acting and long acting insulin combination formulations. USP2010057713929.
  47. Steiner, Solomon S.; Pohl, Roderike. Rapid acting and long acting insulin combination formulations. USP2010057718609.
  48. Pohl, Roderike; Steiner, Solomon S.. Rapid acting injectable insulin compositions. USP2015018933023.
  49. Kraft, Kelly Sullivan. Substituted diketopiperazine analogs for use as drug delivery agents. USP20190110172850.
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  52. Kraft, Kelly Sullivan. Substituted diketopiperazine analogs for use as drug delivery agents. USP2017059655850.
  53. Richardson, Peter; Baughman, Robert A.; Potocka, Elizabeth; Boss, Anders Hasager; Petrucci, Richard. Use of ultrarapid acting insulin. USP2018049943571.

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