Crosslinkable macromers bearing initiator groups
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-047/30
C08J-003/28
C08J-007/18
C12N-011/08
출원번호
US-0469976
(1999-12-21)
발명자
/ 주소
Chudzik Stephen J.
Anderson Aron B.
출원인 / 주소
SurModics, Inc.
대리인 / 주소
Fredrikson & Byron, P.A.
인용정보
피인용 횟수 :
82인용 특허 :
21
초록▼
A crosslinkable macromer system that includes two or more polymer-pendent polymerizable groups and one or more polymer-pendent initiator groups. The polymerizable groups and the initiator group(s) can be pendent on the same or different polymeric backbones. The macromer system provides advantages ov
A crosslinkable macromer system that includes two or more polymer-pendent polymerizable groups and one or more polymer-pendent initiator groups. The polymerizable groups and the initiator group(s) can be pendent on the same or different polymeric backbones. The macromer system provides advantages over the use of polymerizable macromers and separate, low molecular weight initiators, including advantages with respect to such properties as nontoxicity, efficiency, and solubility.
대표청구항▼
[ What is claimed is:] [1.] A method of preparing a crosslinkable macromer system comprising the step of preparing one or more polymers providing pendent polymerization and pendent initiator group wherein the system is adapted to be polymerized in order to form a matrix suitable for in vivo applicat
[ What is claimed is:] [1.] A method of preparing a crosslinkable macromer system comprising the step of preparing one or more polymers providing pendent polymerization and pendent initiator group wherein the system is adapted to be polymerized in order to form a matrix suitable for in vivo application, and wherein either:(a) the polymerizable groups and initator group(s) are pendent on different polymers and the initiator groups are independently selected from the group consisting of long wave ultraviolet activatable molecules selected from the group consisting of benzophenone, thioxanthones, and benzoin ethers; visible light activatable molecules selected from the group consisting of ethyl eosin, eosin Y, rose bengal, camphorquinone and erythrosin; and thermally activatable molecules selected from the group consisting of 4,4' azobis(4-cyanopentanoic) acid, and 2,2-azobis(2-(2-imidazolin-2-yl) propane) dihydrochloride, and benzoyl peroxide; and the pendent polymerizable groups are selected from the group consisting of vinyl groups, acrylate groups, methacrylate groups, ethacrylate groups, 2-phenyl acrylate groups, acrylamide groups, methacrylamide groups, itaconate groups, and styrene groups, or(b) the polymerizable groups and the initiator group(s) are pendent on the same polymer and the initiator groups are independently selected from the group consisting of long wave ultraviolet activatable molecules selected from the group consisting of thioxanthones, and benzoin ethers; visible light activatable molecules selected from the group consisting of ethyl eosin, eosin Y, rose bengal, camphorquinone and erythrosin; and thermally activatable molecules selected from the group consisting of 4,4' azobis(4-cyanopentanoic) acid, and 2,2-azobis(2-(2-imidazolin-2-yl) propane) dihydrochloride, and benzoyl peroxide; and the pendent polymerizable groups are selected from the group consisting of vinyl groups, acrylate groups, methacrylate groups, ethacrylate groups, 2-phenyl acrylate groups, acrylamide groups, methacrylamide groups, itaconate groups, and styrene groups; or(c) the polymerizable groups and the initiator group(s) are pendent on the same polymer and the initiator groups are independently selected from the group consisting of long wave ultraviolet activatable molecules selected from the group consisting of benzophenone, thioxanthones, and benzoin ethers; visible light activatable molecules selected from the group consisting of ethyl eosin, eosin Y, rose bengal, camphorquinone and erythrosin; and thermally activatable molecules selected from the group consisting of 4,4' azobis(4-cyanopentanoic) acid, and 2,2-azobis(2-(2-imidazolin-2-yl) propane) dihydrochloride, and benzoyl peroxide; and the pendent polymerizable groups are selected from the group consisting of acrylate groups, methacrylate groups, ethacrylate groups, 2-phenyl acrylate groups, acrylamide groups, methacrylamide groups, itaconate groups, and styrene groups.
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