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Uses of Wnt polypeptides 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-045/05
  • C12N-005/02
  • A01N-037/18
  • C07K-001/00
출원번호 US-0911860 (1997-08-15)
발명자 / 주소
  • Matthews William
  • Austin Timothy W.
출원인 / 주소
  • Genentech, Inc.
대리인 / 주소
    Svoboda
인용정보 피인용 횟수 : 22  인용 특허 : 33

초록

Uses for Wnt polypeptides in hematopoiesis are disclosed. In particular, in vitro and in vivo methods for enhancing proliferation, differentiation or maintenance of a hematopoietic stem/progenitor cell using a Wnt polypeptide, and optionally another cytokine, are described.

대표청구항

[ What is claimed is:] [1.] A method for enhancing or increasing myelopoiesis, erythropoiesis or lymphopoiesis comprising exposing hematopoietic stem/progenitor cells to an amount of isolated Wnt polypeptide effective for stimulating proliferation or differentiation of the cells.

이 특허에 인용된 특허 (33)

  1. Ayers John S. (Palmerston North NZX) Bethell Geoffrey S. (Palmerston North NZX) Hancock William S. (Palmerston North NZX) Hearn Milton T. W. (Dunedin North NZX), Activated matrix and method of activation.
    상세보기
  2. Iwashita Yuji (Kawasaki JPX) Ajisaka Katsumi (Yokohama JPX), Blood substitute containing modified hemoglobin.
    상세보기
  3. Jaworek Dieter (Weilheim ; Upper Bavaria DT) Nelbock-Hochstetter Michael (Tutzing DT) Beaucamp Klaus (Tutzing DT) Bergmeyer Hans Ulrich (Tutzing DT) Botsch Karl-Heinz (Bernried DT), Carrier-bound protein prepared by reacting the protein with an acylating or alkylating compound having a carrier-bonding.
    상세보기
  4. Darfler Frederick J. (Derwood MD), Cell culture medium with antioxidant.
    상세보기
  5. Nakagawa Yasushi (Kawanishi JPX) Ito Takashi (Osaka JPX), Chemically modified protein with polyethyleneglycol.
    상세보기
  6. Mitra Gautam (Kensington CA), Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer.
    상세보기
  7. Brake Anthony J. (Berkeley CA) Van Den Berg Johan A. (Ad Reeuwijk NLX), DNA constructs containing a Kluyveromyces alpha factor leader sequence for directing secretion of heterologous polypepti.
    상세보기
  8. Hirohara Hideo (Ibaraki JPX) Nabeshima Shigeyasu (Ibaraki JPX) Fujimoto Masanori (Ibaraki JPX) Nagase Tsuneyuki (Takatsuki JPX), Enzyme immobilization with pullulan gel.
    상세보기
  9. Iwasaki Keiji (Kawasaki JPX) Iwashita Yuji (Kawasaki JPX) Okami Taketoshi (Yokohama JPX), Hemoglobin combined with a poly(alkylene oxide).
    상세보기
  10. David Gary S. (La Jolla CA) Greene Howard E. (Carlsbad CA), Immunometric assays using monoclonal antibodies.
    상세보기
  11. Van den Berg Johan A. (Ad Reeuwijk NLX) Van Ooyen Albert J. J. (AR Voorburg NLX) Rietveld Krijn (TL Vlaardingen NLX), Kluyveromyces as a host strain.
    상세보기
  12. Ryan, Patrick J.; Davis, Michael A.; Melchior, Donald L., Liposomes containing modified cholesterol for organ targeting.
    상세보기
  13. Woodle Martin C. (Menlo Park CA) Martin Francis J. (San Francisco CA) Yau-Young Annie (Los Altos CA) Redemann Carl T. (Walnut Creek CA), Liposomes with enhanced circulation time.
    상세보기
  14. Litman David J. (Palo Alto CA) Harel Zvi (Stanford CA) Ullman Edwin F. (Atherton CA), Macromolecular environment control in specific receptor assays.
    상세보기
  15. Karin Michael (Los Angeles CA), Mammalian metallothionein promoter system.
    상세보기
  16. Mather Jennie P. (Millbrae CA) Tsao Mary C. (Burlingame CA), Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins.
    상세보기
  17. Matthews William ; Austin Timothy W., Method of enhancing proliferation or differentiation of hematopoietic stem cells using Wnt polypeptides.
    상세보기
  18. Royer Garfield P. (Worthington OH), Modifying enzymes with polyethylene glycol and product produced thereby.
    상세보기
  19. Davis Frank F. (19 Farmingdale Rd. East Brunswick NJ 08816) Van Es Theodorus (313 Overbrook Rd. Piscataway NJ 08854) Palczuk Nicholas C. (45 W. Franklin St. Bound Brook NJ 08805), Non-immunogenic polypeptides.
    상세보기
  20. Beckwith Jonathan R. (Cambridge MA) Strauch Kathryn L. (Brighton MA), Periplasmic protease mutants of Escherichia coli.
    상세보기
  21. Drayna Dennis T. (San Francisco CA) Eaton Dan L. (San Rafael CA), Plasma carboxypeptidase.
    상세보기
  22. Shimizu Kimihiro (Yoshikawa JPX) Nakahara Tsuguji (Tokyo JPX) Kinoshita Taketoshi (Koshigaya JPX) Takatsuka Jun (Kawasaki JPX) Igarashi Michiko (Musashino JPX), Plasminogen activator derivatives.
    상세보기
  23. Hildebrand Dietrich (Odenthal DEX) Gribnau Thomas (Weezenhof NLX), Polymeric carrier bound ligands.
    상세보기
  24. Capon Daniel J. (San Mateo CA) Lawn Richard M. (San Francisco CA) Levinson Arthur D. (Hillsborough CA) Vehar Gordon A. (San Carlos CA) Wood William I. (San Mateo CA), Preparation of functional human factor VIII in mammalian cells using methotrexate based selection.
    상세보기
  25. Hodgins Leonard T. (New York NY) Finlay Thomas H. (Ridgewood NJ) Johnson Alan J. (New York NY), Preparation of trichloro-s-triazine activated supports for coupling ligands.
    상세보기
  26. Axel Richard (New York NY) Wigler Michael H. (Cold Spring Harbor NY) Silverstein Saul J. (Irvington NY), Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials.
    상세보기
  27. Cleveland William L. (New York NY) Erlanger Bernard F. (Whitestone NY), Protein-free culture medium.
    상세보기
  28. Howley Peter M. (Bethesda MD) Sarver Nava (Bethesda MD) Law Ming-Fan (Germantown MD), Recombinant DNA process utilizing a papilloma virus DNA as a vector.
    상세보기
  29. Cabilly Shmuel (Monrovia CA) Heyneker Herbert L. (Burlingame CA) Holmes William E. (Pacifica CA) Riggs Arthur D. (La Verne CA) Wetzel Ronald B. (San Francisco CA), Recombinant immunoglobin preparations.
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  30. Cartaya Oscar A. (125 Pleasant St. ; Apt. #401 Brookline MA 02146), Serum-free cell culture media.
    상세보기
  31. Baker, Paul E., Serum-free cell culture medium and process for making same.
    상세보기
  32. Kumar Sudhir (18901 Springfield Flossmoor IL 60422), Serum-free, synthetic, completely chemically defined tissue culture media.
    상세보기
  33. Segal David M. (Rockville MD) Perez Pilar (Bethesda MD), Target specific cross-linked heteroantibodies.
    상세보기

이 특허를 인용한 특허 (22)

  1. Nusse, Roeland; Willert, Karl H., Compositions of active WNT protein.
    상세보기
  2. Nusse, Roeland; Willert, Karl H., Compositions of active Wnt protein.
    상세보기
  3. Nusse, Roeland; Willert, Karl H., Compositions of active Wnt protein.
    상세보기
  4. Nusse, Roeland; Willert, Karl H., Compositions of active Wnt protein.
    상세보기
  5. Nusse, Roeland; Willert, Karl H., Compositions of active Wnt protein.
    상세보기
  6. Nusse,Roeland; Willert,Karl H., Compositions of active Wnt protein.
    상세보기
  7. Nusse,Roeland; Willert,Karl H., Compositions of active Wnt protein.
    상세보기
  8. Lang, Richard, Compositions useful for and methods of modulating angiogenesis.
    상세보기
  9. Jones, Stephen N.; Liang, Huiling; Pihan, German, Diagnosing and treating hematopoietic cancers.
    상세보기
  10. Rudnicki, Michael; Seale, Patrick; Polesskaya, Anna; Fortin, Anouk, Growth and differentiation of adult muscle stem cells with activators or inhibitors of Wnt signaling.
    상세보기
  11. Zonana,Jonathan; Ferguson,Betsy M.; Headon,Denis; Overbeek,Paul, Hypohidrotic ectodermal dysplasia genes and proteins.
    상세보기
  12. Basile, Lena A., IL-12 formulations for enhancing hematopoiesis.
    상세보기
  13. Chen, Tingchao; Zhao, Yi; Anderson, W. French, Method for bone marrow preservation or recovery.
    상세보기
  14. Sulkowski, Eugene; Chadha, Kailash C.; Kawinski, Elzbieta, Method for detecting PSA and its molecular forms using thiophilic gel on magnetic beads.
    상세보기
  15. Chen, Tingchao; Zhao, Yi; Anderson, W. French, Method for treating deficiency in hematopoiesis.
    상세보기
  16. Perry, John M.; Li, Linheng; Grindley, Justin C., Methods and compositions for stem cell self-renewal.
    상세보기
  17. Perry, John M.; Li, Linheng; Grindley, Justin C., Methods and compositions for stem cell self-renewal.
    상세보기
  18. Salas, Joe; Peters, Robert, Processable single chain molecules and polypeptides made using same.
    상세보기
  19. Chen, Tingchao; Zhao, Yi; Anderson, W. French, Uses of IL-12 in hematopoiesis.
    상세보기
  20. Chen, Tingchao; Zhao, Yi; Anderson, W. French, Uses of IL-12 in hematopoiesis.
    상세보기
  21. Chen, Tingchao; Zhao, Yi; Anderson, W. French, Uses of IL-12 in hematopoiesis.
    상세보기
  22. Li, Yonggang, Utilizing aperture with phase shift feature in forming microvias.
    상세보기

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