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Up-converting reporters for biological and other assays 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C12Q-001/68
  • C07H-021/02
  • C07H-021/04
  • C07K-016/00
  • G01N-033/53
  • H05B-033/00
출원번호 US-0016402 (1998-01-30)
발명자 / 주소
  • Kardos Keith W.
  • Niedbala R. Sam
  • Burton Jarrett Lee
  • Cooper David E.
  • Zarling David A.
  • Rossi Michel J.,CHX
  • Peppers Norman A.
  • Kane James
  • Faris Gregory W.
  • Dyer Mark J.
  • Ng Steve Y.
  • Sc
출원인 / 주소
  • SRI International
대리인 / 주소
    Morgan, Lewis & Bockius LLP
인용정보 피인용 횟수 : 76  인용 특허 : 39

초록 ▼

The invention provides methods, compositions, and apparatus for performing sensitive detection of analytes, such as biological macromolecules and other analytes, by labeling a probe molecule with an up-converting label. The up-converting label absorbs radiation from an illumination source and emits

대표청구항 ▼

[ The claimed invention is:] [1.] A composition for detecting an analyte in a sample using matched labels, comprising:a pair of matched up-converting and luminescent labeled probes, wherein the up-converting labeled probe is an inorganic phosphor particle comprising at least one rare earth element a

이 특허에 인용된 특허 (39)

  1. Stavrianopoulos Jannis (New York NY) Rabbani Elazar (New York NY) Abrams Samuel B. (New York NY) Wetmur James G. (Scardsdale NY), Analyte detection by means of energy transfer.
    상세보기
  2. Buican Tudor N. (Albuquerque NM), Apparatus and method for measuring fluorescence intensities at a plurality of wavelengths and lifetimes.
    상세보기
  3. Tomioka Atsuo (Chatsworth CA) Harada Hiroyuki (Hyogo JPX) Inami Keiichi (Hyogo JPX), Apparatus for measuring lymphocyte subclasses.
    상세보기
  4. Cohen Saul G. (Boston MA) Inbar Shai (Boston MA), Biological diagnostic assay system.
    상세보기
  5. Kosak Kenneth M. (3194 S. 4400 West Salt Lake City UT 84120), Bioluminescent tracer composition and method of use in immunoassays.
    상세보기
  6. Mandle Richard M. (Pompton Lakes NJ) Wong Yuan N. (Boonton NJ), Chemical luminescence amplification substrate system for immunochemistry involving microencapsulated fluorescer.
    상세보기
  7. Rajagopalan Raghavan (Maryland Heights MO) Wallace Rebecca A. (Manchester MO) Periasamy Muthunadar P. (Creve Coeur MO), Complexes and compositions for magnetic resonance imaging and usage methods.
    상세보기
  8. Chupp Vernon L. (Los Alto CA), Dual laser excitation from single laser source.
    상세보기
  9. Ogino Shinichi (Hyogo JPX), Flow imaging cytometer.
    상세보기
  10. Chan Joseph L. W. (Quincy MA), Fluorescent energy transfer with phycobiliproteins.
    상세보기
  11. Singer Victoria L. (Eugene OR) Haugland Richard P. (Eugene OR), Fluorescent labeling using microparticles with controllable stokes shift.
    상세보기
  12. Brinkley John M. (Elmira OR) Haugland Richard P. (Eugene OR) Singer Victoria L. (Eugene OR), Fluorescent microparticles with controllable enhanced stokes shift.
    상세보기
  13. Cheung Sau W. (8528 Douglas Ct. St. Louis MO 63144), Fluorescent microspheres and methods of using them.
    상세보기
  14. Berndt Klaus W. (Baltimore) Gryczynski Ignacy (Baltimore) Lakowicz Joseph R. (Columbia MD), Fluorometry method and apparatus using a semiconductor laser diode as a light source.
    상세보기
  15. Boguslaski Robert C. (Elkhart IN) Carrico Robert J. (Bremen IN) Christner James E. (Ann Arbor MI), Heterogenous specific binding assay employing an enzyme substrate as label.
    상세보기
  16. Kosak Kenneth (3194 S. 4400 West Salt Lake City UT 84120), Immunoscintillation cell.
    상세보기
  17. Tanke Hendrikus J. (Rijnsburg NLX) Slats Johannes C. (Noordwikjerhout NLX) Ploem Johan S. (Oegstgeest NLX), Inorganic phosphor labelled macromolecules; a process for their preparation and their use for immunological or immunocyt.
    상세보기
  18. Sievers Robert E. (Fairborn OH), Lanthanide chelate of a fluorinated ligand.
    상세보기
  19. Chagnon Mark S. (Lowell MA) Groman Ernest V. (Brookline MA) Josephson Lee (Arlington MA) Whitehead Roy A. (Hingham MA), Magnetic particles for use in separations.
    상세보기
  20. Fodor Stephen P. A. (Palo Alto CA) Mazzola Laura T. (Redwood City CA), Method and apparatus for measuring binding affinity.
    상세보기
  21. Buican Tudor N. (Los Alamos NM) Martin John C. (Los Alamos NM), Method and apparatus for simultaneously measuring a plurality of spectral wavelengths present in electromagnetic radiati.
    상세보기
  22. Recktenwald Diether J. (Cupertino CA), Method for analysis of subpopulations of blood cells.
    상세보기
  23. Reddington John J. (Wilton CT) Reddington Ginger M. (Wilton CT), Method for determining bluetongue virus antibodies in serum.
    상세보기
  24. Mathis Grard (Bagnols-sur-Ceze FRX) Dumont Christophe (Connaux FRX) Aspe Daniel (Laudun FRX) Foyentin Muriel (Avignon FRX) Jolu Etienne J. (Bagnols-sur-Ceze FRX) Nuti Dominique (Avignon FRX), Method of amplifying the emission signal of a luminescent compound.
    상세보기
  25. Hevey Richard C. (Rockport ME) Malmros Mark K. (Newton PA), Methods for the detection and determination of ligands.
    상세보기
  26. Singh Sharat (San Jose CA) Singh Rajendra (Mountain View CA) Meneghini Frank (Keene NH) Ullman Edwin F. (Atherton CA), Methods of use for and kits containing chemiluminescent compounds.
    상세보기
  27. Hemmila Ilkka (Turku FIX) Lovgren Timo (Turku FIX), Modulated homogeneous fluorescence biospecific affinity assay employing fluorescing lanthanide chelates as covalent labe.
    상세보기
  28. Gavrilovic Pavle (Brockton MA) Singh Shobha (Summit NJ), Optically pumped up converting light source.
    상세보기
  29. Imai Kazumichi (Kodaira JPX) Tokinaga Daizo (Hachioji JPX) Yokosawa Koichi (Kokubunji JPX), Particle agglutination immunoassay apparatus.
    상세보기
  30. Toner John L. (Webster NY), Polypyridine Fluorescent labels for immunoassay.
    상세보기
  31. Steen Harald B. (Oslo NOX) Sorensen Otto (Oslo NOX), Pulse modulation of the excitation light source of flow cytometers.
    상세보기
  32. Auzel Francois F. (39 Avenue Port Royal des Champs 78320 Le Mesnil St. Denis FR) Morin Denise M. (44 ; rue de Goulmiers 94130 Nogent-Sur-Marne FR) Pecile Dario C. (17 ; Boulevard Andre 93250 Villemom, Rare earth ceramic for frequency conversion of radiation.
    상세보기
  33. Hirschfeld ; Tomas R., Serum fluorescence suppression.
    상세보기
  34. Paz-Pujalt Gustavo R. (Rochester NY) Moon Charles R. (Rochester NY), Test element for optically testing biological fluids in clinical diagnostic applications.
    상세보기
  35. Miller Steven M. (Chelmsford MA), Ultratrace analysis of transuranic actinides by laser-induced fluorescence.
    상세보기
  36. Zarling David A. (Menlo Park CA) Rossi Michel J. (Lausanne CHX) Peppers Norman A. (Belmont CA) Kane James (Lawrenceville NJ) Faris Gregory W. (Menlo Park CA) Dyer Mark J. (San Jose CA) Ng Steve Y. (S, Up-converting reporters for biological and other assays using laser excitation techniques.
    상세보기
  37. Zarling David A. (Menlo Park CA) Rossi Michel J. (Lausanne CHX) Peppers Norman A. (Belmont CA) Kane James (Lawrenceville NJ) Faris Gregory W. (Menlo Park CA) Dyer Mark J. (San Jose CA) Ng Steve Y. (S, Up-converting reporters for biological and other assays using laser excitation techniques.
    상세보기
  38. Zarling David A. ; Rossi Michel J.,CHX ; Peppers Norman A. ; Kane James ; Faris Gregory W. ; Dyer Mark J. ; Ng Steve Y. ; Schneider Luke V., Up-converting reporters for biological and other assays using laser excitation techniques.
    상세보기
  39. Lee Linda (Mountain View CA), Xanthene dyes that emit to the red of fluorescein.
    상세보기

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  4. McNaughton, Brandon H.; Kinnunen, Paivo; Kopelman, Raoul; Hunt, Alan; Clarke, Roy; Sinn, Irene; Elbez, Remy; Albertson, Theodore, Asynchronous magnetic bead rotation sensing systems and methods.
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  5. Ortyn, William E.; Basiji, David A.; Morrissey, Philip J.; George, Thaddeus C.; Hall, Brian E.; Zimmerman, Cathleen A.; Perry, David J., Blood and cell analysis using an imaging flow cytometer.
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  6. Ortyn, William; Basiji, David; Morrissey, Philip; George, Thaddeus; Hall, Brian; Zimmerman, Cathleen; Perry, David, Blood and cell analysis using an imaging flow cytometer.
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  7. Loveridge,Dan, Dental compositions having anti-stokes up converters and methods of use.
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  8. Dejneka,Matthew J.; Lahiri,Joydeep; Muller,Uwe R.; Tanner,Cameron W.; Tepesch,Patrick D., Detectable labels, methods of manufacture and use.
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  9. Basiji, David A.; Ortyn, William E.; Morrissey, Philip J.; Venkatachalam, Vidya, Detection of circulating tumor cells using imaging flow cytometry.
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  12. Hofstraat, Johannes Willem, Diagnostic neodymium(III), ytterbium(III), or erbium(III) ion-ligand complexes.
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  13. Zuppero,Anthony C.; Gidwani,Jawahar M., Diode energy converter for chemical kinetic electron energy transfer.
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  15. Zuppero, Anthony C.; Gidwani, Jawahar M., Electron-jump chemical energy converter.
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  17. Rolfe C. Anderson, Electronic detection of hybridization on nucleic acid arrays.
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  18. Ortyn, William; Basiji, David; Frost, Keith; Liang, Luchuan; Bauer, Richard; Hall, Brian; Perry, David, Extended depth of field imaging for high speed object analysis.
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  20. Hartley, Frank T., Field ionizing elements and applications thereof.
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  27. Zoromski, Michele L.; Atanasoska, Liliana L.; Warner, Robert W., Functionalized block copolymers.
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  28. Zuppero,Anthony C.; Gidwani,Jawahar M., Gas specie electron-jump chemical energy converter.
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  29. Kmiec,Eric B.; Gamper,Howard B.; Rice,Michael C.; Usher,Michael G., Genomics applications for modified OLIGO nucleotides.
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  38. Regelman, Dan Vadim, Method and system for optical measurements of contained liquids having a free surface.
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