초록 ▼

Methods and apparatus of forming in situ tissue adherent barriers are provided using a sprayer capable of applying two or more viscous crosslinkable solutions to tissue. The sprayer comprises separate spray nozzles for each of two or more crosslinkable solutions, wherein each nozzle is either surrou

Methods and apparatus of forming in situ tissue adherent barriers are provided using a sprayer capable of applying two or more viscous crosslinkable solutions to tissue. The sprayer comprises separate spray nozzles for each of two or more crosslinkable solutions, wherein each nozzle is either surrounded by an annular gas flow outlet or in communication with a gas-pressurized chamber, and also may include valves that prevent backflow through the supply lines carrying the crosslinkable solutions, and a venting system for venting excess pressure for laparoscopic applications In the presence of gas flow, the crosslinkable solutions are atomized and mixed to form a spray. Multi-component hydrogel systems suitable for use with the inventive methods and apparatus are also described.

대표청구항 ▼

[ What is claimed is:] [1.] Apparatus for forming in situ, in a tissue cavity, a tissue adherent coating from at least first and second solutions, the apparatus comprising:first and second chambers for storing the first and second solutions;a third chamber coupled to a source of pressurized gas;a fi

[ What is claimed is:] [1.] Apparatus for forming in situ, in a tissue cavity, a tissue adherent coating from at least first and second solutions, the apparatus comprising:first and second chambers for storing the first and second solutions;a third chamber coupled to a source of pressurized gas;a first nozzle coupled to a first supply line, the first supply line being in fluid. communication with the first chamber and having an opening in communication with the third chamber; anda second nozzle coupled to a second supply line, the second supply line being in fluid communication with the second chamber and having an opening in communication with the third chamber,wherein pressurized gas entering the third chamber enters the first and second supply lines and propels the first and second solutions out of the first and second nozzles, respectively, to atomize and mixes the first solution with the second solution.