초록 ▼

Blends of biodegradable polymers, preferably poly(caprolactone) and poly(D,L-lactic-co-glycolic) acid are discussed as well as their applications in the medical field, particularly with regard to bone tissue engineering. Preferably, hydroxyapatite ("HA") granules are incorporated into the blends and

Blends of biodegradable polymers, preferably poly(caprolactone) and poly(D,L-lactic-co-glycolic) acid are discussed as well as their applications in the medical field, particularly with regard to bone tissue engineering. Preferably, hydroxyapatite ("HA") granules are incorporated into the blends and the resulting blends have desirable mechanical, physical, and biological characteristics. Even more preferably the compositions of the present invention are utilized to form osteoconductive composites that supported bone cell growth on the surface as well as throughout the scaffold.

대표청구항 ▼

[ What is claimed is:] [1.] A composition comprised of:a bioceramic material;a polycaprolactone; anda copolymer of poly(lactic) acid and poly(glycolic) acid;said copolymer and said polycaprolactone blended at a predetermined ratio, said predetermined ratio being in the range of from about 10:90 poly

[ What is claimed is:] [1.] A composition comprised of:a bioceramic material;a polycaprolactone; anda copolymer of poly(lactic) acid and poly(glycolic) acid;said copolymer and said polycaprolactone blended at a predetermined ratio, said predetermined ratio being in the range of from about 10:90 polycaprolactone to copolymer to about 50:50 polycaprolactone to copolymer. [5.] A method of treating a patient for a boney defect comprising the steps of:mixing a polycaprolactone and a copolymer of poly(lactic) acid and poly(glycolic)acid to form a blend having a ratio of polycaprolactone:copolymer in the range of about 10:90 to about 50:50;adding a bioceramic material to said blend;molding said blend and said bioceramic into an implant; andimplanting said implant into said patient. [10.] A method of treating a patient for a cranio-facial defect comprising the steps of:mixing a polycaprolactone and a copolymer of poly(lactic) acid and poly(glycolic)acid to form a blend having a ratio of polycaprolactone:copolymer in the range of about 10:90 to about 50:50;adding a bioceramic material to said blend;molding said blend and said bioceramic into an implant; andimplanting said implant into said patient. [11.] A method of treating a patient in need of a bone substitute comprising the steps of:mixing a polycaprolactone and a copolymer of poly(lactic) acid and poly(glycolic)acid to form a blend having a ratio of polycaprolactone:copolymer in the range of about 10:90 to about 50:50;adding a bioceramic material to said blend;molding said blend and said bioceramic into an implant; andimplanting said implant into said patient. The method of claim 5, wherein said implant is a prosthetic template. The method of claim 5, wherein said implant is a template for bone formation. The method of claim 5, wherein said copolymer is at a ratio of about 65:35 lactic acid:glycolic acid. The method of claim 10, wherein said copolymer is at a ratio of about 65:35 lactic acid:glycolic acid. The method of claim 11, wherein said copolymer is at a ratio of about 65:35 lactic acid:glycolic acid.