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Therapeutic preparation for inhalation 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-038/28
  • C07K-014/62
출원번호 US-0072717 (1998-05-05)
발명자 / 주소
  • Backstrom Kjell Goran Erik,SEX
  • Dahlback Carl Magnus Olof,SEX
  • Edman Peter,SEX
  • Johansson Ann Charlotte Birgit,SEX
출원인 / 주소
  • Astra Aktiebolag, SEX
대리인 / 주소
    Fish & Richardson P.C.
인용정보 피인용 횟수 : 39  인용 특허 : 31

초록

A therapeutic preparation for inhalation which comprises insulin and a substance which enhances the absorption of insulin in the lower respiratory tract, is provided in the form of a powder preparation suitable for inhalation.

대표청구항 ▼

[ What is claimed is:] [1.] A therapeutic preparation comprising active compounds (A) insulin and (B) a substance which enhances the absorption of insulin in the lower respiratory tract, in the form of a dry powder suitable for inhalation in which at least 50% of the total mass of active compounds c

이 특허에 인용된 특허 (31)

  1. Meezan Elias (Birmingham AL) Pillion Dennis J. (Birmingham AL), Absorption enhancers for drug administration.
    상세보기
  2. Alexander Jose (Lawrence KS) Repta A. J. (Lawrence KS) Fix Joseph A. (Lawrence KS), Acylcarnitines as absorption-enhancing agents for drug delivery through mucous membranes of the nasal, buccal, sublingua.
    상세보기
  3. Wetterlin Kjell I. L. (S Sandby SEX) Virtanen Risto (Nurmijrvi FIX) Andersson Jan A. R. (S Sandby SEX), Device in powder inhalators.
    상세보기
  4. Platz Robert M. ; Brewer Thomas K. ; Boardman Terence D., Dispersible macromolecule compositions and methods for their preparation and use.
    상세보기
  5. Wetterlin Kjell I. L. (S Sandby SEX), Dosage inhalator.
    상세보기
  6. Wetterlin Kjell I. L. (S Sandby SEX), Dosage inhalator.
    상세보기
  7. Carey Martin C. (Wellesley MA) Moses Alan C. (Waban MA) Flier Jeffrey S. (West Newton MA), Drug administration.
    상세보기
  8. Carey Martin C. (Wellesley MA) Moses Alan C. (Waban MA) Flier Jeffrey S. (West Newton MA), Drug administration.
    상세보기
  9. Carey, Martin C.; Moses, Alan C.; Flier, Jeffrey S., Drug administration.
    상세보기
  10. Alexander, Jose; Fix, Joseph A., Enhancing absorption of drugs from gastrointestinal tract using acylcarnitines.
    상세보기
  11. Virtanen Risto (Nurmijrvi FIX), Indicating means for a dosage dispensing device.
    상세보기
  12. Rubsamen Reid M. (Berkeley CA), Intrapulmonary delivery of hormones.
    상세보기
  13. Clark Andrew R. (Loughborough GB2) Hart John L. (Bramcote GB2), Medicament inhalation device and formulation.
    상세보기
  14. Hora Maninder Singh ; Rubinfeld Joseph ; Stern Warren ; Wong Gregory J., Method and compositions for solubilization and stabilization of polypeptides, especially proteins.
    상세보기
  15. Laube, Beth L.; Adams, III, G. Kenneth; Georgopoulos, Angeliki, Method of administering insulin.
    상세보기
  16. Rubsamen Reid M. (Berkeley CA), Method of administration of insulin.
    상세보기
  17. Patton John S. ; Foster Linda ; Platz Robert M., Methods and compositions for pulmonary delivery of insulin.
    상세보기
  18. Hansen Philip E. (Copenhagen DKX) Sorensen Anders R. (Herlev DKX), Nasal formulation and intranasal administration therewith.
    상세보기
  19. Buck Stephen H. ; Harbeson Scott L. ; Krstenansky John L. ; Hassman ; III Chester F. ; McCarthy James R., Neurokinin A antagonists.
    상세보기
  20. Kagatani Seiya (Shizuoka JPX) Hasumi Shunji (Shizuoka JPX) Sonobe Takashi (Shizuoka JPX) Aruga Masayoshi (Shizuoka JPX), Pharmaceutical compositions comprising calcitonin and an absorption-promoting substance.
    상세보기
  21. Kagatani Seiya (Shizuoka JPX) Hasumi Shunji (Shizuoka JPX) Sonobe Takashi (Shizuoka JPX) Aruga Masayoshi (Shizuoka JPX), Pharmaceutical compositions for nasal administration comprising calcitonin and an absorption-promoting substance.
    상세보기
  22. Suzuki Yoshiki (Tokyo JPX) Sekine Kunio (Tokyo JPX) Nagai Tsuneji (Tokyo JPX) Nambu Naoki (Kanagawa JPX) Nishimoto Yuji (Tokyo JPX), Powdery pharmaceutical composition for nasal administration.
    상세보기
  23. Miyauchi Yasuyo (Yokohama JPX), Preparation which promotes the absorption of peptides.
    상세보기
  24. Samejima Masayoshi (Mino) Noda Kazuo (Takarazuka) Kobayashi Masao (Kyoto) Osawa Takashi (Toyonaka JPX), Process for micronizing slightly-soluble drug.
    상세보기
  25. Platz Robert M. (Half Moon Bay CA) Ip Anna (Moorpark CA) Whitham Clyde L. (Montara CA), Process for preparing micronized polypeptide drugs.
    상세보기
  26. Platz Robert M. (Half Moon Bay CA) Winters Mark A. (Mountain View CA) Pitt Colin G. (Thousand Oaks CA), Pulmonary administration of granulocyte colony stimulating factor.
    상세보기
  27. Benson Bradley J. (170 Cresta Vista Dr. San Francisco CA 94127) Wright JoRae (170 Cresta Vista Dr. San Francisco CA 94127), Pulmonary administration of pharmaceutically active substances.
    상세보기
  28. Patton John S., Pulmonary delivery of active fragments of parathyroid hormone.
    상세보기
  29. Patton John S. (San Carlos CA), Pulmonary delivery of active fragments of parathyroid hormone.
    상세보기
  30. Wong Jeffrey T.-F. (Hong Kong HKX) Tam Michael S.-C. (Shatin HKX), Pulmonary drug delivery system.
    상세보기
  31. Illum Lisbeth,GB2, Small particle compositions for intranasal drug delivery.
    상세보기

이 특허를 인용한 특허 (39)

  1. B?ckstr?m, Kjell; Dahlb?ck, Magnus; Johansson, Ann; K?llstrand, G?ran; Lindqvist, Elisabet, Aerosol drug formulations containing hydrofluoroalkanes and alkyl saccharides.
    상세보기
  2. Backstrom, Kjell; Dahlback, Magnus; Johansson, Ann; Kallstrand, Goran; Lindqvist, Elisabet, Aerosol formulations of peptides and proteins.
    상세보기
  3. Ekwuribe, Nnochiri N.; Radhakrishnan, Balasingam, Calcitonin drug-oligomer conjugates, and uses thereof.
    상세보기
  4. Ekwuribe, Nnochiri N.; Radhakrishnan, Balasingam, Calcitonin drug-oligomer conjugates, and uses thereof.
    상세보기
  5. Radhakrishnan, Balasingam; Aggarwal, Diti; Ferro, Michelle; James, Kenneth D.; Malkar, Navdeep B.; Miller, Mark A.; Puskas, Monica; Ekwuribe, Nnochiri N., Cation complexes of insulin compound conjugates, formulation and uses thereof.
    상세보기
  6. Radhakrishnan, Balasingam; Aggarwal, Diti; Ferro, Michelle; James, Kenneth D.; Malkar, Navdeep B.; Miller, Mark A.; Puskas, Monica; Ekwuribe, Nnochiri N., Cation complexes of insulin compound conjugates, formulations and uses thereof.
    상세보기
  7. Bäckström, Kjell Göran Erik; Dahlbäck, Carl Magnus Olof; Edman, Peter; Johansson, Ann Charlotte Birgit, Compositions for inhalation.
    상세보기
  8. Backstrom, Kjell Goran Erik; Dahlback, Carl Magnus Olof; Edman, Peter; Johansson, Ann Charlotte Birgit, Compositions for inhalation.
    상세보기
  9. Ekwuribe,Nnochiri N.; Ramaswamy,Muthukumar; Rajagopalan,Jayanthi, Drug-oligomer conjugates with polyethylene glycol components.
    상세보기
  10. Radhakrishnan, Balasingam; Aggarwal, Diti; Ferro, Michelle; James, Kenneth D.; Malkar, Navdeep B.; Miller, Mark A.; Pavliv, Leo; Polowy, Karen; Puskas, Monica; Ekwuribe, Nnochiri N., Fatty acid formulations and oral delivery of proteins and peptides, and uses thereof.
    상세보기
  11. Radhakrishnan, Balasingam; Aggarwal, Diti; Ferro, Michelle; James, Kenneth D.; Malkar, Navdeep B.; Miller, Mark A.; Pavliv, Leo; Polowy, Karen; Puskas, Monica; Ekwuribe, Nnochiri N., Fatty acid formulations for oral delivery of proteins and peptides, and uses thereof.
    상세보기
  12. Ekwuribe,Nnochiri N.; Price,Christopher H.; Still,James Gordon; Filbey,Jennifer Ann; Ansari,Aslam M.; Odenbaugh,Amy L.; Radhakrishnan,Balasingam, Insulin conjugates for treating diabetes mellitus.
    상세보기
  13. Radhakrishnan,Balasingam; Soltero,Richard; Ekwuribe,Nnochiri N.; Puskas,Monica; Sangal,Diti, Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same.
    상세보기
  14. Soltero,Richard; Radhakrishnan,Balasingam; Ekwuribe,Nnochiri N., Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same.
    상세보기
  15. Ekwuribe,Nnochiri N.; Ramaswamy,Muthukumar; Rajagopalan,Jayanthi, Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin.
    상세보기
  16. Radhakrishnan, Balasingam; Aggarwal, Diti; Ferro, Michelle; James, Kenneth D.; Malkar, Navdeep B.; Miller, Mark A.; Puskas, Monica E.; Ekwuribe, Nnochiri N., Insulin-oligomer conjugates, formulations and uses thereof.
    상세보기
  17. Radhakrishnan, Balasingam; Aggarwal, Diti; Ferro, Michelle; James, Kenneth D.; Malkar, Navdeep B.; Miller, Mark A.; Puskas, Monica; Ekwuribe, Nnochiri N., Insulin-oligomer conjugates, formulations and uses thereof.
    상세보기
  18. Chickering, III, Donald E.; Narasimhan, Sridhar; Altreuter, David; Kopesky, Paul; Keegan, Mark; Straub, Julie A.; Bernstein, Howard, Methods and apparatus for making particles using spray dryer and in-line jet mill.
    상세보기
  19. Chickering, III, Donald E.; Narasimhan, Sridhar; Altreuter, David; Kopesky, Paul; Keegan, Mark; Straub, Julie A.; Bernstein, Howard, Methods and apparatus for making particles using spray dryer and in-line jet mill.
    상세보기
  20. Chickering, III, Donald E.; Narasimhan, Sridhar; Altreuter, David; Kopesky, Paul; Keegan, Mark; Straub, Julie A.; Bernstein, Howard, Methods and apparatus for making particles using spray dryer and in-line jet mill.
    상세보기
  21. Still, James Gordon; Kosutic, Gordana, Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus.
    상세보기
  22. Soltero, Richard; Radhakrishnan, Balasingam; Ekwuribe, Nnochiri N., Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same.
    상세보기
  23. Ekwuribe, Nnochiri N.; Price, Christopher H.; Ansari, Aslam M.; Odenbaugh, Amy L., Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties.
    상세보기
  24. Ekwuribe,Nnochiri N.; Price,Christopher H.; Still,James Gordon; Filbey,Jennifer Ann, Methods of treating diabetes mellitus.
    상세보기
  25. Ekwuribe, Nnochiri N.; Price, Christopher H.; Ansari, Aslam M.; Odenbaugh, Amy L., Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same.
    상세보기
  26. Ekwuribe,Nnochiri N.; Price,Christopher H.; Ansari,Aslam M.; Odenbaugh,Amy L., Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same.
    상세보기
  27. Ekwuribe, Nnochiri N.; Price, Christopher H.; Ansari, Aslam M.; Odenbaugh, Amy L., Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same.
    상세보기
  28. Ekwuribe, Nnochiri N.; Price, Christopher H.; Ansari, Aslam M.; Odenbaugh, Amy L., Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same.
    상세보기
  29. Ekwuribe,Nnochiri N.; Price,Christopher H.; Ansari,Aslam M.; Radhakrishnan,Balasingam; Odenbaugh,Amy L., Mixtures of insulin drug-oligomer comprising polyalkylene glycol.
    상세보기
  30. Ekwuribe, Nnochiri N.; Price, Christopher H.; Ansari, Aslam M.; Radhakrishnan, Balasingam; Odenbaugh, Amy L., Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same.
    상세보기
  31. Ekwuribe,Nnochiri N.; Price,Christopher H.; Ansari,Aslam M.; Radhakrishnan,Balasingam; Odenbaugh,Amy L., Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same.
    상세보기
  32. Khedkar, Anand; Rangappa, Sharath Kumar Mallapura; Subramani, Ramesh; Dave, Nitesh; Radhakrishnan, Devesh; Shankar, Sundaresh; Chivukula, Sudheer; Ramakrishna, Ranjith; Murthy, Shanmugam Thandava; Pai, Harish Venkatraman; Sengupta, Nilanjan; Melarkode, Ramakrishnan; Iyer, Harish, Orally administrable solid pharmaceutical composition and a process thereof.
    상세보기
  33. Soltero, Richard; Ekwuribe, Nnochiri N.; Opawale, Foyeke; Rehlaender, Bruce; Hickey, Anthony; Bovet, Li Li, Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith.
    상세보기
  34. Soltero,Richard; Ekwuribe,Nnochiri N.; Opawale,Foyeke; Rehlaender,Bruce; Hickey,Anthony; Bovet,Li Li, Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith.
    상세보기
  35. Soltero, Richard; Radhakrishan, Balasingam; Ekwuribe, Nnochiri N.; Rehlaender, Bruce; Hickey, Anthony; Bovet, Li Li, Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith.
    상세보기
  36. Soltero,Richard; Radhakrishan,Balasingam; Ekwuribe,Nnochiri N.; Rehlaender,Bruce; Hickey,Anthony; Bovet,Li Li, Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith.
    상세보기
  37. Nadenik, Petr; Wagner, Helmut, Precipitation process of 7-aminocephalosporanic acid (7-ACA).
    상세보기
  38. Radhakrishnan, Balasingam; Soltero, Richard; Ekwuribe, Nnochiri N., Proinsulin polypeptide-oligomer conjugates.
    상세보기
  39. B?ckstr?m, Kjell G?ran Erik; Dahlb?ck, Carl Magnus Olof; Edman, Peter; Johansson, Ann Charlotte Birgit, Systemic administration of a therapeutic preparation.
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