초록 ▼

Crosslinked polymer compositions comprise a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple electrophilic groups. The first synthetic polymer is preferably a synthetic polypeptide or a polyethylene glycol that has bee

Crosslinked polymer compositions comprise a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple electrophilic groups. The first synthetic polymer is preferably a synthetic polypeptide or a polyethylene glycol that has been modified to contain multiple nucleophilic groups, such as primary amino (--NH.sub.2) or thiol (--SH) groups. The second synthetic polymer may be a hydrophilic or hydrophobic synthetic polymer which contains, or has been derivatized to contain, two or more electrophilic groups, such as succinimidyl groups. The compositions may further comprise other components, such as naturally occurring polysaccharides or proteins (such as glycosaminoglycans or collagen) and/or biologically active agents. Also disclosed are methods for using the crosslinked polymer compositions to effect adhesion between a first surface and a second surface; to effect tissue augmentation; to prevent the formation of surgical adhesions; and to coat a surface of a synthetic implant.

대표청구항 ▼

[ What is claimed is:] [1.] A method of forming a three dimensional synthetic polymer matrix on a first tissue surface, comprising the steps of:(a) providing a first synthetic polymer containing m nucleophilic groups and a second synthetic polymer containing n electrophilic groups, wherein the elect

[ What is claimed is:] [1.] A method of forming a three dimensional synthetic polymer matrix on a first tissue surface, comprising the steps of:(a) providing a first synthetic polymer containing m nucleophilic groups and a second synthetic polymer containing n electrophilic groups, wherein the electrophilic groups react with the nucleophilic groups to form covalent bonds therewith, wherein m and n are each greater than or equal to two, and wherein m+n is greater than or equal to five;(b) contacting the first synthetic polymer and the second synthetic polymer to initiate crosslinking; and(c) simultaneous with or subsequent to step (b), applying the first synthetic polymer and the second synthetic polymer to the first tissue surface; and(d) allowing the first synthetic polymer and the second synthetic polymer to become crosslinked to one another to form a three dimensional matrix.