초록 ▼

An iontophoresis system includes a transdermal patch for placement against the skin of a patient and a controller electrically connected to the patch. The patch includes an anode and cathode electrode, and holds an electrolyte and a medication. The controller includes a DC--DC converter circuit whic

An iontophoresis system includes a transdermal patch for placement against the skin of a patient and a controller electrically connected to the patch. The patch includes an anode and cathode electrode, and holds an electrolyte and a medication. The controller includes a DC--DC converter circuit which generates an output voltage that is provided to the anode electrode. The controller also includes an adjustable current regulator circuit. The current regulator circuit is coupled to the cathode electrode and is adjustable to provide a desired current flow through the electrodes and the skin of the patient. The DC--DC converter circuit is responsive to the voltage drop across the electrodes and adjusts its output voltage in response to this voltage drop and changes in the impedance of the patient's skin.

대표청구항 ▼

[ What is claimed is:] [1.] An iontophoresis system control circuit for use with an iontophoretic drug delivery device, the iontophoretic drug delivery device being placeable against the skin of a patient and having at least first and second electrodes, the control circuit comprising:a series pass r

[ What is claimed is:] [1.] An iontophoresis system control circuit for use with an iontophoretic drug delivery device, the iontophoretic drug delivery device being placeable against the skin of a patient and having at least first and second electrodes, the control circuit comprising:a series pass regulator circuit, the series pass regulator circuit being responsive to a control voltage and controlling a desired drug delivery current in response thereto, the desired drug delivery current being flowable through the at least first and second electrodes and the skin of the patient, the series pass regulator circuit having a voltage Vs thereacross, the series pass regulator circuit being electrically coupled to the at least second electrode of the iontophoretic drug delivery device;a step-up DC--DC converter circuit, the step-up DC--DC converter circuit being electrically coupled to the at least first electrode and generating an output voltage V2 which is provided thereto, the impedance of at least one of the iontophoretic drug delivery device and the patient's skin and the desired drug delivery current flowing therethrough resulting in a voltage drop Vp across the at least first and second electrodes, wherein the voltage V2 is equal to the sum of the voltage Vp and the voltage Vs, the DC--DC converter circuit being responsive to the voltage Vp across the at least first and second electrodes and adjusting the output voltage V2 in response thereto so that the voltage Vs across the series pass regulator is substantially equal to the minimum voltage required to allow the series pass regulator to control the desired drug delivery current through the at least first and second electrodes and the patient's skin;wherein the step-up DC--DC converter circuit includes:a step-up switching regulator circuit, the step-up switching regulator circuit generating an output signal;a first switching transistor, the first switching transistor being responsive to the output signal of the step-up switching regulator circuit and switching between a conducting and non-conducting state in response thereto;an inductor, the inductor being responsive to the state of the first switching transistor and storing energy in response thereto, the inductor having a tap and generating an output signal on the tap; anda second transistor, the second transistor being coupled to the tap of the inductor and being responsive to the output signal on the tap of the inductor, and switching between a conducting and non- conducting state in response thereto, the second transistor providing at least in part the output voltage V2.