초록

The present invention provides a miniaturized integrated nucleic acid diagnostic device and system which includes a nucleic acid extraction zone including nucleic acid binding sites.

대표청구항 ▼

[ What is claimed is:] [1.] A nucleic acid extraction device, comprising:a body having at least one chamber with at least one inlet channel;a porous flow-through deformable plug disposed within the chamber, the deformable plug having nucleic acid binding properties; anda flexible diaphragm for compr

[ What is claimed is:] [1.] A nucleic acid extraction device, comprising:a body having at least one chamber with at least one inlet channel;a porous flow-through deformable plug disposed within the chamber, the deformable plug having nucleic acid binding properties; anda flexible diaphragm for compressing said plug thereby removing trapped liquids. [3.] A nucleic acid extraction device, comprising:a body having at least one chamber with at least one inlet channel, wherein the chamber comprises a textured interior wall surface having nucleic acid binding properties;a porous flow-through plug disposed within the chamber, the plug having nucleic acid binding properties, anda piezoelectric crystal adapted to acoustically agitate a nucleic acid sample, and wherein the piezoelectric crystal is mounted to the chamber opposite the textured interior wall surface of the chamber. [4.] A biological sample refinement device, comprising:a body having at least one microchamber with at least one inlet channel;a structure disposed within the microchamber, the structure having binding sites thereon; anda fluid distribution system for delivering a biological sample into the microchamber such that at least a portion of the sample contacts the binding sites, the fluid distribution system being adapted to deliver an adjustable volume of metered elution buffer into the microchamber.