초록 ▼

One aspect of the present invention is a multi-well platform for fluorescence measurements, comprising a plurality of wells within a frame, wherein the multi-well platform has low fluorescence background. Another aspect of the present invention is a system for spectroscopic measurements, comprising

One aspect of the present invention is a multi-well platform for fluorescence measurements, comprising a plurality of wells within a frame, wherein the multi-well platform has low fluorescence background. Another aspect of the present invention is a system for spectroscopic measurements, comprising reagents for an assay and a multi-well platform for fluorescence measurements. A further aspect of the present invention is a method for detecting the presence of an analyte in a sample contained in a multi-well platform by detecting light emitted from the sample. Another aspect of the present invention is a method from identifying a modulator of a biological process or target in a sample contained in a multi-well platform by detecting light emitted from the sample. Another aspect of the present invention is a composition identified by this method. A further aspect of the present invention is a method to identify a therapeutic. A further aspect of the present invention is a method of testing a therapeutic for therapeutic activity and toxicology by identifying a therapeutic using a method of the present invention and monitoring the toxicology and efficacy of the therapeutic in an in vivo model.

대표청구항 ▼

[ We claim:] [1.] A multi-well platform, comprising:a) a plurality of wells, each well comprising:i) a wall having less fluorescence than a polystyrene-wall of at least about 90 percent of said wall's thickness, andii) a bottom having a high transmittance portion and having less fluorescence than a

[ We claim:] [1.] A multi-well platform, comprising:a) a plurality of wells, each well comprising:i) a wall having less fluorescence than a polystyrene-wall of at least about 90 percent of said wall's thickness, andii) a bottom having a high transmittance portion and having less fluorescence than a polystyrene-bottom of at least about 90 percent of said bottom's thickness, said bottom having a thickness less than about 450 microns and said bottom produces about 200 percent or less of the fluorescence compared to fused silica glass of 100 microns thickness at excitation wavelengths between about 300 to 400 nm and at emission wavelengths between about 300 to 800 nm;b) a frame, wherein said wells are disposed in said frame.