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Antisense modulation of BCL-X expression 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C07H-021/02
  • C07H-021/04
  • C12N-015/85
  • C12N-015/86
  • C12Q-001/68
  • A61K-031/70
출원번호 US-0167921 (1998-10-07)
발명자 / 주소
  • Bennett C. Frank
  • Dean Nicholas M.
  • Monia Brett P.
  • Nickoloff Brian J.
  • Zhang QingQing
출원인 / 주소
  • Isis Pharmaceuticals Inc.
대리인 / 주소
    Law Offices of Jane Massey Licata
인용정보 피인용 횟수 : 172  인용 특허 : 7

초록 ▼

Compositions and methods are provided for modulating the expression of bcl-x. Antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding bcl-x are preferred. Methods of using these compounds for modulation of bcl-x expression and for treatment of diseases associ

대표청구항 ▼

[ What is claimed is:] [1.] An antisense compound 8 to 30 nucleotides in length targeted to a nucleic acid molecule encoding a human bcl-x, wherein said antisense compound modulates the expression of human bcl-x, and wherein said antisense compound is an antisense oligonucleotide which comprises at

이 특허에 인용된 특허 (7)

  1. Gibbons Gary H. ; Pollman Matthew J., Apoptotic regression of intimal vascular lesions.
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  3. Metelev Valeri (Shrewsbury MA) Agrawal Sudhir (Shrewsbury MA), Hybrid oligonucleotide phosphorothioates.
    상세보기
  4. Agrawal Sudhir, Oligonucleotides having modified CpG dinucleosides.
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  5. Summerton, James E.; Weller, Dwight D., Uncharged morpholino-based polymers having achiral intersubunit linkages.
    상세보기
  6. Thompson Craig B. (Chicago IL) Boise Lawrence H. (Chicago IL) Nunez Gabriel (Ann Arbor MI), Vertebrate apoptosis gene: compositions and methods.
    상세보기
  7. Thompson Craig B. ; Boise Lawrence H. ; Nunez Gabriel, Vertebrate apoptosis gene: compositions and methods.
    상세보기

이 특허를 인용한 특허 (172)

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  118. Khvorova, Anastasia; Reynolds, Angela; Leake, Devin; Marshall, William; Scaringe, Stephen; Read, Steven, siRNA targeting BCL2L1.
    상세보기
  119. Khvorova, Anastasia; Reynolds, Angela; Leake, Devin; Marshall, William; Scaringe, Stephen; Read, Steven, siRNA targeting KRAS.
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  120. Khvorova, Anastasia; Reynolds, Angela; Leake, Devin; Marshall, William; Scaringe, Stephen; Read, Steven, siRNA targeting KRAS.
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  121. Khvorova, Anastasia; Reynolds, Angela; Leake, Devin; Marshall, William; Read, Steven; Scaringe, Stephen, siRNA targeting TATA box binding protein (TBP)-associated factor (TAF1).
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  122. Khvorova, Anastasia; Reynolds, Angela; Leake, Devin; Marshall, William; Read, Steven; Scaringe, Stephen, siRNA targeting TATA box binding protein (TBP)-associated factor (TAF1).
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  123. Khvorova, Anastasia; Reynolds, Angela; Leake, Devin; Marshall, William; Read, Steven; Scaringe, Stephen, siRNA targeting TATA box binding protein (TBP)-associated factor (TAF1).
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  124. Khvorova, Anastasia; Reynolds, Angela; Leake, Devin; Marshall, William; Read, Steven; Scaringe, Stephen, siRNA targeting TIE-2.
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  125. Khvorova, Anastasia; Reynolds, Angela; Leake, Devin; Marshall, William; Read, Steven; Scaringe, Stephen, siRNA targeting TIE-2.
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  126. Khvorova, Anastasia; Reynolds, Angela; Leake, Devin; Marshall, William; Read, Steven; Scaringe, Stephen, siRNA targeting TNFα.
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  127. Khvorova, Anastasia; Reynolds, Angela; Leake, Devin; Marshall, William; Read, Steven; Scaringe, Stephen, siRNA targeting amyloid beta (A4) precursor protein (APP).
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  128. Khvorova, Anastasia; Reynolds, Angela; Leake, Devin; Marshall, William; Read, Steven; Scaringe, Stephen, siRNA targeting amyloid beta (A4) precursor protein (APP).
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  129. Khvorova, Anastasia; Reynolds, Angela; Leake, Devin; Marshall, William; Read, Steven; Scaringe, Stephen, siRNA targeting apolipoprotein B (APOB).
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  130. Khvorova, Anastasia; Reynolds, Angela; Leake, Devin; Marshall, William; Read, Steven; Scaringe, Stephen, siRNA targeting beta secretase (BACE).
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  131. Khvorova, Anastasia; Reynolds, Angela; Leake, Devin; Marshall, William; Read, Steven; Scaringe, Stephen, siRNA targeting cAMP-specific phosphodiesterase 4D.
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  132. Khvorova, Anastasia; Reynolds, Angela; Leake, Devin; Marshall, William; Read, Steven; Scaringe, Stephen, siRNA targeting casitas B cell lymphoma-B (CBL-B).
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  133. Khvorova, Anastasia; Reynolds, Angela; Leake, Devin; Marshall, William; Read, Steven; Scaringe, Stephen, siRNA targeting coatomer protein complex, subunit beta 2 (COPB2).
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  134. Khvorova, Anastasia; Reynolds, Angela; Leake, Devin; Marshall, William; Read, Steven; Scaringe, Stephen, siRNA targeting complement component 3 (C3).
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  135. Khvorova, Anastasia; Reynolds, Angela; Leake, Devin; Marshall, William; Scaringe, Stephen; Read, Steven, siRNA targeting complement factor B.
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  136. Khvorova, Anastasia; Reynolds, Angela; Leake, Devin; Marshall, William; Read, Steven; Scaringe, Stephen, siRNA targeting connective tissue growth factor (CTGF).
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  137. Khvorova, Anastasia; Reynolds, Angela; Leake, Devin; Marshall, William; Read, Steven; Scaringe, Stephen, siRNA targeting connective tissue growth factor (CTGF).
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  138. Khvorova, Anastasia; Reynolds, Angela; Leake, Devin; Marshall, William; Read, Steven; Scaringe, Stephen, siRNA targeting connective tissue growth factor (CTGF).
    상세보기
  139. Khvorova, Anastasia; Reynolds, Angela; Leake, Devin; Marshall, William; Read, Steven; Scaringe, Stephen, siRNA targeting cyclin dependent kinase 11 (CDK11).
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  140. Khvorova, Anastasia; Reynolds, Angela; Leake, Devin; Marshall, William; Read, Steven; Scaringe, Stephen, siRNA targeting cyclin-dependent kinase 4 (CDK4).
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  141. Khvorova, Anastasia; Reynolds, Angela; Leake, Devin; Marshall, William; Read, Steven; Scaringe, Stephen, siRNA targeting cyclin-dependent kinase inhibitor 1B (p27, Kip1) (CDKN1B).
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  142. Khvorova, Anastasia; Reynolds, Angela; Leake, Devin; Marshall, William; Read, Steven; Scaringe, Stephen, siRNA targeting cyclin-dependent kinase inhibitor 1B (p27, Kip1) (CDKN1B).
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  143. Khvorova, Anastasia; Reynolds, Angela; Leake, Devin; Marshall, William; Read, Steven; Scaringe, Stephen, siRNA targeting diacylglycerol O-acyltransferase homolog 2 (DGAT2).
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  144. Khvorova, Anastasia; Reynolds, Angela; Leake, Devin; Marshall, William; Read, Steven; Scaringe, Stephen, siRNA targeting gremlin.
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  145. Khvorova, Anastasia; Reynolds, Angela; Leake, Devin; Marshall, William; Read, Steven; Scaringe, Stephen, siRNA targeting gremlin.
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  146. Khvorova, Anastasia; Reynolds, Angela; Leake, Devin; Marshall, William; Read, Steven; Scaringe, Stephen, siRNA targeting histamine receptor H1.
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  147. Khvorova, Anastasia; Reynolds, Angela; Leake, Devin; Marshall, William; Read, Steven; Scaringe, Stephen, siRNA targeting histamine receptor H1.
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  148. Khvorova, Anastasia; Reynolds, Angela; Leake, Devin; Marshall, William; Read, Steven; Scaringe, Stephen, siRNA targeting hypoxia-inducible factor 1.
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  149. Khvorova, Anastasia; Reynolds, Angela; Leake, Devin; Marshall, William; Read, Steven; Scaringe, Stephen, siRNA targeting interleukin-1 receptor-associated kinase 4 (IRAK4).
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  150. Khvorova, Anastasia; Reynolds, Angela; Leake, Devin; Marshall, William; Read, Steven; Scaringe, Stephen, siRNA targeting interleukin-1 receptor-associated kinase 4 (IRAK4).
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  151. Khvorova, Anastasia; Reynolds, Angela; Leake, Devin; Marshall, William; Read, Steven; Scaringe, Stephen, siRNA targeting interleukin-1 receptor-associated kinase 4(IRAK4).
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  152. Khvorova, Anastasia; Reynolds, Angela; Leake, Devin; Marshall, William; Read, Steven; Scaringe, Stephen, siRNA targeting kinase insert domain receptor (KDR).
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  153. Khvorova, Anastasia; Reynolds, Angela; Leake, Devin; Marshall, William; Read, Steven; Scaringe, Stephen, siRNA targeting kinase insert domain receptor (KDR).
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  154. Khvorova, Anastasia; Reynolds, Angela; Leake, Devin; Marshall, William; Scaringe, Stephen; Read, Steven, siRNA targeting myeloid cell leukemia sequence 1.
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  155. Khvorova, Anastasia; Reynolds, Angela; Leake, Devin; Marshall, William; Read, Steven; Scaringe, Stephen, siRNA targeting nucleoporin 62kDa (Nup62).
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  156. Khvorova, Anastasia; Reynolds, Angela; Leake, Devin; Marshall, William; Read, Steven; Scaringe, Stephen, siRNA targeting polo-like kinase-1 (PLK-1).
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  157. Khvorova, Anastasia; Reynolds, Angela; Leake, Devin; Marshall, William; Read, Steven; Scaringe, Stephen, siRNA targeting protein kinase N-3 (PKN-3).
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  158. Khvorova, Anastasia; Reynolds, Angela; Leake, Devin; Marshall, William; Read, Steven; Scaringe, Stephen, siRNA targeting proto-oncogene MET.
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  159. Khvorova, Anastasia; Reynolds, Angela; Leake, Devin; Marshall, William; Read, Steven; Scaringe, Stephen, siRNA targeting proto-oncogene MET.
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  160. Khvorova, Anastasia; Reynolds, Angela; Leake, Devin; Marshall, William; Read, Steven; Scaringe, Stephen, siRNA targeting ribonucleotide reductase M2 polypeptide (RRM2 or RNR-R2).
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  161. Khvorova, Anastasia; Reynolds, Angela; Leake, Devin; Marshall, William; Read, Steven; Scaringe, Stephen, siRNA targeting serine/threonine kinase 12 (STK12 or aurora B kinase).
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  162. Khvorova, Anastasia; Reynolds, Angela; Leake, Devin; Marshall, William; Read, Steven; Scaringe, Stephen, siRNA targeting serine/threonine kinase 12 (STK12 or aurora B kinase).
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  163. Khvorova, Anastasia; Reynolds, Angela; Leake, Devin; Marshall, William; Scaringe, Stephen, siRNA targeting spleen tyrosine kinase.
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  164. Khvorova, Anastasia; Reynolds, Angela; Leake, Devin; Marshall, William; Scaringe, Stephen; Read, Steven, siRNA targeting spleen tyrosine kinase.
    상세보기
  165. Khvorova, Anastasia; Reynolds, Angela; Leake, Devin; Marshall, William; Read, Steven; Scaringe, Stephen, siRNA targeting superoxide dismutase 1 (SOD1).
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  166. Khvorova, Anastasia; Reynolds, Angela; Leake, Devin; Marshall, William; Read, Steven; Scaringe, Stephen, siRNA targeting superoxide dismutase 1 (SOD1).
    상세보기
  167. Khvorova, Anastasia; Reynolds, Angela; Leake, Devin; Marshall, William; Scaringe, Stephen; Read, Steven, siRNA targeting survivin.
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  168. Khvorova, Anastasia; Reynolds, Angela; Leake, Devin; Marshall, William; Scaringe, Stephen; Read, Steven, siRNA targeting survivin.
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  169. Khvorova, Anastasia; Reynolds, Angela; Leake, Devin; Marshall, William; Read, Steven; Scaringe, Stephen, siRNA targeting tie-2.
    상세보기
  170. Khvorova, Anastasia; Reynolds, Angela; Leake, Devin; Marshall, William; Read, Steven; Scaringe, Stephen, siRNA targeting transducin (beta)-like 3 (TBL3).
    상세보기
  171. Khvorova, Anastasia; Reynolds, Angela; Leake, Devin; Marshall, William; Read, Steven; Scaringe, Stephen, siRNA targeting transient receptor potential cation channel, subfamily V, member 1 (TRPV1).
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  172. Khvorova, Anastasia; Reynolds, Angela; Leake, Devin; Marshall, William; Read, Steven; Scaringe, Stephen, siRNA targeting tumor protein 53 (p53).
    상세보기

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