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Antigens embedded in thermoplastic 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • G01N-033/543
출원번호 US-0909889 (1997-08-12)
발명자 / 주소
  • McIntyre John A.
대리인 / 주소
    Antonelli, Terry, Stout & Kraus, LLP
인용정보 피인용 횟수 : 28  인용 특허 : 42

초록

The invention relates to an immunoassays, binding assays, solid phase substrates (12) and other devices with an antigen or antibody or ligand or receptor (11) embedded into a solid phase substrate (12). The antigen or antibody is mixed with a molten thermoplastic and formed into the solid phase subs

대표청구항

[ What is claimed is:] [2.] A binding agent-containing monolithic solid material having a binding agent evenly dispersed throughout a monolithic solid material, wherein the binding agent is not chemically coupled to the monolithic solid material, wherein the binding agent comprises a lipid or phosph

이 특허에 인용된 특허 (42)

  1. Smirnov Mikhail D. (Oklahoma City OK) Esmon Charles T. (Oklahoma City OK), Assay for detection of selective Protein C inhibition by patients.
  2. Yokohari Ryuichi (Matsudo JPX) Aotsuka Shinichi (Shonan JPX) Kinoshita Makiko (Tokyo JPX) Funahashi Takashi (Kobe JPX) Tani Nobutaka (Osaka JPX), Autoantibody adsorbent and apparatus for removing autoantibodies using the same.
  3. Farmilo A. James (Oakville CAX) Stead Ronald H. (Dundas CAX), Automated histo-cytochemistry apparatus and encapsulation system for processing biological materials.
  4. Nerbe Jrgen F. (Ansgarstrasse 8 D-2105 Seevetal 11 DEX) Wnne Karl-Georg (Zum dicken Busch 12b D-2000 Barsttel DEX), Biochemical reaction receptacle.
  5. Dunn Richard L. (Fort Collins CO) Tipton Arthur J. (Fort Collins CO) Southard George L. (Fort Collins CO) Rogers Jack A. (Fort Collins CO), Biodegradable polymer composition.
  6. Nugent Edward L. (North Caldwell NJ), Body fluid sample collection tube composite.
  7. Matsuura Eiji (Choshi JPX) Igarashi Yoshiko (Choshi JPX) Nagae Hisato (Choshi JPX), Carrier for binding of anti-phospholipid antibodies, and immunoassay method using the same and a kit therefor.
  8. Stanley Theodore H. ; Hague Brian, Compositions and methods of manufacturing of oral dissolvable medicaments.
  9. Stanley Theodore H. (Salt Lake City UT) Hague Brian (West Valley City UT), Compositions of oral dissolvable medicaments.
  10. Lostia Onofrio (Rome IT) Bartoli Francesco (Rome IT), Fibres incorporating antibodies, antigens and antisera, method for their preparation and their use.
  11. Provonchee Richard B. (Camden ME) Kirkpatrick Francis H. (Owls Head ME), Gel-in-matrix containing a fractured hydrogel.
  12. Yabusaki Kenichi K. (Albany CA), Immunoassay of phospholipid, such as phosphatidyl choline, in fluids such as amniotic.
  13. Sharma Yash (2766 January Cts. Falls Church VA 22043), Immunoassay with solid phase having coating containing blood platelet substitute.
  14. Peters ; Jr. Donald F. (Campbell CA) Dumont Lawrence C. (Santa Cruz CA), Mass producible biologically active solid phase devices.
  15. Jozefonvicz ne Dorgebray Jacqueline (Lamorlaye FRX) Santarelli Xavier-Francois (Orleans FRX) Muller Daniel A. (Soisy-sous-Montmorency FRX), Materials capable of binding biological substances, and its applications, in particular, as in an affinity chromatograph.
  16. Baldo Brian A. (Pymble AUX) Tovey Euan R. (Petersham AUX), Medical testing device with calibrated indicia.
  17. Pall David B. (Roslyn Estates NY), Melt-blown fibrous web.
  18. Ramanujam Rama P. (Brookfield WI) Burdick Brent A. (Brookfield WI) Landegren Ulf D. (Upsala SEX) Sevigny Pierre (Upsala SEX), Method and preparation for sequential delivery of wax-embedded, inactivated biological and chemical reagents.
  19. Wittwer Fritz (Lupsingen CHX) Tomka Ivan (Lenzburg CHX) Bodenmann Hans-Ulrich (Mnchenstein CHX) Raible Thomas (Jona NJ CHX) Gillow Louis S. (Rockaway NJ), Method for forming pharmaceutical capsules from starch compositions.
  20. Fischer Lutz (Ludwigstrasse 18 D-3300 Braunschweig DEX) Mller Ralf (Gorch-Fock Strasse 25 D-2359 Henstedt-Ulzburg DEX) Mosbach Klaus (Lackalnga 31 P1 5548 ; S-244 94 Furulund SEX) Ekberg Bjrn (Vinstr, Method for separating enantiomers of aryloxipropanolamine derivatives, and chiral solid-phase chromatography material fo.
  21. Krilis Steven A. (Hunter\s Hill AUX) McNeill Hugh P. (Jannali AUX) Chesterman Colin N. (Bellevue Hill AUX), Methods for determining anti-phospholipid and anti-cardiolipin antibodies.
  22. Sutton Richard C. (Rochester NY), Methods of preparing a polymeric latex composition and water-insoluble biological reagent.
  23. Mosbach Klaus,SEX ; Mayes Andrew G.,GB2, Molecularly imprinted beaded polymers and stabilized suspension polymerization of the same in perfluorocarbon liquids.
  24. Walter Bert (South Bend IN), Multilayer analytical element having an impermeable radiation diffusing and blocking layer.
  25. Johnson Richard D. (Elkhart IN) Runzheimer H. Volker (Bergisch Gladbach IN DEX) Sommer Ronald G. (Elkhart IN) Yip Kin F. (Elkhart IN), Polyacrylamide gel particles having hapten moieties bound thereto as immunoassay reagent.
  26. Fisk Donald, Polymer composition containing prime starch.
  27. Wittwer Fritz (Lupsingen CHX) Tomka Ivan (Bourguillon CHX), Polymer composition for injection molding.
  28. Usala Anton-Lewis (South Euclid OH), Polymeric substrates containing povidone-iodine as a control release biologically active agent.
  29. Mosbach Klaus (Lackalnga 31-18 S-240 20 Furulund SEX), Preparation of synthetic enzymes and synthetic antibodies and use of the thus prepared enzymes and antibodies.
  30. Kosak Kenneth M. (3194 S. 4400 W. West Valley City UT 84120) Kosak Matthew K. (3194 S. 4400 W. West Valley City UT 84120), Preparation of wax beads containing a reagent for release by heating.
  31. Kosak Kenneth M. (3194 S. 4400 West West Valley City UT 84120) Kosak Matthew K. (3194 S. 4400 West West Valley City UT 84120), Preparation of wax beads containing a reagent using liquid nitrogen for cooling and solidifying.
  32. Wang Lynn (Jerusalem ILX) Inbar Michael (Mazkeret Batya ILX), Preparations for use in solid phase immunoassays comprising monoclonal antibodies covalently embedded in their immobiliz.
  33. Hartdegen Frank J. (Columbia MD) Swann Wayne E. (Pasadena MD), Process for immobilizing proteins.
  34. Bonacker ; Ludwig ; Stark ; Josef, Process for the manufacture of polystyrene latex compounds.
  35. Donofrio David A. ; Stedronsky Erwin R., Protein-enriched thermoplastics.
  36. Donofrio David M. ; Stedronsky Erwin R., Protein-enriched thermoplastics.
  37. Swan Dale G. (St. Louis Park MN) Hastings Charles A. (Hopkins MN), Restrained multifunctional reagent for surface modification.
  38. Lim Franklin (Richmond VA), Reversible microencapsulation of a core material.
  39. Mosbach Klaus,CHX ; Mayes Andrew G.,GB2, Stabilizers, polymers, and emulsions useful for molecular imprinting technology.
  40. DeFilippi Louis J. (Cook IL), Support containing particulate adsorbent and microorganisms for removal of pollutants.
  41. Nowinski Robert C. (Seattle WA) Hoffman Allan S. (Seattle WA) Houghton Raymond L. (Kirkland WA) Priest John H. (Everett WA) Monji Nobuo (Seattle WA), Synthesis and use of polymers containing integral binding-pair members.
  42. Nowinski Robert C. (King County WA) Hoffman Allan S. (King County WA), Synthesis of polymers containing integral antibodies.

이 특허를 인용한 특허 (28)

  1. Warren, William L.; Fahlenkamp, Heather; Higbee, Russell; Kachurin, Anatoly; Li, Conan; Nguyen, Mike; Parkhill, Robert; Sanchez-Schmitz, Guzman; Irvine, Darrell J.; Randolph, Gwendalyn J.; Hacohen, Nir; Torbett, Bruce, Artificial immune system: methods for making and use.
  2. Warren, William L; Fahlenkamp, Heather; Higbee, Russell; Kachurin, Anatoly; Li, Conan; Nguyen, Mike; Parkhill, Robert; Sanchez-Schmitz, Guzman; Irvine, Darrell J.; Randolph, Gwendalyn J.; Harcohen, Nir; Torbett, Bruce, Artificial immune system: methods for making and use.
  3. Warren, William L; Fahlenkamp, Heather; Higbee, Russell; Kachurin, Anatoly; Li, Conan; Nguyen, Mike; Parkhill, Robert; Sanchez-Schmitz, Guzman; Irvine, Darrell J.; Randolph, Gwendalyn J.; Hacohen, Nir; Torbett, Bruce, Artificial immune system: methods of use.
  4. Warren, William L; Fahlenkamp, Heather; Higbee, Russell; Kachurin, Anatoly; Li, Conan; Nguyen, Mike; Parkhill, Robert; Sanchez-Schmitz, Guzman; Irvine, Darrell J.; Randolph, Gwendalyn J.; Harcohen, Nir; Torbett, Bruce, Artificial immune system: methods of use.
  5. Sanchez-Schmitz, Guzman; Higbee, Russell; Fahlenkamp, Heather; Irvine, Darrell J.; Warren, William L.; Drake, III, Donald, Artificial lymphoid tissue equivalent.
  6. Mahmood, Ayesha; Kachurin, Anatoly; Warren, William; Higbee, Russell, Artificial tissue constructs comprising alveolar cells and methods for using the same.
  7. Mahmood, Ayesha; Kachurin, Anatoly; Warren, William; Higbee, Russell, Artificial tissue constructs comprising alveolar cells and methods for using the same.
  8. Warren, William L.; Parkhill, Robert; Nguyen, Michael N.; Sanchez-Schmitz, Guzman; Fahlenkamp, Heather; Higbee, Russell; Drake, III, Donald; Kachurin, Anatoly; Moe, David, Automatable artificial immune system (AIS).
  9. Granchelli, Joesph; Cummins, Thomas, Cell culture surface chemistries.
  10. Wojtczak,William A.; Dewulf,Dean; Collins,Sian, Cleaning solutions and etchants and methods for using same.
  11. Warren, William L.; Fahlenkamp, Heather; Higbee, Russell G.; Mishkin, Eric M.; Sanchez-Schmitz, Guzman; Rivard, Michael D.; Pawar, Santosh, Disease model incorporation into an artificial immune system (AIS).
  12. Warren, William L.; Higbee, Russell; Mishkin, Eric; Sanchez-Schmitz, Guzman; Fahlenkamp, Heather; Rivard, Michael, Disease model incorporation into an artificial immune system (AIS).
  13. Warren, William L.; Higbee, Russell; Mishkin, Eric; Sanchez-Schmitz, Guzman; Fahlenkamp, Heather; Rivard, Michael, Disease model incorporation into an artificial immune system (AIS).
  14. Sukumar, Selva; El Shikh, Mohey Eldin M.; Tew, John G.; Sanchez-Schmitz, Guzman; Drake, III, Donald; Mosquera, Luis; Li, Conan; Kachurin, Anatoly M.; Higbee, Russell; Fahlenkamp, Heather; Mishkin, Eric; Warren, William L., In vitro germinal centers.
  15. Sukumar, Selva; El Shikh, Mohey Eldin M.; Tew, John G.; Sanchez-Schmitz, Guzman; Drake, III, Donald; Mosquera, Luis; Mishkin, Eric; Kachurin, Anatoly M.; Higbee, Russell; Li, Conan; Warren, William L.; Fahlenkamp, Heather, In vitro germinal centers.
  16. Shepard,Douglas C., Medical articles having enzymatic surfaces for localized therapy.
  17. Warren, William L.; Drake, III, Donald; Moser, Janice; Singh, Inderpal; Song, Haifeng; Mishkin, Eric, Method for determining the immunogenicity of an antigen.
  18. Warren, William L.; Parkhill, Robert; Nguyen, Michael N.; Sanchez-Schmitz, Guzman; Fahlenkamp, Heather; Higbee, Russell; Drake, III, Donald; Kachurin, Anatoly; Moe, David, Methods for antibody production.
  19. Sukumar, Selva; El Shikh, Mohey Eldin M.; Tew, John G.; Sanchez-Schmitz, Guzman; Drake, III, Donald; Mosquera, Luis; Li, Conan; Kachurin, Anatoly M.; Higbee, Russell; Fahlenkamp, Heather; Mishkin, Eric; Warren, William L., Methods for assaying responses to vaccines.
  20. Warren, William L.; Drake, III, Donald; Moser, Janice; Singh, Inderpal; Song, Haifeng; Mishkin, Eric; Tew, John G., Methods for testing an immune response using cultures of T cells, B cells and dendritic cells.
  21. Warren, William L.; Drake, III, Donald; Moser, Janice; Singh, Inderpal; Song, Haifeng; Mishkin, Eric; Tew, John G., Methods for testing an immune response using cultures of T cells, B cells, dendritic cells and follicular dendritic cells.
  22. Warren, William L.; Fahlenkamp, Heather; Higbee, Russel G.; Mishkin, Eric M.; Sanchez-Schmitz, Guzman; Rivard, Michael D.; Pawar, Santosh, Methods of evaluating a test agent in a diseased cell model.
  23. Warren, William L.; Fahlenkamp, Heather; Higbee, Russell G.; Mishkin, Eric M.; Sanchez-Schmitz, Guzman; Rivard, Michael D.; Pawar, Santosh, Methods of evaluating a test agent in a diseased cell model.
  24. Sukumar, Selva; El Shikh, Mohey Eldin M.; Tew, John G.; Sanchez-Schmitz, Guzman; Drake, III, Donald; Mosquera, Luis; Li, Conan; Kachurin, Anatoly M.; Higbee, Russell; Fahlenkamp, Heather; Mishkin, Eric; Warren, William L., Methods of evaluating an immune response to an antigen.
  25. Anderson, Norman G.; Anderson, N. Leigh, Microarrays and their manufacture.
  26. Tew, John G.; El Shikh, Mohey Eldin M.; Singh, Inderpal; Mishkin, Eric; Drake, III, Donald; Song, Haifeng; Warren, William L, Models for vaccine assessment.
  27. McIntyre,John A., Nucleic acid antigens embedded in thermoplastic.
  28. Stewart, Ray F., Phase change sensor.
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