초록 ▼

The present invention includes a method for producing an implantable polymer/drug matrix mass, comprising the steps of (1) forming a polymer solution/drug mixture comprising a polymer dissolved in an organic solvent and a suspended labile drug; (2) removing the solvent from the polymer solution/drug

The present invention includes a method for producing an implantable polymer/drug matrix mass, comprising the steps of (1) forming a polymer solution/drug mixture comprising a polymer dissolved in an organic solvent and a suspended labile drug; (2) removing the solvent from the polymer solution/drug mixture, thereby forming a solid polymer/drug matrix; and (3) mechanically compressing the polymer/drug matrix, thereby forming an implantable polymer/drug matrix mass.

대표청구항 ▼

[ What is claimed is:] [1.] A method for preparing a polymer/drug matrix mass, wherein the drug is a labile drug, consisting essentially of the steps of:(a) forming a polymer solution/drug mixture comprising a polymer dissolved in an organic solvent and a drug suspended in said solvent;(b) removing

[ What is claimed is:] [1.] A method for preparing a polymer/drug matrix mass, wherein the drug is a labile drug, consisting essentially of the steps of:(a) forming a polymer solution/drug mixture comprising a polymer dissolved in an organic solvent and a drug suspended in said solvent;(b) removing the solvent from the polymer solution/drug mixture, thereby forming a solid polymer/drug matrix;(c) fragmenting the solid polymer/drug matrix at a temperature below the glass transition temperature of the solid polymer/drug matrix, thereby forming polymer/drug matrix microparticles; and(d) compressing the polymer/drug matrix microparticles to produce a polymer/drug matrix mass.