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Formulation and devices for monitoring the efficacy of the delivery of aerosols 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61M-015/00
출원번호 US-0012857 (1998-01-23)
발명자 / 주소
  • Gonda Igor
출원인 / 주소
  • Aradigm Corporation
대리인 / 주소
    Bozicevic
인용정보 피인용 횟수 : 55  인용 특허 : 21

초록

Aerosolizable formulations are disclosed comprised of a pharmaceutically acceptable carrier, a pharmaceutically active drug or detectably labeled compound and a compound which is recognized by its distinct color, taste and/or smell even when present in a small amount and a low concentration. Example

대표청구항

[What is claimed is:] [1.]

이 특허에 인용된 특허 (21)

  1. Bolasco Franco (Rome ITX), 2-(2-Thenolythio)-propionylglycine: method for its preparation and pharmaceutical formulations containing said compound.
  2. Cupps Thomas L. (Oxford OH) Bogdan Sophie E. (Maineville OH), 5-(2-imidazolinylamino)benzimidazole compounds useful as alpha-2 andrenoceptor agonists.
  3. Goodman David E. (Brookline MA) Rubsamen Reid M. (Boston MA), Delivery of aerosol medications for inspiration.
  4. Hodson Peter D. (St. Paul MN) Smith David K. (St. Paul MN) Velasquez David J. (St. Paul MN) Wass Anthony C. L. (St. Paul MN), Dry powder inhalation device having a powder-loaded elongate carrier.
  5. Lloyd Lester J. (Orinda CA) Lloyd Peter M. (Oakland CA) Rubsamen Reid M. (Berkley CA) Schuster Jeffrey A. (Berkley CA), Dynamic particle size control for aerosolized drug delivery.
  6. Ozaki Yoshihide (Okayama JPX) Nomura Tatsuo (Okayama JPX) Miyake Toshio (Okayama JPX), High pullulan content product, and its preparation and uses.
  7. Paul Philip C. (Denver CO), Integral substance detection device and method.
  8. Rubsamen Reid M. (Berkeley CA) Lloyd Lester J. (Orinda CA) Johansson Eric T. (Dublin CA), Lockout device for controlled release of drug from patient-activateddispenser.
  9. Chilton Henry (Louisville NC) Dickson Lester (Budd Lake NJ), Method and apparatus for bolus delivery of gases and aerosols and insufflations.
  10. Patton John S. (San Carlos CA) Platz Robert M. (Half Moon Bay CA), Method and device for delivering aerosolized medicaments.
  11. Rubsamen Reid M. (Berkeley CA) Johansson Eric T. (Dublin CA), Method for releasing controlled amount of aerosol medication.
  12. Rubsamen Reid M. (Berkeley CA) Lloyd Lester John (Orinda CA), Method of administration of insulin.
  13. Petralli Louis J. (Grants Pass OR), Multisensor particle counter utilizing a single energy source.
  14. Fassberg Julianne (New York NY) Sequeira Joel A. (New York NY) Chaudry Imtiaz A. (North Caldwell NJ) Kopcha Michael (East Brunswick NJ), Non-chlorofluorocarbon aerosol formulations.
  15. Baskeyfield Lewis J. (Cheshire GB2) Jay Graham F. (Cheshire GB2) Wright Paul (Nottinghamshire GB2), Pharmaceutical inhalation compositions.
  16. Rubsamen Reid ; Gonda Igor ; Farr Stephen ; Cipolla David, Prefilter for prevention of clogging of a nozzle in the generation of an aerosol and prevention of administration of und.
  17. Knight Jack V. (Houston TX) Wilson ; Jr. Samuel Z. (Houston TX), Small particle aerosol generator for treatment of respiratory disease including the lungs.
  18. Baker Raymond (Much Hadham GB2) Matassa Victor G. (Rome ITX) Guiblin Alexander R. (Harlow GB2) Pitt Kendal G. (Hatfield GB2) Street Leslie J. (Harlow PA GB2) Olive Carole (Lansdale PA) Storey David E, Sulphate salt of a substituted triazole, pharmaceutical compositions thereof, and their use in therapy.
  19. Andersson Jan (Sodra Sandby SEX) Jagfeldt Hans (Lund SEX) Trofast Eva (Lund SEX) Wetterlin Kjell (Sodra Sandby SEX), System for dispensing pharmaceutically active compounds.
  20. Lloyd Lester J. (Orinda CA) Lloyd Peter M. (Oakland CA) Rubsamen Reid M. (Berkeley CA) Schuster Jeffrey A. (Berkeley CA), Systems for the intrapulmonary delivery of aerosolized aqueous formulations.
  21. Gonda Igor ; Rubsamen Reid M. ; Farr Stephen J., Use of monomeric insulin as a means for improving the bioavailability of inhaled insulin.

이 특허를 인용한 특허 (55)

  1. Wensley, Martin; Lloyd, Peter, Aerosol generating device.
  2. Cox, Kenneth A.; Beane, Timothy Paul; Sweeney, William R., Aerosol generator and methods of making and using an aerosol generator.
  3. Cox, Kenneth A.; Beane, Timothy Paul; Sweeney, William R.; Nichols, Walter A.; Sprinkel, Jr., F. Murphy, Aerosol generator and methods of making and using an aerosol generator.
  4. Cox,Kenneth A.; Beane,Timothy Paul; Sweeney,William R.; Nichols,Walter A.; Sprinkel, Jr.,F. Murphy, Aerosol generator and methods of making and using an aerosol generator.
  5. Sprinkel, Jr., F. Murphy; Nichols, Walter A., Aerosol generator having a multiple path heater arrangement and method of use thereof.
  6. Sherwood, Timothy S.; Sowers, Scott A.; Reddy, Sirisha P.; Sprinkel, Jr., F. Murphy; Cox, Kenneth A.; Nichols, Walter A., Aerosol generator having heater arranged to vaporize fluid in fluid passage between bonded layers of laminate.
  7. Sprinkel, Jr., F. Murphy; Nichols, Walter A.; Cox, Kenneth A.; Sherwood, Timothy S.; Sowers, Scott A.; Washington, Zelita R.; Reddy, Sirisha, Aerosol generator having heater in multilayered composite and method of use thereof.
  8. Sharpe, David E.; Felter, John L., Aerosol generator having inductive heater and method of use thereof.
  9. Kenneth A. Cox ; Walter A. Nichols ; F. Murphy Sprinkel, Jr. ; Douglas D. McRae ; William R. Sweeney, Aerosol generator having multiple heating zones and methods of use thereof.
  10. Cox,Kenneth A.; Nichols,Walter A.; Sprinkel, Jr.,F. Murphy; McRae,Douglas D.; Sweeney,William R., Aerosol generator having temperature controlled heating zone and method of use thereof.
  11. Cesak,James, Apparatus and method for detecting liquid flow from a spray device.
  12. Crowder,Timothy M.; Hickey,Anthony J.; Boekestein,Vanessa, Apparatus, systems and related methods for dispensing and /or evaluating dry powders.
  13. Crowder, Timothy M.; Hickey, Anthony J.; Boekestein, Vanessa, Apparatus, systems and related methods for processing, dispensing and/or evaluatingl dry powders.
  14. Hickey,Anthony James; Crowder,Timothy; Warden,Jeffrey Alan; Johnson,Keith Arthur; Ketner,Mark Ennis; Fording,Jay Kinsley; Garten,Michael Duane; Riley,William Myles; Anderson,Sean Derek; Ferris,Bruce Seymour; Rockwell,Paul Gilbert, Blister packages with frames and associated methods of fabricating dry powder drug containment systems.
  15. Altobelli, David E.; Gray, Larry B.; Kane, Derek G., Detection system and method for aerosol delivery.
  16. Altobelli,David E.; Gray,Larry B.; Kane,Derek G., Detection system and method for aerosol delivery.
  17. Haveri, Heikki, Device and method for detecting and controlling liquid supply to an apparatus discharging liquids.
  18. Kamen, Dean; Gray, Larry B.; Beavis, Russell H.; Kerwin, John M.; Kane, Derek G., Device to dispense fluids.
  19. Beavis, Russell H.; Gray, Larry B.; Kane, Derek G., Device to meter fluid.
  20. Nichols, Walter A.; Sprinkel, Jr., F. Murphy, Disposable aerosol generator system and methods for administering the aerosol.
  21. Nichols,Walter A.; Sprinkel, Jr.,F. Murphy, Disposable aerosol generator system and methods for administering the aerosol.
  22. Nichols,Walter A.; Sprinkel, Jr.,F. Murphy, Disposable inhaler system.
  23. Nichols,Walter A.; Sprinkel, Jr.,F. Murphy, Disposable inhaler system.
  24. Crowder,Timothy M.; Hickey,Anthony J., Dry powder dose filling systems and related methods.
  25. Crowder,Timothy M.; Hickey,Anthony J., Dry powder dose filling systems and related methods.
  26. Crowder, Timothy M.; Hickey, Anthony J.; Warden, Jeffrey A., Dry powder inhalers, related blister devices, and associated methods of dispensing dry powder substances and fabricating blister packages.
  27. Crowder, Timothy M.; Hickey, Anthony J.; Warden, Jeffrey A., Dry powder inhalers, related blister devices, and associated methods of dispensing dry powder substances and fabricating blister packages.
  28. Hickey,Anthony James; Crowder,Timothy; Warden,Jeffrey Alan; Johnson,Keith Arthur; Ketner,Mark Ennis; Fording,Jay Kinsley; Garten,Michael Duane; Riley,William Myles; Anderson,Sean Derek; Ferris,Bruce Seymour; Rockwell,Paul Gilbert, Dry powder inhalers, related blister package indexing and opening mechanisms, and associated methods of dispensing dry powder substances.
  29. Nichols, Walter A.; Cox, Kenneth A.; Nguyen, Tung Tien, Dual capillary fluid vaporizing device.
  30. Nichols, Walter A.; Cox, Kenneth A.; Nguyen, Tung Tien, Dual capillary fluid vaporizing device.
  31. Faison, Jr.,Gene G.; Gupta,Rajiv; McRae,Douglas D.; Nichols,Walter A., Fluid vaporizing device having controlled temperature profile heater/capillary tube.
  32. Nichols, Walter A.; Cox, Kenneth A.; McRae, Douglas D.; Nguyen, Tung Tien, Fluid vaporizing device having controlled temperature profile heater/capillary tube.
  33. Igor Gonda, Formulation and devices for monitoring the efficacy of the delivery of aerosols.
  34. Childer,Winthrop D.; Tyvoll,David; Sexton,Douglas A., Medicament dispenser.
  35. Childers,Winthrop D., Medicament dispenser.
  36. Blakley, Daniel Robert; Beeton, Daniel, Metered dose inhaler.
  37. Altobelli, David E.; Beavis, Russell; Gray, Larry B.; Kane, Derek G., Metering system and method for aerosol delivery.
  38. Altobelli,David E.; Beavis,Russell; Gray,Larry B.; Kane,Derek G., Metering system and method for aerosol delivery.
  39. Beavis, Russell H.; Gray, Larry B.; Kane, Derek G., Metering system and method for aerosol delivery.
  40. Beavis, Russell H.; Gray, Larry B.; Kane, Derek G., Metering system and method for fluid delivery.
  41. Byron,Peter R.; Hindle,Michael, Method and apparatus for generating an aerosol.
  42. Hindle, Michael; Byron, Peter R.; Gupta, Rajiv, Method for generating an aerosol with a predetermined and/or substantially monodispersed particle size distribution.
  43. Gonda,Igor; Rubsamen,Reid M.; Farr,Stephen J., Method for treating diabetes mellitus in a patient.
  44. Gonda,Igor; Rubsamen,Reid M.; Farr,Stephen J., Method of treating diabetes mellitus in a patient.
  45. Beavis, Russell H.; Gray, Larry B.; Kane, Derek G., Method to deliver medication.
  46. Wensley, Martin; Hufford, Michael; Williams, Jeffrey; Lloyd, Peter, Methods and devices for compound delivery.
  47. Hindle, Michael; Byron, Peter R.; Hong, John N., Mouthpiece entrainment airflow control for aerosol generators.
  48. Heinonen, Erkki, Nebulizer apparatus.
  49. Siegel, Sheryl E., Pharmaceutical identification.
  50. Siegel, Sheryl E., Pharmaceutical identification.
  51. Sannohe,Shinya; Ishinaga,Hideki; Yoshikawa,Takamasa, Projection display device.
  52. Gray,Larry B.; Lanigan,Richard J., System and method for aerosol delivery.
  53. Beavis,Russell; Gray,Larry B., System and method for improved volume measurement.
  54. Beavis,Russell; Gray,Larry B.; Howlett,David J., Valve system and method for aerosol delivery.
  55. Walter A. Nichols, Vapor driven aerosol generator and method of use thereof.
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