Supplemented and unsupplemented tissue sealants, methods of their production and use
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-035/14
A61K-031/74
A61F-002/28
출원번호
US-0474084
(1995-06-07)
발명자
/ 주소
MacPhee Martin James
Drohan William Nash
Lasa
Jr. Carlos I.,PHX
Liau Gene
Haudenschild Christian
출원인 / 주소
The American National Red Cross
대리인 / 주소
Sterne, Kessler, Goldstein & Fox P.L.L.C.
인용정보
피인용 횟수 :
277인용 특허 :
53
초록▼
This invention provides methods for the localized delivery of supplemented tissue sealants, wherein the supplemented tissue sealants comprise at least one composition which is selected from one or more antibodies, analgesics, anticoagulants, anti-inflammatory compounds, antimicrobial compositions, a
This invention provides methods for the localized delivery of supplemented tissue sealants, wherein the supplemented tissue sealants comprise at least one composition which is selected from one or more antibodies, analgesics, anticoagulants, anti-inflammatory compounds, antimicrobial compositions, antiproliferatives, cytokines, cytotoxins, drugs, growth factors, interferons, hormones, lipids, demineralized bone or bone morphogenetic proteins, cartilage inducing factors, oligonucleotides polymers, polysaccharides, polypeptides, protease inhibitors, vasoconstrictors or vasodilators, vitamins, minerals, stabilizers and the like. Further provided are methods of using the site-specific supplemented tissue sealants, including preparation of a biomaterial.
대표청구항▼
[What is claimed is:] [1.](a) preparing a biocompatible, supplemented tissue sealant composition comprising:(i) at least one supplement selected from the group consisting of a cytotoxin or cell proliferation inhibiting compound, an osteogenic compound, an osteoconductive compound, a cartilage induci
[What is claimed is:] [1.](a) preparing a biocompatible, supplemented tissue sealant composition comprising:(i) at least one supplement selected from the group consisting of a cytotoxin or cell proliferation inhibiting compound, an osteogenic compound, an osteoconductive compound, a cartilage inducing compound, an oligonucleotide or polynucleotide, a compound that inhibits the differentiation of cells involved in the formation or metabolism of bone, a compound that induces the differentiation of cells involved in the formation or metabolism of bone, and a compound that prevents resorption of bone, in an amount which promotes generation or regeneration of bone and/or cartilage; and(ii) fibrinogen, or a derivative or metabolite thereof selected from the group consisting of fibrin I and fibrin II, in an amount which forms a fibrin matrix in the presence of thrombin and Ca.sup.++ and water; and(b) applying said composition of step (a) to a site in need of newly formed bone and/or cartilage under conditions which induce formation of a fibrin matrix at a concentration which provides sustained delivery of an amount of said supplement effective to promote the generation or regeneration of bone and/or cartilage,wherein said amount of said supplement is greater than the amount which is soluble in said fibrin matrix; andwherein said fibrin matrix provides a scaffold that determines the shape and location of said newly formed bone and/or cartilage; andfurther wherein said sustained delivery is for a period greater than the period obtained according to simple diffusion kinetics. [2.](a) preparing a biocompatible, supplemented tissue sealant composition comprising:(i) at least one growth factor supplement in an amount which promotes generation or regeneration of bone and/or cartilage; and(ii) fibrinogen, or a derivative or metabolite thereof selected from the group consisting of fibrin I and fibrin II, in an amount which forms a fibrin matrix in the presence of thrombin and Ca.sup.++ and water; and(b) applying said composition of step (a) to a site in need of newly formed bone and/or cartilage under conditions which induce formation of a fibrin matrix at a concentration which provides sustained delivery of an amount of said growth factor supplement effective to promote the generation or regeneration of bone and/or cartilage;wherein said fibrin matrix provides a scaffold that determines the shape and location of said newly formed bone and/or cartilage; andfurther wherein said sustained delivery is for a period greater than the period obtained according to simple diffusion kinetics. [3.](a) preparing a biocompatible, supplemented tissue sealant composition comprising:(i) at least one supplement selected from the group consisting of an osteogenic protein, an osteoconductive protein, a cartilage inducing protein, a polypeptide, a hormone, a cytokine, a cytotoxin or cell proliferation inhibiting protein, a protein that inhibits the differentiation of cells involved in the formation or metabolism of bone, a protein that induces the differentiation of cells involved in the formation or metabolism of bone, and a protein that prevents resorption of bone, in an amount which promotes generation or regeneration of bone and/or cartilage; and(ii) fibrinogen, or a derivative or metabolite thereof selected from the group consisting of fibrin I and fibrin II, in an amount which forms a fibrin matrix in the presence of thrombin and Ca.sup.++ and water; and(b) applying said composition of step (a) to a site in need of newly formed bone and/or cartilage under conditions which induce formation of a fibrin matrix at a concentration which provides sustained delivery of an amount of said supplement effective to promote the generation or regeneration of bone and/or cartilage;wherein said fibrin matrix provides a scaffold that determines the shape and location of said newly formed bone and/or cartilage; andfurther wherein said sustained delivery is for a period greater than the period obtained according to simple diffusion kinetics.
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