초록 ▼

A method of enhancing injury-induced revascularization of a tissue as treatment of a disease, such as coronary artery disease, is described. The method involves (i) creating injury in a tissue (e.g., muscle, such as cardiac muscle) by, for example, use of a laser, an ultrasonic device, or a Thermal

A method of enhancing injury-induced revascularization of a tissue as treatment of a disease, such as coronary artery disease, is described. The method involves (i) creating injury in a tissue (e.g., muscle, such as cardiac muscle) by, for example, use of a laser, an ultrasonic device, or a Thermal probe, and (ii) injecting into the tissue a revascularization-promoting molecule or a nucleic acid molecule encoding a revascularization-promoting molecules Also described is an apparatus that can be used to practice this method.

대표청구항 ▼

[What is claimed is:] [1.]i) creating a track to tissue injury in said tissue, andii) injecting into said tissue a revascularization-promoting molecule or a nucleic acid molecule encoding a revascularization-promoting molecule, wherein the track of the injection is in a predetermined direction relat

[What is claimed is:] [1.]i) creating a track to tissue injury in said tissue, andii) injecting into said tissue a revascularization-promoting molecule or a nucleic acid molecule encoding a revascularization-promoting molecule, wherein the track of the injection is in a predetermined direction relative to but not within, said tack of tissue injury,said method resulting in improvement of a condition of said disease to a greater degree than results from injury-induced revascularization treatment alone.