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Genetic induction of anti-viral immune response and genetic vaccine for filovirus 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-039/12
  • A61K-048/00
  • A61K-009/14
  • C12N-015/87
출원번호 US-0760615 (1996-12-04)
발명자 / 주소
  • Haynes Joel R.
  • Schmaljohn Connie S.
  • Fuller Deborah L.
  • Schmaljohn Alan
  • Jahrling Peter B.
출원인 / 주소
  • PowerJect Vaccines Inc.
대리인 / 주소
    McCracken
인용정보 피인용 횟수 : 25  인용 특허 : 5

초록

An approach to genetic vaccine methodology is described. A genetic construction encoding antigenic determinants of a filovirus is transfected into cells of the vaccinated individuals using a particle acceleration protocol so as to express the viral antigens in healthy cells to produce an immune resp

대표청구항

[We claim:] [1.](a) providing a genetic construction comprising a promoter operative in cells of the mammal and a coding region for a determinant of the glycoprotein, the genetic construction not comprising sequences necessary for replication of the virus;(b) coating copies of the genetic constructi

이 특허에 인용된 특허 (5)

  1. McCabe Dennis E. (Middleton WI) Martinell Brian J. (Madison WI), Apparatus for genetic transformation.
  2. McCabe Dennis E. (Middleton WI), Gas driven gene delivery instrument.
  3. Felgner Philip L. (Rancho Santa Fe CA) Wolff Jon A. (Madison WI) Rhodes Gary H. (Leucadia CA) Malone Robert W. (Chicago IL) Carson Dennis A. (Del Mar CA), Induction of a protective immune response in a mammal by injecting a DNA sequence.
  4. Sanford John C. (Geneva NY) Wolf Edward D. (Ithaca NY) Allen Nelson K. (Newfield NY), Method for transporting substances into living cells and tissues and apparatus therefor.
  5. Christou Paul (Madison WI) McCabe Dennis (Middleton WI) Swain William F. (Madison WI) Barton Kenneth A. (Middleton WI), Particle-mediated transformation of soybean plants and lines.

이 특허를 인용한 특허 (25)

  1. Punnonen,Juha; Wright,Anne; Semyonov,Andrey, Chimeric promoters.
  2. Li, Na; Wang, Jie; Patten, Christopher J., Consumable cryopreserved cells transiently overexpressing gene(s) encoding drug transporter protein(s).
  3. Li, Na; Wang, Jie; Patten, Christopher J., Consumable cryopreserved cells transiently overexpressing gene(s) encoding drug transporter protein(s).
  4. Li, Na; Wang, Jie; Patten, Christopher J., Consumable cryopreserved cells transiently overexpressing gene(s) encoding drug transporter protein(s) and/or drug metabolizing enzyme(s).
  5. Li, Na; Wang, Jie; Patten, Christopher J., Consumable cryopreserved cells transiently overexpressing gene(s) encoding drug transporter protein(s) and/or drug metabolizing enzyme(s).
  6. Nabel, Gary J.; Yang, Zhi yong; Sullivan, Nancy; Sanchez, Anthony, Development of a preventive vaccine for filovirus infection in primates.
  7. Nabel, Gary J.; Yang, Zhi-yong; Sullivan, Nancy; Sanchez, Anthony, Development of a preventive vaccine for filovirus infection in primates.
  8. Nabel, Gary J.; Yang, Zhi-yong; Sullivan, Nancy; Sanchez, Anthony, Development of a preventive vaccine for filovirus infection in primates.
  9. Nabel, Gary J.; Yang, Zhi-yong; Sullivan, Nancy; Sanchez, Anthony, Development of a preventive vaccine for filovirus infection in primates.
  10. Nabel,Gary J.; Yang,Zhi yong, Development of a preventive vaccine for filovirus infection in primates.
  11. Orton, Matthew J.; Mastromattei, Robert; O'Connell, Robert; Schmidt, Richard C.; Reitz, Graham, Electromagnetically actuated multi-leaf collimator.
  12. Hevey, Michael C.; Negley, Diane L.; Pushko, Peter; Smith, Jonathan F.; Schmaljohn, Alan L., Marburg virus vaccines.
  13. Lu, Weiguo; Ruchala, Kenneth J.; Olivera, Gustavo H.; Schnarr, Eric; Kapatoes, Jeffrey M.; Mackie, Thomas R.; Reckwerdt, Paul J., Method and system for adapting a radiation therapy treatment plan based on a biological model.
  14. Ruchala, Kenneth J.; Olivera, Gustavo H.; Lu, Weiguo; Schnarr, Eric; Haimerl, Jason; Mackie, Thomas R.; Kapatoes, Jeffrey M., Method and system for evaluating delivered dose.
  15. Fordyce, II, Gerald D.; Ruchala, Kenneth J.; Schnarr, Eric; Chen, Yu; Reitz, Graham T.; Finley, Scott; O'Connell, Rob; Orton, Matthew, Method and system for evaluating quality assurance criteria in delivery of a treatment plan.
  16. Lu, Weiguo; Olivera, Gustavo H.; Kapatoes, Jeffrey M.; Ruchala, Kenneth J.; Schnarr, Eric; Hughes, John H.; Mackie, Thomas R.; Reckwerdt, Paul J., Method and system for evaluating quality assurance criteria in delivery of a treatment plan.
  17. Schnarr, Eric; Ruchala, Kenneth J.; Olivera, Gustavo H.; Lu, Weiguo; Kapatoes, Jeffrey M.; Haimerl, Jason; Hughes, John H.; Mackie, Thomas R., Method and system for processing data relating to a radiation therapy treatment plan.
  18. Olivera, Gustavo H.; Ruchala, Kenneth J.; Schnarr, Eric; Kapatoes, Jeffrey M.; Lu, Weiguo; Haimerl, Jason; Hughes, John H.; Mackie, Thomas R., Method of and system for predicting dose delivery.
  19. Lu, Weiguo; Olivera, Gustavo H.; Ruchala, Kenneth J.; Schnarr, Eric, Method of placing constraints on a deformation map and system for implementing same.
  20. Olivera, Gustavo H.; Mackie, Thomas R.; Ruchala, Kenneth J.; Reckwerdt, Paul J.; Hughes, John H.; Kapatoes, Jeffrey M.; Schnarr, Eric; Lu, Weiguo; Schloesser, Eric; Fordyce, II, Gerald D.; Holzmann, Tim, Radiation therapy imaging and delivery utilizing coordinated motion of gantry and couch.
  21. Ruchala, Kenneth J.; Olivera, Gustavo H.; Lu, Weiguo; Schnarr, Eric; Hughes, John H.; Kapatoes, Jeffrey M.; Mackie, Thomas R.; Reckwerdt, Paul J., System and method of delivering radiation therapy to a moving region of interest.
  22. Lu, Weiguo; Ruchala, Kenneth J.; Chen, Mingli; Chen, Quan; Olivera, Gustavo H., System and method of detecting a breathing phase of a patient receiving radiation therapy.
  23. Ruchala, Kenneth J.; Olivera, Gustavo H.; Schnarr, Eric; Lu, Weiguo; Mackie, Thomas R., System and method of evaluating dose delivered by a radiation therapy system.
  24. Kapatoes, Jeffrey M.; Olivera, Gustavo H.; Schnarr, Eric; Lu, Weiguo; Ruchala, Kenneth J.; Reckwerdt, Paul J.; Hughes, John H.; Mackie, Thomas R., System and method of generating contour structures using a dose volume histogram.
  25. Olivera, Gustavo H.; Mackie, Thomas R.; Kapatoes, Jeffrey M.; Hughes, John H.; Ruchala, Kenneth J.; Reckwerdt, Paul J., System and method of treating a patient with radiation therapy.
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