초록

Methods are provided for identifying nucleic acids. Methods of the invention are useful for identifying and analyzing nucleic acids, especially variants of single nucleotide polymorphisms, that are indicative of disease or the predisposition for disease.

대표청구항 ▼

[What is claimed is:] [1.](a) determining a number of a genomic polymorphic variant, the presence of which is a diagnostic disease marker, at a single base polymorphic locus in a genomic DNA sample obtained from the patient;(b) applying to said number a predetermined statistical relationship, said s

[What is claimed is:] [1.](a) determining a number of a genomic polymorphic variant, the presence of which is a diagnostic disease marker, at a single base polymorphic locus in a genomic DNA sample obtained from the patient;(b) applying to said number a predetermined statistical relationship, said statistical relationship correlating numbers of said genomic polymorphic variants in a sample comprising pooled genomic DNA obtained from members of a population of having said disease, with the clinical severity of said disease; and(c) determining the clinical severity of said disease of the patient.