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Specific antibodies and antibody fragments 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-039/395
  • C07K-016/28
  • C12N-005/12
출원번호 US-0040953 (1998-03-18)
발명자 / 주소
  • Kuchroo Vijay K.
  • Greenfield Edward A.
출원인 / 주소
  • Brigham and Women's Hospital, Inc.
대리인 / 주소
    Wolf, Greenfield & Sacks, P.C.
인용정보 피인용 횟수 : 37  인용 특허 : 9

초록 ▼

The present invention relates to methods and products for immunotherapy resulting in the stimulation of T-cell proliferation. The products of the invention are peptides that bind to CTLA-4 and co-stimulate the proliferation of T-cells by inhibiting the binding of B7 to CTLA-4. Pharmaceutical composi

대표청구항 ▼

[We claim:] [1.]wherein the isolated CTLA-4 specific antibody or antibody fragment comprises a CDR selected from the group consisting of a CDR from monoclonal antibody.sub.A3.4H2 produced by hybridoma A3.4H2 deposited under ATCC Accession No. HB-12319 and a CDR from monoclonal antibody.sub.A3.6B10 p

이 특허에 인용된 특허 (9)

  1. Capon Daniel J. (San Mateo CA) Gregory Timothy J. (Hillsborough CA), Adhesion variants.
    상세보기
  2. Allison James Patrick ; Leach Dana R. ; Krummel Matthew F., Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling.
    상세보기
  3. Linsley Peter S. (Seattle WA) Ledbetter Jeffrey A. (Seattle WA) Damle Nitin K. (Renton WA) Brady William (Bothell WA), Chimeric CTLA4 receptor and methods for its use.
    상세보기
  4. Capon Daniel J. (San Mateo CA) Lasky Laurence A. (Sausalito CA), Expression vector encoding hybrid immunoglobulins.
    상세보기
  5. Dalie Barbara (Berkeley Heights NJ) Miller Kenneth (Cranford NJ) Murgolo Nicholas (Millington NJ) Tindall Stephen (Madison NJ), Humanized monoclonal antibodies against human interleukin-4.
    상세보기
  6. Tykocinski Mark L. (Shaker Heights OH) Kaplan David R. (Cleveland Heights OH), Method of reducing cellular immune response involving T-cells using CD8-bearing antigen presenting cells.
    상세보기
  7. Lillehoj Hyun S. (W. Friendship MD), Monoclonal antibodies against chicken T-lymphocytes.
    상세보기
  8. Maino Vernon C. (Los Altos CA) Janszen Marina E. (Los Altos CA), Monoclonal antibodies and their use in a method for monitoring subsets of activated T cells.
    상세보기
  9. Lederman Seth (New York NY) Chess Leonard (Scarsdale NY) Yellin Michael J. (Riverdale NY), Murine monoclonal antibody (5c8) recognizes a human glycoprotein on the surface of T-lymphocytes, compositions containin.
    상세보기

이 특허를 인용한 특허 (37)

  1. van Dijk, Marc; Mundt, Cornelia Anne; Ritter, Gerd; Schaer, David; Wolchok, Jedd David; Merghoub, Taha; Savitsky, David Adam; Wilson, Nicholas Stuart, Anti-CTLA-4 antibodies and methods of use thereof.
    상세보기
  2. Seibert, Volker; Léger, Olivier; Van Dijk, Marc; Merghoub, Taha; Schaer, David; Ritter, Gerd; Tsuji, Takemasa, Anti-GITR antibodies and methods of use thereof.
    상세보기
  3. Carreno,Beatriz M.; Wood,Clive; Turner,Katherine; Collins,Mary; Gray,Gary S.; Morris,Donna; O'Hara,Denise; Hinton,Paul R.; Tsurushita,Naoya, Antibodies against CTLA4.
    상세보기
  4. Schebye, Xiao Min; Selby, Mark J.; Han, Michelle Minhua; Bee, Christine; Deng, Andy X.; Chuntharapai, Anan; Devaux, Brigitte; Li, Huiming; Sheppard, Paul O.; Korman, Alan J.; Ardourel, Daniel F.; Deyanova, Ekaterina; Huang, Richard; Chen, Guodong; Kuhne, Michelle; Troung, Hong-An, Antibodies against TIM3 and uses thereof.
    상세보기
  5. Schebye, Xiao Min; Selby, Mark J.; Han, Michelle Minhua; Bee, Christine; Deng, Andy X.; Chuntharapai, Anan; Devaux, Brigitte; Li, Huiming; Sheppard, Paul O.; Korman, Alan J.; Ardourel, Daniel F.; Deyanova, Ekaterina; Huang, Richard; Chen, Guodong; Kuhne, Michelle; Troung, Hong-An, Antibodies against TIM3 and uses thereof.
    상세보기
  6. Bermudes, David Gordon, Bacteria carrying bacteriophage and protease inhibitors for the treatment of disorders and methods of treatment.
    상세보기
  7. Nichol, Geoffrey M.; Lowy, Israel, CTLA-4 antibody dosage escalation regimens.
    상세보기
  8. Nichol, Geoffrey M.; Lowy, Israel, CTLA-4 antibody dosage escalation regimens.
    상세보기
  9. Jure-Kunkel, Maria, Combination of CD137 antibody and CTLA-4 antibody for the treatment of proliferative diseases.
    상세보기
  10. Jure-Kunkel, Maria; Lee, Francis Y., Combination of anti-CTLA4 antibody with dasatinib for the treatment of proliferative diseases.
    상세보기
  11. Jure-Kunkel, Maria, Combination of anti-CTLA4 antibody with diverse therapeutic regimens for the synergistic treatment of proliferative diseases.
    상세보기
  12. Jure-Kunkel, Maria, Combination of anti-CTLA4 antibody with diverse therapeutic regimens for the synergistic treatment of proliferative diseases.
    상세보기
  13. Korman,Alan J.; Halk,Edward L.; Lonberg,Nils; Deo,Yashwant M.; Keler,Tibor P., Human CTLA-4 antibodies.
    상세보기
  14. Korman, Alan J.; Halk, Edward L.; Lonberg, Nils; Deo, Yashwant M.; Keler, Tibor P., Human CTLA-4 antibodies and their uses.
    상세보기
  15. Korman, Alan J.; Halk, Edward L.; Lonberg, Nils; Deo, Yashwant M.; Keler, Tibor P., Human CTLA-4 antibodies and their uses.
    상세보기
  16. Korman, Alan J.; Halk, Edward L.; Lonberg, Nils; Deo, Yashwant M.; Keler, Tibor P., Human CTLA-4 antibodies and their uses.
    상세보기
  17. Korman, Alan J.; Halk, Edward L.; Lonberg, Nils; Deo, Yashwant M.; Keler, Tibor P., Human CTLA-4 antibodies and their uses.
    상세보기
  18. Hanson, Douglas Charles; Neveu, Mark Joseph; Mueller, Eileen Elliott; Hanke, Jeffrey Herbert; Gilman, Steven Christopher; Davis, C. Geoffrey; Corvalan, Jose Ramon, Human monoclonal antibodies to CTLA-4.
    상세보기
  19. Hanson, Douglas Charles; Neveu, Mark Joseph; Mueller, Eileen Elliott; Hanke, Jeffrey Herbert; Gilman, Steven Christopher; Davis, C. Geoffrey; Corvalan, Jose Ramon, Human monoclonal antibodies to CTLA-4.
    상세보기
  20. Hanson, Douglas Charles; Neveu, Mark Joseph; Mueller, Eileen Elliott; Hanke, Jeffrey Herbert; Gilman, Steven Christopher; Davis, C. Geoffrey; Corvalan, Jose Ramon, Human monoclonal antibodies to CTLA-4.
    상세보기
  21. Hanson, Douglas Charles; Neveu, Mark Joseph; Mueller, Eileen Elliott; Hanke, Jeffrey Herbert; Gilman, Steven Christopher; Davis, C. Geoffrey; Corvalan, Jose Ramon, Human monoclonal antibodies to CTLA-4.
    상세보기
  22. Hanson, Douglas Charles; Neveu, Mark Joseph; Mueller, Eileen Elliott; Hanke, Jeffrey Herbert; Gilman, Steven Christopher; Davis, C. Geoffrey; Corvalan, Jose Ramon, Human monoclonal antibodies to CTLA-4.
    상세보기
  23. Hanson, Douglas Charles; Neveu, Mark Joseph; Mueller, Eileen Elliott; Hanke, Jeffrey Herbert; Gilman, Steven Christopher; Davis, C. Geoffrey; Corvalan, Jose Ramon, Human monoclonal antibodies to CTLA-4.
    상세보기
  24. Bermudes, David Gordon, Immunization and/or treatment of parasites and infectious agents by live bacteria.
    상세보기
  25. Bermudes, David Gordon, Live bacterial vectors for prophylaxis or treatment.
    상세보기
  26. Chin, Li-Te; Hsu, Shu-Ching, Method of isolating regulatory T cells from human samples.
    상세보기
  27. Hanson,Douglas Charles; Neveu,Mark Joseph; Mueller,Eileen Elliott; Hanke,Jeffrey Herbert; Gilman,Steven Christopher; Davis,C. Geoffrey; Corvalan,Jose Ramon, Methods and host cells for producing human monoclonal antibodies to CTLA-4.
    상세보기
  28. Hanson,Douglas Charles; Neveu,Mark Joseph; Mueller,Eileen Elliott; Hanke,Jeffrey Herbert; Gilman,Steven Christopher; Davis,C. Geoffrey; Corvalan,Jose Ramon, Methods for expressing and recovering human monoclonal antibodies to CTLA-4.
    상세보기
  29. Hanson, Douglas Charles; Neveu, Mark Joseph; Mueller, Eileen Elliott; Hanke, Jeffrey Herbert; Gilman, Steven Christopher; Davis, C. Geoffrey; Corvalan, Jose Ramon, Methods of treating cancer with human monoclonal antibodies to CTLA-4.
    상세보기
  30. Davis, Thomas Andrew; Keler, Tibor P.; Graziano, Robert F.; Korman, Alan J., Methods of treatment using CTLA-4 antibodies.
    상세보기
  31. Davis,Thomas Andrew; Keler,Tibor P.; Graziano,Robert F.; Korman,Alan J., Methods of treatment using CTLA-4 antibodies.
    상세보기
  32. Hanson,Douglas C; Neveu,Mark J; Mueller,Eileen E; Hanke,Jeffrey H; Gilman,Steven C; Davis,C. Geoffrey; Corvalan,Jose R, Nucleic acids encoding human monoclonal antibodies to CTLA-4.
    상세보기
  33. Bermudes, David Gordon, Protease inhibitor: protease sensitive expression system and method improving the therapeutic activity and specificity of proteins and phage and phagemids delivered by bacteria.
    상세보기
  34. Bermudes, David Gordon, Protease inhibitor: protease sensitive expression system composition and methods improving the therapeutic activity and specificity of proteins delivered by bacteria.
    상세보기
  35. Bermudes, David Gordon, Protease inhibitor: protease sensitivity expression system composition and methods improving the therapeutic activity and specificity of proteins delivered by bacteria.
    상세보기
  36. Fischkoff, Steven; Lowy, Israel; Yellin, Michael; Yang, James Chung Yin, TNF-alpha blocker treatment for enterocolitis associated with immunostimulatory therapeutic antibody therapy.
    상세보기
  37. Bermudes, David Gordon; Quintero, David, Topical and orally administered protease inhibitors and bacterial vectors for the treatment of disorders and methods of treatment.
    상세보기

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