Antimicrobial agents uses and compositions related thereto
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-031/4709
C07D-401/04
출원번호
US-0045051
(1998-03-19)
발명자
/ 주소
Cuny Gregory D.
Hauske James R.
Heefner Donald L.
Hoemann Michael Z.
Kumaravel Gnanasambandam
Melikian-Badalian Anita
Rossi Richard F.
출원인 / 주소
Sepracor, Inc.
대리인 / 주소
Vincent
인용정보
피인용 횟수 :
21인용 특허 :
12
초록
The present invention provides methods and pharmaceutical preparations that inhibit the growth of bacterial microorganisms. Additionally, the present invention provides methods and pharmaceutical preparations that kill bacterial microorganisms.
대표청구항▼
[We claim:] [1.] reinA and B represent fused benzo rings;X represents N;Y represents NR;R, R.sub.1, R.sub.2, and R.sub.3, for each occurrence, independently represent hydrogen, halogen, alkyl, alkenyl, alkynyl, hydroxyl, alkoxyl, silyloxy, amino, nitro, sulfhydryl, alkylthio, imine, amide, phosphory
[We claim:] [1.] reinA and B represent fused benzo rings;X represents N;Y represents NR;R, R.sub.1, R.sub.2, and R.sub.3, for each occurrence, independently represent hydrogen, halogen, alkyl, alkenyl, alkynyl, hydroxyl, alkoxyl, silyloxy, amino, nitro, sulfhydryl, alkylthio, imine, amide, phosphoryl, phosphonate, phosphine, carbonyl, carboxyl, carboxamide, anhydride, silyl, thioalkyl, alkylsulfonyl, arylsulfonyl, selenoalkyl, ketone, aldehyde, ester, heteroalkyl, nitrile, guanidine, amidine, acetal, ketal, amine oxide, aryl, heteroaryl, azide, aziridine, carbamate, epoxide, hydroxamic acid, imide, oxime, sulfonamide, thioamide, thiocarbamate, urea, thiourea, or --(CH.sub.2).sub.m --R.sub.80 ;R.sub.4, for each occurrence, independently represents halogen, alkyl, alkenyl, alkynyl, hydroxyl, alkoxyl, silyloxy, amino, nitro, sulfhydryl, alkylthio, imine, amide, phosphoryl, phosphonate, phosphine, carbonyl, carboxyl, carboxamide, anhydride, silyl, thioalkyl, alkylsulfonyl, arylsulfonyl, selenoalkyl, ketone, aldehyde, ester, heteroalkyl, nitrile, guanidine, amidine, acetal, ketal, amine oxide, aryl, heteroaryl, azide, aziridine, carbamate, epoxide, hydroxamic acid, imide, oxime, sulfonamide, thioamide, thiocarbamate, urea, thiourea, or --(CH.sub.2).sub.m --R.sub.80 ;R.sub.5, for each occurrence, independently represents halogen, alkyl, alkenyl, alkynyl, hydroxyl, alkoxyl, silyloxy, amino, sulfhydryl, alkylthio, imine, amide, phosphoryl, phosphonate, phosphine, carbonyl, carboxyl, carboxamide, anhydride, silyl, thioalkyl, alkylsulfonyl, arylsulfonyl, selenoalkyl, ketone, aldehyde, ester, heteroalkyl, nitrile, guanidine, amidine, acetal, ketal, amine oxide, azide, aziridine, carbamate, epoxide, hydroxamic acid, imide, oxime, sulfonamide, thioamide, thiocarbamate, urea, thiourea, or --(CH.sub.2).sub.n --R.sub.80 ;A may be unsubstituted or substituted with R.sub.4 any number of times up to the limitations imposed by stability and the rules of valence;B is substituted with at least one instance of R.sub.5, but in no case more than the maximum number of instances of R.sub.5 allowed by the limitations imposed by stability and the rules of valence;R.sub.80 represents an unsubstituted or substituted aryl, a cycloalkyl, a cycloalkenyl, a heterocycle, or a polycycle;n is an integer in the range 1 to 8 inclusive; andm is an integer in the range 0 to 8 inclusive.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (12)
Sutherland Leslie H. (Dallas TX) Sloboda Adolph E. (Rockland NY) Child Ralph G. (Rockland NY) Poletto John F. (Bergen NJ) Powell Dennis W. (Rockland NY), 2-Phenyl-4-quinoline carboxylic acids.
Batt Douglas G. (Wilmington DE) Petraitis Joseph J. (Glenmoore PA) Sherk Susan R. (Wilmington DE), 2-carbocyclic and 2-heterocyclic quinoline-4-carboxylic acids and salts thereof useful as immunosuppressive agents.
Batt Douglas G. (Wilmington DE) Petraitis Joseph J. (Glenmoore PA) Sherk Susan R. (Wilmington DE), 2-carbocyclic and 2-heterocyclic quinoline-4-carboxylic acids and salts thereof useful as immunosuppressive agents.
Ackerman Neil R. (Greenville DE) Harris Richard R. (Wilmington DE) Loveless Scott E. (Newark DE) Neubauer Russell H. (West Chester PA), 4-Quinoline carboxylic acid derivatives useful as immunosuppressive agents.
Ackerman Neil R. (Greenville DE) Harris Richard R. (Wilmington DE) Loveless Scott E. (Newark DE) Neubauer Russel H. (West Chester PA), 4-quinoline carboxylic acid derivatives useful for treating skin and muco-epithelial diseases.
Myers Michael R. ; Spada Alfred P. ; Maguire Martin P. ; Persons Paul E., Aryl and heteroaryl quinazoline compounds which inhibit EGF and/or PDGF receptor tyrosine kinase.
Spada Alfred P. (Lansdale PA) Myers Michael R. (Reading PA) Maguire Martin P. (Mont Clare PA) Persons Paul E. (King of Prussia PA), Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase.
Spada Alfred P. ; Myers Michael R. ; Maguire Martin P. ; Persons Paul E., Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase.
Still W. Clark (Clinton NY) Wigler Michael H. (Lloyd Harbor NY) Ohlmeyer Michael H. J. (Plainsboro NJ) Dillard Lawrence W. (Plainsboro NJ) Reader John C. (Princeton NJ), Complex combinatorial chemical libraries encoded with tags.
Friedhoff, Lawrence Tim; Ramaswamy, Shankar; Wen, Yandong, Diaryl and arylheteroaryl urea derivatives as modulators of the 5-HT2A serotonin receptor useful for the prophylaxis and treatment of REM sleep behavior disorder.
Teegarden, Bradley; Jayakumar, Honnappa; Li, Hongmei; Strah-Pleynet, Sonja; Dosa, Peter I., Diaryl and arylheteroaryl urea derivatives as modulators of the 5-HT2A serotonin receptor useful for the prophylaxis and treatment of disorders related thereto.
Friedhoff, Lawrence Tim; Ramaswamy, Shankar; Wen, Yandong, Diaryl and arylheteroaryl urea derivatives as modulators of the 5-HT2A serotonin receptor useful for the prophylaxis and treatment of hallucinations associated with a neurodegenerative disease.
Wooley, Richard E.; Ritchie, Branson W.; Kemp, Douglas T.; Capomacchia, Anthony C.; Burnley, Victoria V., Methods and compositions for promoting wound healing.
Wooley, Richard E.; Ritchie, Branson W.; Kemp, Douglas T.; Capomacchia, Anthony C.; Burnley, Victoria V., Methods and compositions for promoting wound healing.
Carlos, Marlon; Dong, Weitong; Macias, Mark; Sato, Suzanne Michiko; Selvey, Lee Alani, Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)-urea and crystalline forms related thereto.
Ahmed, Mahmood; Johnson, Christopher Norbert; Jones, Martin C; MacDonald, Gregor James; Moss, Stephen Frederick; Thompson, Mervyn; Wade, Charles Edward; Witty, David R, Quinoline derivatives and their use as 5-HT6 ligands.
Ahmed, Mahmood; Johnson, Christopher Norbert; Jones, Martin C; MacDonald, Gregor James; Moss, Stephen Frederick; Thompson, Mervyn; Wade, Charles Edward; Witty, David R, Quinoline derivatives and their use as 5-HT6 ligands.
Ahmed, Mahmood; Johnson, Christopher Norbert; MacDonald, Gregor James; Moss, Stephen Frederick; Thompson, Mervyn; Witty, David R, Quinoline derivatives and their use as 5-HT6 ligands.
Ahmed, Mahmood; Johnson, Christopher Norbert; Jones, Martin C; MacDonald, Gregor James; Moss, Stephen Frederick; Thompson, Mervyn; Wade, Charles Edward; Witty, David R, Quinoline derivatives and their use as 5-HTligands.
Wang, Yihan; Metcalf, III, Chester A.; Shakespeare, William C.; Sawyer, Tomi K.; Bohacek, Regine; Sundaramoorthi, Rajeswari, Quinolines and uses thereof.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.