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Biodegradable polymer matrices for sustained delivery of local anesthetic agents 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-009/16
출원번호 US-0932550 (1997-09-17)
발명자 / 주소
  • Berde Charles B.
  • Langer Robert S.
출원인 / 주소
  • Children's Medical Center Corporation
대리인 / 주소
    Arnall Golden & Gregory, LLP
인용정보 피인용 횟수 : 34  인용 특허 : 52

초록 ▼

Biodegradable controlled release microspheres for the prolonged administration of a local anesthetic agent, and a method for the manufacture thereof are disclosed. The microspheres are formed of a biodegradable polymer degrading significantly within a month, with at least 50% of the polymer degradin

대표청구항 ▼

[ What is claimed is:] [1.]1. A method for prolonged nerve blockade, local numbness, or pain relief at a site in a patient comprisingadministering at the site a multiparticulate unit dose of a local anesthetic selected from the group consisting of bupivacaine, dibucaine, etidocaine, tetracaine, lido

이 특허에 인용된 특허 (52)

  1. Beck Lee R. (Birmingham AL) Flowers ; Jr. Charles F. (Birmingham AL) Cowsar Donald R. (Birmingham AL) Tanquary Albert C. (Birmingham AL), Active/passive immunization of the internal female reproductive organs.
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  2. Kohn Joachim (Brookline MA) Langer Robert S. (Somerville MA), Biocompatible, bioerodible, hydrophobic, implantable polyimino carbonate article.
    상세보기
  3. Kohn Joachim B. (Highland Park NJ) Langer Robert S. (Somerville MA) Niemi Steven M. (Sudbury MA) Fox James G. (Littleton MA), Biodegradable polymeric drug delivery system with adjuvant activity.
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  4. D\Amore Patricia (Brookline MA) Leong Kam W. (Cambridge MA) Langer Robert S. (Somerville MA), Bioerodible articles useful as implants and prostheses having predictable degradation rates.
    상세보기
  5. D\Amore Patricia (Brookline MA) Leong Kam W. (Cambridge MA) Langer Robert S. (Somerville MA), Bioerodible articles useful as implants and prostheses having predictable degradation rates.
    상세보기
  6. Langer Robert S. (Somerville MA) Rosen Howard (Montara CA), Bioerodible polyanhydrides for controlled drug delivery.
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  7. Langer Robert S. (Somerville MA) Rosen Howard (Montara CA) Linhardt Robert J. (Iowa City IA) Leong Kam (Cambridge MA), Bioerodible polyanhydrides for controlled drug delivery.
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  8. Langer Robert (Somerville MA) Levy Robert J. (Newton MA), Biomaterial implants which resist calcification.
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  9. Loesche Walter J. (1814 Hermitage Ann Arbor MI 48104), Composition for periodontal administration.
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  10. Akao Mutsuo (Kanagawa JPX), Container for photographic film cartridge.
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  11. Baker Richard W. (Menlo Park CA), Controlled release drug delivery system for the periodontal pocket.
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  12. Kronenthal Richard L. (Fair Lawn NJ) Mattei Frank V. (Piscataway NJ) Levy Alan (Bridgewater NJ), Controlled release of pharmacologically active agents from an absorbable biologically compatible putty-like composition.
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  13. Kronenthal Richard L. (Fair Lawn NJ) Mattei Frank V. (Piscataway NJ) Levy Alan J. (Bridgewater NJ), Controlled release of pharmacologically active agents from an absorbable biologically compatible putty-like composition.
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  14. Tsuk Andrew G. (Plattsburgh NY) Martin Frederick H. (West Chazy NY), Dosage form.
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  15. Choi ; Nam Sok ; Heller ; Jorge, Drug delivery devices manufactured from poly(orthoesters) and poly(orthocarbonates).
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  16. Urquhart John (Palo Alto CA) Theeuwes Felix (Los Altos CA), Drug delivery system comprising a reservoir containing a plurality of tiny pills.
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  17. Choi Nam S. (Seoul CA KRX) Heller Jorge (Palo Alto CA), Erodible agent releasing device comprising poly(orthoesters) and poly(orthocarbonates).
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  18. Domb Abraham J. (Brookline MA) Langer Robert S. (Somerville MA), High molecular weight polyanhydride and preparation thereof.
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  19. Zetter Bruce R. (Cambridge MA) Langer Robert S. (Somerville MA), Implantable chemoattractant system.
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  20. Tice Thomas R. (Birmingham AL) Lewis Danny H. (Gardendale AL) Cowsar Donald R. (Birmingham AL) Beck Lee R. (Birmingham AL), Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents.
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  21. Tice, Thomas R.; Lewis, Danny H.; Cowsar, Donald R.; Beck, Lee R., Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents.
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  22. Domb Abraham J. (Baltimore MD) Maniar Manoj (Baltimore MD), Liposphere delivery systems for local anesthetics.
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  23. Domb Abraham J. (Baltimore MD), Lipsopheres for controlled delivery of substances.
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  24. Jernberg Gary R. (99 Navaho Ave. Ste. 102 Mankato MN 56001), Local delivery of chemotherapeutic agents for the treatment of periodontal disease.
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  25. DeFoney George F. (Philadelphia PA) Mayes Donald S. (Sunbury PA) Brenman Henry S. (Cinnaminson NJ), Long-acting articles for oral delivery and process.
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  26. Nagai Tsuneji (Chofu JPX) Machida Yoshiharu (Kawasaki JPX) Suzuki Yoshiki (Hino JPX) Ikura Hiroshi (Hino JPX), Method and preparation for administration to the mucosa of the oral or nasal cavity.
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  27. Nagai Tsuneji (Chofu JPX) Machida Yoshiharu (Kawasaki JPX) Suzuki Yoshiki (Hino JPX) Ikura Hiroshi (Hino JPX), Method and preparation for administration to the mucosa of the oral or nasal cavity.
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  28. Sakamoto Seizaburo (Chestnut Hill MA) Sakamoto Masako (Chestnut Hill MA), Method for inhibiting bone resorption and collagenase release.
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  29. Tice Thomas R. (Birmingham AL) Gilley Richard M. (Birmingham AL) Eldridge John H. (Birmingham AL) Staas Jay K. (Birmingham AL) Hollingshead Melinda G. (Birmingham AL) Shannon William M. (Birmingham A, Method of potentiating an immune response.
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  30. Cohen Edgar C. (4123 Vincennes Pl. New Orleans LA 70125), Microencapsulated astringent hemostatic agents and methods of use.
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  31. Kohn Joachim (Brookline MA) Langer Robert S. (Somerville MA), Non-peptide polyamino acid bioerodible polymers.
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  32. Domb Abraham J. (Baltimore MD) Langer Robert S. (Newton MA) Ron Eyal (Lexington MA) Giannos Steven (Somerville MO) Kothari Rohit (Kansas City MO) Mathiowitz Edith (Brookline MA), One step preparation of poly(amide-anhydride).
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  33. Theeuwes Felix (Los Altos CA), Osmotic therapeutic system for administering medicament.
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  34. Baker Richard W. (Palo Alto CA), Periodontal disease treatment system.
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  35. Tanaka Wataru (Hoya JA) Akito Eiichiro (Omiya JA) Yoshida Koichi (Soka JA) Terada Takashi (Yono JA) Ninomiya Hiroshi (Sayama JA), Pharmaceutical preparation for oral cavity administration.
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  36. Suzuki Yoshiki (Hino JPX) Ikura Hiroshi (Hino JPX) Noguchi Toshihide (Tokyo JPX) Izumizawa Katsunori (Yokohama JPX) Kinoshita ; deceased Shiro (late of Tokyo JPX by Kimiko Kinoshita ; Atsuhiro Kinosh, Pharmaceutical preparation for remedy of periodontal disease and process for production thereof.
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  37. Schmitt ; Edward Emil, Poly(orthoester) co- and homopolymers and poly(orthocarbonate) co- and homopolymers having carbonyloxy functionality.
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  38. Ron Eyal (Lexington MA) Chasin Mark (Englishtown NJ) Turek Tom (Dorchester MA) Langer Robert S. (Newton MA), Polyanhydride bioerodible controlled release implants for administration of stabilized growth hormone.
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  39. Domb Abraham J. (Brookline MA) Langer Robert S. (Somerville MA), Polyanhydrides with improved hydrolytic degradation properties.
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  40. Mathiowitz Edith (Brookline MA) Langer Robert S. (Somerville MA) Warshawsky Abraham (Rehovot MA ILX) Edelman Elazar (Brookline MA), Polymer composite for controlled release or membrane formation.
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  41. Domb Abraham J. (Brookline MA) Langer Robert S. (Somerville MA), Preparation of anhydride copolymers.
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  42. Mathiowitz Edith (Brookline MA) Langer Robert S. (Somerville MA), Preparation of multiwall polymeric microcapsules.
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  43. Cohen Jonathan M. (Elmont NY) Siegel Ronald (Arlington Hts. MA) Langer Robert (Somerville MA), Process for making systems for the controlled release of macromolecules.
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  44. Lapka Galen G. (Belleville IL) Mason Norbert S. (Clayton MO) Thies Curt (Ballwin MO), Process for preparation of microcapsules.
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  45. Okada Hiroaki (Suita JPX) Ogawa Yasuaki (Ibaraki JPX) Yashiki Takatsuka (Takarazuka JPX), Prolonged release microcapsule and its production.
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  46. Schor Joseph M. (Locust Valley NY) Nigalaye Ashok (Elmhurst NY) Gaylord Norman G. (New Providence NJ), Prolonged release therapeutic compositions based on hydroxypropylmethylcellulose.
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  47. Domb Abraham J. (Brookline MA) Langer Robert S. (Somerville MA) Ron Eyal (Waltham MA) Giannos Steven (Somerville MA) Kothari Rohit (Somerville MA) Mathiowitz Edith (Somerville MA), Pure polyanhydride from dicarboxylic acid and coupling agent.
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  48. Choi ; Nam S. ; Heller ; Jorge, Structured orthoester and orthocarbonate drug delivery devices.
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  49. Bawa Rajan (Fairport NY) Deichert William G. (Macedon NY), Sustained-release formulation containing an amino acid polymer with a lower alkyl (C1-C4) po.
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  50. Wheatley Margaret A. (Norristown PA) Langer Robert S. (Somerville MA) Eisen Herman N. (Waban MA), System for controlled release of biologically active compounds.
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  51. Wheatley Margaret A. (Arlington MA) Langer Robert S. (Somerville MA) Eisen Herman N. (Waban MA), System for delayed and pulsed release of biologically active substances.
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  52. Langer Robert S. (Somerville MA) Kost Joseph (Brookline MA), Ultrasonically modulated polymeric devices for delivering compositions.
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이 특허를 인용한 특허 (34)

  1. Ambrose, Catherine G.; Clyburn, Terry A.; Mikos, Antonio G., Antibiotic microspheres for treatment and prevention of osteomyelitis and enhancement of bone regrowth.
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  2. Hobot, Christopher M.; Benz, Michael E.; Hildebrand, Keith R.; Pudil, Bryant J., Baclofen formulation in a polyorthoester carrier.
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  3. Hobot, Christopher M.; Benz, Michael E.; Hildebrand, Keith R.; Pudil, Bryant J., Benzodiazepine formulation in a polyorthoester carrier.
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  4. Hobot, Christopher M.; Benz, Michael E.; Hildebrand, Keith R.; Pudil, Bryant J., Bupivacaine formulation in a polyorthoester carrier.
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  5. Chen, Guohua; Houston, Paul R.; Kleiner, Lothar; Spaltro, John, Catheter injectable depot compositions and uses thereof.
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  6. Smith, Thomas J., Coated particles for sustained-release pharmaceutical administration.
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  7. Bodick, Neil; Blanks, Robert C.; Kumar, Anjali; Clayman, Michael D.; Moran, Mark, Corticosteroids for the treatment of joint pain.
    상세보기
  8. Bodick, Neil; Blanks, Robert C.; Kumar, Anjali; Clayman, Michael D.; Moran, Mark, Corticosteroids for the treatment of joint pain.
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  9. Bodick, Neil; Blanks, Robert C.; Kumar, Anjali; Clayman, Michael D.; Moran, Mark, Corticosteroids for the treatment of joint pain.
    상세보기
  10. Hotchkiss, Robert N; Koski, John A, Drug delivery to a joint.
    상세보기
  11. Chen, Guohua; Houston, Paul R.; Kleiner, Lothar Walter; Spaltro, John J., Injectable depot compositions and uses thereof.
    상세보기
  12. Chen, Guohua; Houston, Paul; Kleiner, Lothar; Wright, Jeremy, Injectable multimodal polymer depot compositions and uses thereof.
    상세보기
  13. Helliwell, James A.; Malone, Amanda M.; Smith, Thomas J.; Baum, Marc M., Injectable sustained release composition and method of using the same for treating inflammation in joints and pain associated therewith.
    상세보기
  14. Lewis, Andrew Lennard; Tang, Yiqing; Fajardo, Maria Victoria Gonzalez, Loading of hydrophobic drugs into hydrophilic polymer delivery systems.
    상세보기
  15. Lewis, Andrew Lennard; Tang, Yiqing; Gonzalez Fajardo, Maria Victoria, Loading of hydrophobic drugs into hydrophilic polymer delivery systems.
    상세보기
  16. Shen, Hui Rong; Gan, Na, Long-acting semi-solid lipid formulations.
    상세보기
  17. Williams, Simon F.; Martin, David P.; Skraly, Frank A., Medical devices and applications of polyhydroxyalkanoate polymers.
    상세보기
  18. Rizk, Said; Martin, David P.; Ho, Kicherl; Williams, Simon F., Medical devices containing oriented films of poly-4-hydroxybutyrate and copolymers.
    상세보기
  19. Martin, David P.; Rizk, Said; Ahuja, Ajay; Williams, Simon F., Method of making a medical textile from polyhydroxyalkanoate fibers.
    상세보기
  20. Rizk, Said, Method of making a polyhydroxyalkanoate filament.
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  21. Sackler, Richard S.; Goldenheim, Paul D.; Chasin, Mark; Burch, Ronald M.; Reder, Robert F.; Tigner, Joseph, Methods for providing safe local anesthesia.
    상세보기
  22. Ganatra, Amit; Felix, Fabio; Shah, Bhavin; Bernasconi, Matthew; Rizk, Said; Martin, David P.; Williams, Simon F., Methods of orienting multifilament yarn and monofilaments of poly-4-hydroxybutyrate and copolymers thereof.
    상세보기
  23. Ganatra, Amit; Felix, Fabio; Shah, Bhavin; Bernasconi, Matthew; Rizk, Said; Martin, David P.; Williams, Simon F., Methods of orienting multifilament yarn and monofilaments of poly-4-hydroxybutyrate and copolymers thereof.
    상세보기
  24. Costantino, Henry R.; Hotz, Joyce M.; Dasch, James R.; Riley, M. Gary I.; Burke, Paul A.; Steitz-Abadi, Susan A.; Zale, Stephen E., Microencapsulation and sustained release of biologically active polypeptides.
    상세보기
  25. Alkatout, Julie A.; Benz, Michael Eric; Sparer, Randall V., Poly(orthoester) polymers, and methods of making and using same.
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  26. Alkatout, Julie A.; Benz, Michael Eric; Sparer, Randall V., Poly(orthoester) polymers, and methods of making and using same.
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  27. Martin, David P.; Rizk, Said; Ahuja, Ajay; Williams, Simon F., Polyhydroxyalkanoate medical textiles and fibers.
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  28. Martin, David P.; Rizk, Said; Ahuja, Ajay; Williams, Simon F., Polyhydroxyalkanoate medical textiles and fibers.
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  29. Martin, David P.; Rizk, Said; Ahuja, Ajay; Williams, Simon F., Polyhydroxyalkanoate medical textiles and fibers.
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  30. Martin, David P.; Rizk, Said; Ahuja, Ajay; Williams, Simon F., Polyhydroxyalkanoate medical textiles and fibers.
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  31. Martin, David P.; Rizk, Said; Ahuja, Ajay; Williams, Simon F., Process of making polyhydroxyalkanoate medical textiles.
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  32. Tunc, Deger C.; Ranawat, Chitranjan S.; Ranawat, Amar S., Prosthesis with sustained release analgesic.
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  33. Chen, Guohua; Priebe, David, Short duration depot formulations.
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  34. Chen, Guohua; Priebe, David T., Short duration depot formulations.
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