초록 ▼

Methods and compositions, useful in the treatment of amyloidosis and conditions and diseases associated therewith, such as Alzheimer's Disease (AD). These methods involve administering to a subject a pharmaceutical composition including one or more agents which modulate APP catabolism and amyloid de

Methods and compositions, useful in the treatment of amyloidosis and conditions and diseases associated therewith, such as Alzheimer's Disease (AD). These methods involve administering to a subject a pharmaceutical composition including one or more agents which modulate APP catabolism and amyloid deposition. Accordingly, the methods and compositions are useful for inhibiting amyloidosis in disorders in which amyloid deposition occurs. The methods are based, at least in part, on modulating catabolism of APP in APP-containing cells through the use of a mobile ionophore, such as carbonyl cyanide p-(trifluoromethoxy)phenylhydrazone, which does not substantially alter the viability of those cells.

대표청구항 ▼

[ What is claimed is:] [1.]1. A packaged pharmaceutical composition for treating a disease state associated with amyloidosis, comprising in a container a therapeutically effective amount of a mobile ionophore composition effective to prevent or decrease amyloidosis precursor protein (AAP) catabolism

[ What is claimed is:] [1.]1. A packaged pharmaceutical composition for treating a disease state associated with amyloidosis, comprising in a container a therapeutically effective amount of a mobile ionophore composition effective to prevent or decrease amyloidosis precursor protein (AAP) catabolism in APP-containing cells without substantially altering the viability of said APP-containing cells and a pharmaceutically acceptable vehicle, and instructions for using the composition.