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Compounds and methods for synthesis and therapy 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-031/35
  • C07D-315/00
출원번호 US-0288091 (1999-04-08)
발명자 / 주소
  • Bischofberger Norbert W.
  • Kim Choung U.
  • Lew Willard
  • Liu Hongtao
  • Williams Matthew A.
출원인 / 주소
  • Gilead Sciences, Inc.
대리인 / 주소
    Bosse
인용정보 피인용 횟수 : 10  인용 특허 : 22

초록 ▼

Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting

대표청구항 ▼

[ What is claimed is:] [1.]1. A compound having the formula:T.sub.1 is --NHC(O)CH.sub.3, --NHC(O)CH.sub.2 F, --NHC(O)CHF.sub.2, or --NHC(O)CF.sub.3 ;G.sub.1 is guanidino, amino, or guanidino or amino substituted with C.sub.1 -C.sub.5 alkyl;U.sub.1 is C.sub.1 -C.sub.3 alkyl substituted with 1 to 3 C.

이 특허에 인용된 특허 (22)

  1. Ohira Yutaka,JPX, 4-substituted-2,7-dideoxy-7-fluoro-2,3-didehydro-sialic acid compounds.
    상세보기
  2. Cherry Peter,GBX ; Howes Peter,GBX ; Smith Paul,GBX ; Sollis Stephen,GBX, 6-Carboxamido dihydropyran derivatives.
    상세보기
  3. Kunisch Franz (Odenthal-Glbusch DEX) Babczinski Peter (Wuppertal DEX) Arlt Dieter (Kln DEX) Brandes Wilhelm (Leichlingen DEX) Dehne Heinz-Wilhelm (Monheim DEX) Dutzmann Stefan (Hilden DEX) Plempel Ma, Antimicrobial agents which are substituted 2-cyclohexan-1-yl-amine compounds..
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  4. Von Itzstein Laurence Mark (Victoria AUX) Wu Wen-Yang (Victoria AUX) Van Phan Tho (Victoria AUX) Danylec Basil (Victoria AUX) Jin Betty (Victoria AUX), Antiviral 4-substituted-2-deoxy-2,3-didehydro-derivatives of a 상세보기
  • Kim Choung U. (Foster City CA) Williams Matthew A. (Foster City CA), Aromatic compounds.
    상세보기
  • Farquhar David (Houston TX), Biologically reversible phosphate and phosphonate protective gruops.
    상세보기
  • Bischofberger Norbert W. ; Kim Choung U. ; Lew Willard ; Liu Hongtao ; Williams Matthew A., Carbocyclic compounds.
    상세보기
  • von Izstein Laurence M. (North Fitzray AUX) Wu Wen-Yang (Mount Waverley AUX) Phan Tho V. (Carnegie AUX) Danylec Basil (Box Hill AUX) Jin Betty (Mount Waverley AUX), Derivatives and analogues of 2-deoxy-2,3-didehydro-N-acetyl neuraminic acid and their use as antiviral agents.
    상세보기
  • Witiak Donald T. (Mt. Vernon OH) Rotella David P. (State College PA), Diastereomeric mono- and di-substituted diamino cyclohexane compounds and the method of preparation thereof.
    상세보기
  • Mueller Bernd (Frankenthal DEX) Brand Siegbert (Birkenheide DEX) Sauter Hubert (Mannheim DEX) Roehl Franz (Ludwigshafen DEX) Ammermann Eberhard (Heppenheim DEX) Lorenz Gisela (Neustadt DEX), Dihydropyran derivatives and crop protection agents containing them.
    상세보기
  • Andrews David,GBX ; Jones Paul,GBX ; Humber David,GBX, Dihydropyran derivatives as viral neuraminidase inhibitors.
    상세보기
  • Luo Ming ; White Clinton L., Inhibitors of bacterial sialidase and methods of making and using the same.
    상세보기
  • Bischofberger Norbert W. (San Carlos CA) Kent Kenneth M. (Sunnyvale CA), Method and cyclic carbonates for nucleotide analogues.
    상세보기
  • Bischofberger Norbert W. (San Carlos CA) Matteucci Mark D. (Burlingame CA), Nucleic acid intercalating agents.
    상세보기
  • Bischofberger Norbert (San Carlos CA) Kent Ken (Mountain View CA) Wagner Rick (Burlingame CA) Buhr Chris (Daly City CA) Lin Kuei-Ying (Fremont CA), Oligonucleotide analogs capable of passive cell membrane permeation.
    상세보기
  • Kent Kenneth M. ; Kim Choung U. ; McGee Lawrence R. ; Munger ; Jr. John D. ; Prisbe Ernest J. ; Postich Michael J. ; Rohloff John C. ; St. John Daphne E. ; Williams Matthew A. ; Zhang Lijun, Preparation of carbocyclic compounds.
    상세보기
  • Kent Kenneth M. ; Kim Choung U. ; McGee Lawrence R. ; Munger John D. ; Prisbe Ernest J. ; Postich Michael J. ; Rohloff John C. ; Kelly Daphne E. ; Williams Matthew A. ; Zhang Lijun, Preparation of carbocyclic compounds.
    상세보기
  • Searle Andrew D. (Stevenage GBX) Williamson Christopher (Dartford GBX), Process for the preparation of N-acetyl neuraminic acid derivatives.
    상세보기
  • Kunisch Franz (Odenthal-Gloebusch DEX) Babczinski Peter (Wuppertal DEX) Arlt Dieter (Cologne DEX) Santel Hans-Joachim (Leverkusen DEX) Schmidt Robert R. (Bergisch Gladbach DEX) Brandes Wilhelm (Leich, Substituted 2-cylcohexen-1-yl-amine fungicidal and herbicidal agents.
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  • Babu Yarlagadda S. (Birmingham AL) Chand Pooran (Birmingham AL) Walsh David A. (Birmingham AL), Substituted benzene derivatives useful as neuraminidase inhibitors.
    상세보기
  • Liav Avraham (Denver CO) Hardgrave Ragen F. (Cleveland TX) Blystone Sheri (Concord OH) Turner Gregory A. (Independence MO), Synthesis of 4-alkoxy-N-acetylneuraminic acid.
    상세보기
  • Mease Ronnie C. (Coram NY) Mausner Leonard F. (Stony Brook NY) Srivastava Suresh C. (Setauket NY), Synthesis of 4-substituted-trans-1, 2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation.
    상세보기

    • 이 특허를 인용한 특허 (10)

    1. Masaki, Hidekazu; Kageyama, Masayuki, Cyclic hydrocarbon compound.
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    2. Singer, Nicholas J., Delivery system for drinks.
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    3. Pero, Ronald W., Method for enhancing the DNA repair process, treating disorders associated with the DNA repair process, enhancing antitumor response and treating disorders associated with anti-tumor response in mammals by administering pruified quinic acid and/or carboxy alkyl ester.
      상세보기
    4. Pero, Ronald W., Method for enhancing the DNA repair process, treating disorders associated with the DNA repair process, enhancing antitumor response and treating disorders associated with anti-tumor response in mammals by administering purified quinic acid and/or carboxy alkyl ester.
      상세보기
    5. Stillman, Suzanne Jaffe, Method of hydration; infusion packet system(s), support member(s), delivery system(s), and method(s); with business model(s) and Method(s).
      상세보기
    6. Pero, Ronald W., Method of preparation and composition of a water soluble extract of the bioactive component of the plant species Uncaria for enhancing immune, anti-inflammatory, anti-tumor and DNA repair processes of warm blooded animals.
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    7. Singer, Nicholas J., Package.
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    8. Singer, Nicholas J., Package.
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    9. Brown,Jack D.; Harrington,Peter J.; Hughes,Robert C., Process for preparing 1,2-diamino compounds.
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    10. Hilfinger, John; Amidon, Gordon, Prodrugs of neuraminidase inhibitors.
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