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Methods and compositions for the dry powder formulation of interferons 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-038/21
  • C07K-001/36
출원번호 US-0737724 (1997-07-14)
국제출원번호 PCT/US95/06008 (1995-05-15)
§371/§102 date 19970714 (19970714)
국제공개번호 WO-9531479 (1995-11-23)
발명자 / 주소
  • Platz Robert M.
  • Kimura Shigenobu,JPX
  • Satoh Yu-ichiro,JPX
  • Foster Linda C.
출원인 / 주소
  • Inhale Therapeutic Systems
대리인 / 주소
    Evans
인용정보 피인용 횟수 : 55  인용 특허 : 9

초록 ▼

According to the present invention, methods and compositions are provided for spray-dried, interferon-based dry powder compositions, particularly interferon-beta. The compositions are useful for treating conditions in humans that are responsive to treatment with interferons. In particular, the metho

대표청구항 ▼

[ The subject matter claimed is:] [1.]1. A spray-dried, bioactive interferon-.beta.-based dry powder composition, which, when administered pulmonarily, is rapidly systemically absorbed, comprising a therapeutically effective amount of an interferon-.beta. in combination with a pharmaceutically accep

이 특허에 인용된 특허 (9)

  1. Kwan Henry K. H. (Summit NJ), Biologically stable interferon compositions comprising thimerosal.
    상세보기
  2. Mitsuhashi Masakazu (Okayama JPX) Sakai Shuzo (Okayama JPX) Miyake Toshio (Okayama JPX), Dehydration of hydrous matter using anhydrous glycosylfructose.
    상세보기
  3. Radhakrishnan Ramachandran (Fremont CA) Mihalko Paul J. (Fremont CA) Abra Robert M. (San Francisco CA), Method and apparatus for administering dehydrated liposomes by inhalation.
    상세보기
  4. Radhakrishnan Ramachandran (Fremont CA), Novel liposome composition for the treatment of interstitial lung diseases.
    상세보기
  5. Suzuki Yoshiki (Tokyo JPX) Sekine Kunio (Tokyo JPX) Nagai Tsuneji (Tokyo JPX) Nambu Naoki (Kanagawa JPX) Nishimoto Yuji (Tokyo JPX), Powdery pharmaceutical composition for nasal administration.
    상세보기
  6. Platz Robert M. (Half Moon Bay CA) Ip Anna (Moorpark CA) Whitham Clyde L. (Montara CA), Process for preparing micronized polypeptide drugs.
    상세보기
  7. Pestka Sidney (North Caldwell NJ) Rubinstein Menachem (Rimon ILX), Protein purification process and product.
    상세보기
  8. Pitt Colin G. (Thousand Oaks CA) Platz Robert M. (Half Moon Bay CA), Pulmonary administration of erythropoietin.
    상세보기
  9. Platz Robert M. (Half Moon Bay CA) Winters Mark A. (Mountain View CA) Pitt Colin G. (Thousand Oaks CA), Pulmonary administration of granulocyte colony stimulating factor.
    상세보기

이 특허를 인용한 특허 (55)

  1. Cox, Kenneth A.; Beane, Timothy Paul; Sweeney, William R., Aerosol generator and methods of making and using an aerosol generator.
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  2. Cox, Kenneth A.; Beane, Timothy Paul; Sweeney, William R.; Nichols, Walter A.; Sprinkel, Jr., F. Murphy, Aerosol generator and methods of making and using an aerosol generator.
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  3. Cox,Kenneth A.; Beane,Timothy Paul; Sweeney,William R.; Nichols,Walter A.; Sprinkel, Jr.,F. Murphy, Aerosol generator and methods of making and using an aerosol generator.
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  4. Sprinkel, Jr., F. Murphy; Nichols, Walter A., Aerosol generator having a multiple path heater arrangement and method of use thereof.
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  5. Sherwood, Timothy S.; Sowers, Scott A.; Reddy, Sirisha P.; Sprinkel, Jr., F. Murphy; Cox, Kenneth A.; Nichols, Walter A., Aerosol generator having heater arranged to vaporize fluid in fluid passage between bonded layers of laminate.
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  6. Sprinkel, Jr., F. Murphy; Nichols, Walter A.; Cox, Kenneth A.; Sherwood, Timothy S.; Sowers, Scott A.; Washington, Zelita R.; Reddy, Sirisha, Aerosol generator having heater in multilayered composite and method of use thereof.
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  7. Sharpe, David E.; Felter, John L., Aerosol generator having inductive heater and method of use thereof.
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  8. Kenneth A. Cox ; Walter A. Nichols ; F. Murphy Sprinkel, Jr. ; Douglas D. McRae ; William R. Sweeney, Aerosol generator having multiple heating zones and methods of use thereof.
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  9. Cox,Kenneth A.; Nichols,Walter A.; Sprinkel, Jr.,F. Murphy; McRae,Douglas D.; Sweeney,William R., Aerosol generator having temperature controlled heating zone and method of use thereof.
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  10. Yamashita,Chikamasa; Ibaragi,Shigeru; Fukunaga,Yuichiro; Akagi,Akitsuna, Composition, vessel, dry powder inhalation system, and related methods for transpulmonary administration.
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  11. Nichols, Walter A.; Sprinkel, Jr., F. Murphy, Disposable aerosol generator system and methods for administering the aerosol.
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  12. Nichols,Walter A.; Sprinkel, Jr.,F. Murphy, Disposable aerosol generator system and methods for administering the aerosol.
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  13. Nichols,Walter A.; Sprinkel, Jr.,F. Murphy, Disposable inhaler system.
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  14. Nichols,Walter A.; Sprinkel, Jr.,F. Murphy, Disposable inhaler system.
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  15. Yamashita, Chikamasa; Ibaragi, Shigeru; Fukunaga, Yuichiro; Akagi, Akitsuna, Dry powder inhalation system for transpulmonary administration.
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  16. Yamashita, Chikamasa; Ibaragi, Shigeru; Fukunaga, Yuichiro; Akagi, Akitsuna, Dry powder inhalation system for transpulmonary administration.
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  17. Lord, John; Jouhikainen, Jaakko Taneli; Snyder, Herman E.; Soni, Pravin; Kuo, Mei-Chang, Dry powder vancomycin compositions and associated methods.
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  18. Nichols, Walter A.; Cox, Kenneth A.; Nguyen, Tung Tien, Dual capillary fluid vaporizing device.
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  19. Nichols, Walter A.; Cox, Kenneth A.; Nguyen, Tung Tien, Dual capillary fluid vaporizing device.
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  20. Sommer, Sabrina; Kiesele, Herbert; Mett, Frank, Electrochemical sensor having a mediator compound.
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  21. Tarara, Thomas E.; Weers, Jeffry G.; Kabalnov, Alexey; Schutt, Ernest G.; Dellamary, Luis A., Engineered particles and methods of use.
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  22. Tarara,Thomas E.; Weers,Jeffry G.; Kabalnov,Alexey; Schutt,Ernest G.; Dellamary,Luis A., Engineered particles and methods of use.
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  23. Faison, Jr.,Gene G.; Gupta,Rajiv; McRae,Douglas D.; Nichols,Walter A., Fluid vaporizing device having controlled temperature profile heater/capillary tube.
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  24. Nichols, Walter A.; Cox, Kenneth A.; McRae, Douglas D.; Nguyen, Tung Tien, Fluid vaporizing device having controlled temperature profile heater/capillary tube.
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  25. Tarara, Thomas E.; Weers, Jeffry G.; Eldon, Michael A.; Narashimhan, Rangachari; Clark, Andrew, Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use.
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  26. Lipp, Michael W.; Batycky, Richard P.; Caponetti, Giovanni, Formulation for spray-drying large porous particles.
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  27. Byron,Peter R.; Hindle,Michael, Method and apparatus for generating an aerosol.
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  28. Hindle, Michael; Byron, Peter R.; Gupta, Rajiv, Method for generating an aerosol with a predetermined and/or substantially monodispersed particle size distribution.
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  29. Patton, John S.; Foster, Linda S.; Platz, Robert M., Methods and compositions for pulmonary delivery of insulin.
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  30. Robert M. Platz ; Shigenobu Kimura JP; Yu-ichiro Satoh JP; Linda C. Foster, Methods and compositions for the dry powder formulation of interferons.
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  31. Liu, Dongfang; Qi, Yiwei; Venkataraman, Ganesh; Sundaram, Mallikarjun; Sasisekharan, Ram, Methods and products related to pulmonary delivery of polysaccharides.
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  32. Hindle, Michael; Byron, Peter R.; Hong, John N., Mouthpiece entrainment airflow control for aerosol generators.
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  33. Edwards, David A.; Hrkach, Jeffrey S., Particles for inhalation having sustained release properties.
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  34. Batycky,Richard P.; Edwards,David A.; Lipp,Michael M., Particulate compositions for pulmonary delivery.
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  35. Batycky,Richard P.; Edwards,David A.; Lipp,Michael M., Particulate compositions for pulmonary delivery.
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  36. Weers, Jeffry G.; Tarara, Thomas E.; Dellamary, Luis A.; Riess, Jean G.; Schutt, Ernest G., Phospholipid-based powders for drug delivery.
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  37. Weers, Jeffry G; Tarara, Thomas E; Dellamary, Luis A; Riess, Jean G; Schutt, Ernest G, Phospholipid-based powders for drug delivery.
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  38. Richardson, Thomas; Venkataraman, Ganesh; Qi, Yiwei; Picard, Michele, Polysaccharides for pulmonary delivery of active agents.
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  39. Patton,John S., Pulmonary delivery of active fragments of parathyroid hormone.
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  40. Tarara, Thomas E.; Weers, Jeffry G.; Venthoye, Geraldine, Pulmonary delivery of aminoglycoside.
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  41. Tarara, Thomas E; Weers, Jeffry G; Venthoye, Maria Geraldine, Pulmonary delivery of aminoglycoside.
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  42. Tarara, Thomas E.; Weers, Jeffrey G.; Kabalnov, Alexey; Schutt, Ernest G.; Dellamary, Luis A., Pulmonary delivery particles comprising an active agent.
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  43. Weers, Jeffry G.; Schutt, Ernest G.; Dellamary, Luis A.; Tarara, Thomas E.; Kabalnov, Alexey, Respiratory dispersion for metered dose inhalers comprising perforated microstructures.
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  44. Roser, Bruce J.; Kampinga, Jaap; Colaco, Camilo; Blair, Julian, Solid dose delivery vehicle and methods of making same.
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  45. Roser, Bruce J.; Kampinga, Jaap; Colaco, Camilo; Blair, Julian, Solid dose delivery vehicle and methods of making same.
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  46. Roser, Bruce J.; Kampinga, Jaap; Colaco, Camilo; Blair, Julian, Solid dose delivery vehicle and methods of making same.
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  47. Wolfe, Sidney N.; Hora, Maninder S., Stabilized interferon compositions.
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  48. Weers, Jeffry G.; Schutt, Ernest G.; Dellamary, Luis; Tarara, Thomas E.; Kabalnov, Alexey, Stabilized preparations for use in metered dose inhalers.
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  49. Dellamary, Luis A.; Reiss, Jean; Schutt, Ernest G.; Weers, Jeffry G.; Tarara, Thomas E., Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery.
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  50. Dellamary, Luis A.; Riess, Jean; Schutt, Ernest G.; Weers, Jeffry G.; Tarara, Thomas E., Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use.
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  51. Dellamary, Luis A; Riess, Jean; Schutt, Ernest G; Weers, Jeffry G; Tarara, Thomas E, Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use.
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  52. Edwards, David A.; Hrkach, Jeffrey S., Stable spray-dried protein formulations.
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  53. Batycky,Richard P.; Lipp,Michael M.; Niven,Ralph W., Use of simple amino acids to form porous particles.
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  54. Batycky, Richard P.; Lipp, Michael M.; Niven, Ralph W., Use of simple amino acids to form porous particles during spray drying.
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  55. Walter A. Nichols, Vapor driven aerosol generator and method of use thereof.
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