초록 ▼

A glucose monitor, and related method, determines the concentration of glucose in a sample with water, using a predictive regression model. The glucose monitor illuminates the sample with ultraviolet excitation light that induces the water and any glucose present in the sample to emit return light t

A glucose monitor, and related method, determines the concentration of glucose in a sample with water, using a predictive regression model. The glucose monitor illuminates the sample with ultraviolet excitation light that induces the water and any glucose present in the sample to emit return light that includes raman scattered light and glucose emission or fluorescence light. The return light is monitored and processed using a predictive regression model to determine the concentration of glucose in the sample. The predictive regression model accounts for nonlinearities between the glucose concentration and intensity of return light within different wavelength bands at a predetermined excitation light energy or the intensity of return light within a predetermined wavelength band at different excitation energy levels. A fiber-optic waveguide is used to guide the excitation light from a laser excitation source to the sample and the return light from the sample to a sensor.

대표청구항 ▼

[ We claim:] [1.]1. Apparatus for determining the concentration of glucose in a sample that includes water, comprising:a light source that emits ultraviolet excitation light of at least one predetermined energy level, that is directed at a sample to produce return light from the sample, such return

[ We claim:] [1.]1. Apparatus for determining the concentration of glucose in a sample that includes water, comprising:a light source that emits ultraviolet excitation light of at least one predetermined energy level, that is directed at a sample to produce return light from the sample, such return light including induced emission of light produced as a result of interactions between the excitation light and any glucose with water present in the sample;a sensor that monitors the return light and generates at least three electrical signals indicative of the intensity of return light associated with glucose concentration distinguishing characteristics of the emission light, the at least three electrical signals including at least two electrical signals indicative of the intensity of return light at a respective number of wavelengths within a predetermined, narrow wavelength band corresponding to at least one characteristic narrow spectral peak, and a third electrical signal indicative of the intensity of return light within a predetermined, narrow wavelength band outside of the narrow spectral peak; anda processor that processes the electrical signals, using a predictive model, to determine the concentration of glucose in the sample.