초록 ▼

Methods and formulations for making extended release bupropion hydrochloride tablets using direct compression, and tablets formed thereby, are provided which combine bupropion hydrochloride, binders such as polyethylene oxide or hydroxypropyl cellulose, a filler such as lactose, glidants and lubrica

Methods and formulations for making extended release bupropion hydrochloride tablets using direct compression, and tablets formed thereby, are provided which combine bupropion hydrochloride, binders such as polyethylene oxide or hydroxypropyl cellulose, a filler such as lactose, glidants and lubricants under low shear conditions to form hard, chip-resistant tablets which exhibit improved cohesiveness and are easily and reproducibly formed without adhering to the compression punches and dies.

대표청구항 ▼

[ We claim:] [1.]1. A method for tableting bupropion hydrochloride by direct compression without employing a slugging or wet granulation step comprising the steps of:(a) weighing bupropion hydrochloride and exicipients, said bupropion hydrochloride having a particle size of from about 130 to about 4

[ We claim:] [1.]1. A method for tableting bupropion hydrochloride by direct compression without employing a slugging or wet granulation step comprising the steps of:(a) weighing bupropion hydrochloride and exicipients, said bupropion hydrochloride having a particle size of from about 130 to about 450 microns and a density of from about 0.44 to about 0.66 g/ml;(b) combining the bupropion hydrochloride and the excipients to form a directly compressible formulation; and(c) directly compressing the formulation to form bupropion hydrochloride tablets.