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Compositions and methods for treatment of neoplastic diseases with combinations of limonoids, flavonoids and tocotrienols 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-031/70
출원번호 US-0481963 (2000-01-12)
발명자 / 주소
  • Guthrie Najla,CAX
  • Kurowska Elzbieta Maria,CAX
출원인 / 주소
  • KGK Synergize, CAX
대리인 / 주소
    Davidson, Davidson & Kappel, LLC
인용정보 피인용 횟수 : 39  인용 특허 : 15

초록 ▼

Compositions and methods for the prevention and treatment of neoplastic diseases are described. Individuals at a high risk of developing or having neoplasia undergoing conventional therapies may be treated with an effective dose of triterpene derivatives in limonoids, polyphenolic flavonoid compound

대표청구항 ▼

[ What is claimed is:] [1.]1. A pharmaceutical composition comprising a synergistic combination of at least two compounds selected from the group consisting of a limonoid, a flavonoid and a tocotrienol for treating a mammal at risk of or suffering from cancer, said composition exhibiting synergistic

이 특허에 인용된 특허 (15)

  1. Lanzendorfer Ghita,DEX ; Stab Franz,DEX ; Untiedt Sven,DEX, Agents acting against hyperreactive and hypoactive, deficient skin conditions and manifest dermatitides.
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  2. Hasegawa Shin (Pasadena CA) Lam Luke K. T. (North Oaks MN), Antitumor agent.
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  3. Bombardelli Ezio,ITX ; Mancuso Salvatore,ITX ; Delle Monache Franco,ITX, Chalcones and esters thereof with antiproliferative activity in uterus, ovary and breast tumors.
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  4. Burger Warren C. (Mt. Horeb WI) Qureshi Asaf A. (Madison WI) Elson Charles E. (Madison WI), Cholesterol lowering method of use.
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  5. Hollenbach Edward J. (Brookville IN) Howard Norman B. (Oxford OH), Emulsion concentrate for palatable polyester beverage.
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  6. Haast William E. (34879 Washington Loop Rd. Punta Gorda FL 33982) Harrell Nancy G. (34879 Washington Loop Rd. Punta Gorda FL 33982), Lyophilized health food products and methods of making same.
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  7. Perricone Nicholos V. (35 Pleasant St. Meriden CT 06450), Method and compositions for topical application to the skin of tocotrienol for prevention and/or treatment of skin damag.
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  8. Elson Charles E., Method of suppressing tumor growth with combinations of isoprenoids and statins.
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  9. Ghai Geetha ; Boyd Charles ; Csiszar Katalin ; Ho Chi-Tang ; Rosen Robert T., Methods of screening foods for nutraceuticals.
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  10. Bombardelli Ezio,ITX ; Morazzoni Paolo,ITX, Pharmaceutical compositions containing flavanolignanes and methods for using same as an antiproliferative.
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  11. Finney David John (Palmerston North NZ), Soft ice cream.
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  12. Lane Ronald H. ; Qureshi Asaf A. ; Salser Winston A., Tocotrienols and tocotrienol-like compounds and methods for their use.
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  13. Lane Ronald H. ; Qureshi Asaf A. ; Salser Winston A., Tocotrienols and tocotrienol-like compounds and methods for their use.
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  14. Wright John J. (North Guilford CT) Pearce Bradley C. (East Hampton CT) Parker Rex (Branford CT) Qureshi Asaf A. (Madison WI), Tocotrienols in the treatment of hypercholesterolemia, hyperlipidemia and thromboembolic disorders.
    상세보기
  15. Prochaska Hans J. (New York NY) Scotto Kathleen W. (Middle Village NY), Use of flavonoids to treat multidrug resistant cancer cells.
    상세보기

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  4. Zhou, Jia; Hellmich, Mark; Szabo, Csaba, Apigenin analogs, compositions, and methods related thereto.
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  7. Ogle, Matthew F.; Carlyle, Wenda C.; Anderson, Edward J.; Udipi, Kishore, Coated balloons for blood vessel stabilization.
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  9. Guthrie, Najla, Compositions and methods for glycemic control of subjects with impaired fasting glucose.
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  10. Guthrie, Najla, Compositions and methods for glycemic control of subjects with impaired fasting glucose.
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  11. Guthrie, Najla; Kurowska, Elzbieta Maria; Manthey, John A., Compositions and methods of treating, reducing and preventing cardiovascular diseases and disorders with polymethoxyflavones.
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  12. Kulikowski, Ewelina B.; Gilham, Dean E.; Wasiak, Sylwia; Halliday, Christopher R. A.; Tsujikawa, Laura M., Compositions and therapeutic methods for the treatment of complement-associated diseases.
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  13. Hansen, Henrik C., Compounds for the prevention and treatment of cardiovascular disease.
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  14. Hansen, Henrik C., Compounds for the prevention and treatment of cardiovascular diseases.
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  15. Hansen, Henrik C., Compounds for the prevention and treatment of cardiovascular diseases.
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  16. Hansen, Henrik C., Compounds for the prevention and treatment of cardiovascular diseases.
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  17. Fairfax, David John; Duffy, Bryan Cordell; Martin, Gregory Scott; Quinn, John Frederick; Liu, Shuang; Wagner, Gregory Steven; Young, Peter Ronald, Cyclic amines as bromodomain inhibitors.
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  18. Fairfax, David John; Duffy, Bryan Cordell; Martin, Gregory Scott; Quinn, John Frederick; Liu, Shuang; Wagner, Gregory Steven; Young, Peter Ronald, Cyclic amines as bromodomain inhibitors.
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  19. Malafa, Mokenge P.; Sebti, Said M., Delta-tocotrienol treatment and prevention of pancreatic cancer.
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  20. Ogle, Matthew F.; Anderson, Edward J.; Reil, Todd D.; Carlyle, Wenda C., Devices, therapeutic compositions and corresponding percutaneous treatment methods for aortic dissection.
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  21. Vyavahare, Narendra R.; Isenburg, Jason C.; Simionescu, Dan T., Elastin stabilization of connective tissue.
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  22. Vyavahare, Narendra R.; Isenburg, Jason C.; Simionescu, Dan T., Elastin stabilization of connective tissue.
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  23. Vyavahare, Narendra R.; Isenburg, Jason C.; Simionescu, Dan T., Elastin stabilization of connective tissue.
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  24. Vyavahare,Narendra R.; Isenburg,Jason C.; Simionescu,Dan T., Elastin stabilization of connective tissue.
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  25. Huang,Mou Tuan; Ho,Chi Tang; Rosen,Robert T.; Ghai,Geetha; Lipkin,Martin; Chen,Kuang Yu; Telang,Nitin; Boyd,Charles; Csiszar,Katalin, Extracts of orange peel for prevention and treatment of cancer.
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  26. Zaloga, Gary P.; Siddiqui, Rafat; Stillwell, William, Fatty acid phenolic conjugates.
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  27. Wong, Norman C. W.; Tucker, Joseph E. L.; Hansen, Henrik C.; Chiacchia, Fabrizio S.; McCaffrey, David, Flavanoids and isoflavanoids for the prevention and treatment of cardiovascular diseases.
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  28. Wong, Norman C. W.; Tucker, Joseph E. L.; Hansen, Henrik C.; Chiacchia, Fabrizio S.; McCaffrey, David, Flavanoids and isoflavanoids for the prevention and treatment of cardiovascular diseases.
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  29. Liu, Shuang; Duffy, Bryan Cordell; Quinn, John Frederick; Jiang, May Xiaowu; Wang, Ruifang; Martin, Gregory Scott; Zhao, He; Molino, Bruce Francis; Young, Peter Ronald, Heterocyclic compounds as bromodomain inhibitors.
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  30. van Praag, Henriette; Gage, Fred H.; Hammerstone, John; Kelm, Mark Allen, Method for increasing cognitive function and neurogenesis.
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  31. Hansen, Henrik C.; Chopade, Shubham P.; Citineni, Janakiram R.; Short, Robert P.; Yiannikouros, George P., Methods of preparing quinazolinone derivatives.
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  32. Crouse, Jeremy; Rivera, Teodoro; Given, Jr., Peter S., Microencapsulated citrus phytochemicals and application to beverages.
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  33. Shenoy, Narmada R., Pharmaceutical compositions for substituted quinazolinones.
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  34. Shenoy, Narmada R., Pharmaceutical compositions for substituted quinazolinones.
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  35. Wong, Norman C. W.; Hansen, Henrik C.; Chiacchia, Fabrizio S.; Johansson, Jan O., Pharmaceutical compositions for the prevention and treatment of complex diseases and their delivery by insertable medical devices.
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  36. Udell, Ronald G., Soft gel capsules containing polymethoxylated flavones and palm oil tocotrienols.
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  37. Wong, Norman C. W.; Tucker, Joseph E. L.; Hansen, Henrik C.; Chiacchia, Fabrizio S.; McCaffrey, David, Stilbenes and chalcones for the prevention and treatment of cardiovascular diseases.
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  38. Hasler Nguyen,Nathalie; Zijlstra,Jacob; Troup,John P., Synergistic antioxidant combination of delta tocols and polyphenols.
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  39. Simionescu, Agneta; Simionescu, Dan; Chow, James, Treatment to render implants resistant to diabetes.
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