초록 ▼

and their use in treating psychiatric disorders and neurological diseases, anxiety-related disorders, post-traumatic stress disorder, supranuclear palsy and feeding disorders as well as treatment of immunological, cardiovascular or heart-related diseases and colonic hypersensitivity associated with

and their use in treating psychiatric disorders and neurological diseases, anxiety-related disorders, post-traumatic stress disorder, supranuclear palsy and feeding disorders as well as treatment of immunological, cardiovascular or heart-related diseases and colonic hypersensitivity associated with psychopathological disturbance and stress in mammals.

대표청구항 ▼

[ What is claimed is:] [1.]1. A compound of Formula (I) isomers thereof, stereoisomeric forms thereof, or mixtures of stereoisomeric forms thereof, and pharmaceutically acceptable salt forms thereof wherein:Q is selected from the group consisting of:X is N or CR.sup.1 ;Y and Z are independently N or

[ What is claimed is:] [1.]1. A compound of Formula (I) isomers thereof, stereoisomeric forms thereof, or mixtures of stereoisomeric forms thereof, and pharmaceutically acceptable salt forms thereof wherein:Q is selected from the group consisting of:X is N or CR.sup.1 ;Y and Z are independently N or CR.sup.2 ;U and V are independently >C.dbd.G, CR.sup.13 R.sup.14, NR.sup.13, O, or S without forming O--O, S--O, or S--S bonds;G is O or S;R.sup.1 is independently at each occurrence --H, halogen, --CN, C.sub.1 -C.sub.4 -haloalkyl, --NR.sup.9 R.sup.10, --NR.sup.9 COR.sup.9, --COR.sup.10, --OR.sup.10, SH, --S(O).sub.n R.sup.12, C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl, C.sub.3 -C.sub.6 cycloalkyl, or C.sub.4 -C.sub.8 cycloalkylalkyl, where each C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl, C.sub.3 -C.sub.6 cycloalkyl, and C.sub.4 -C.sub.8 cycloalkylalkyl are optionally substituted with halogen, --CN, C.sub.1 -C.sub.4 haloalkyl, --NR.sup.9 R.sup.10, --NR.sup.9 COR.sup.9, --COR.sup.10, --OR.sup.10, SH or --S(O).sub.n R.sup.12 ;R.sup.2 is --H, halogen, --CN, C.sub.1 -C.sub.4 haloalkyl, --NR.sup.9 R.sup.10, --NR.sup.9 COR.sup.9, --COR.sup.10, --OR.sup.10, SH, --S(O).sub.n R.sup.12, C.sub.1 -C.sub.4 alkyl, C.sub.3 -C.sub.6 cycloalkyl or C.sub.3 -C.sub.7 cycloalkylalkyl, where each C.sub.1 -C.sub.4 alkyl, C.sub.3 -C.sub.6 cycloalkyl, and C.sub.3 -C.sub.7 cycloalkylalkyl are optionally substituted with halogen, CN, C.sub.1 -C.sub.4 haloalkyl, --NR.sup.9 R.sup.10, NR.sup.9 COR.sup.9, --COR.sup.10, --OR.sup.10, SH or --S(O).sub.n R.sup.12 ;R.sup.3 is C.sub.1 -C.sub.10 alkyl, C.sub.2 -C.sub.10 alkenyl, C.sub.2 -C.sub.10 alkynyl, C.sub.3 -C.sub.8 cycloalkyl, C.sub.4 -C.sub.12 cycloalkylalkyl, C.sub.2 -C.sub.10 alkoxyalkyl, C.sub.5 -C.sub.10 cycloalkenyl, or C.sub.5 -C.sub.10 cycloalkenylalkyl, where one carbon in any cycloalkyl ring may be replaced with O, S or NR.sup.9 and each C.sub.1 -C.sub.10 alkyl, C.sub.2 -C.sub.10 alkenyl, C.sub.2 -C.sub.8 alkynyl, C.sub.3 -C.sub.8 cycloalkyl, C.sub.4 -C.sub.12 cycloalkylalkyl, C.sub.2 -C.sub.10 alkoxyalkyl, C.sub.5 -C.sub.10 cycloalkenyl, and C.sub.5 -C.sub.10 cycloalkenylalkyl are optionally substituted with 1 to 3 substituents independently selected at each occurrence from C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.10 alkynyl, C.sub.3 -C.sub.6 cycloalkyl, halogen, C.sub.1 -C.sub.4 haloalkyl, cyano, --OR.sup.7, SH, --S(O).sub.n R.sup.11, --COR.sup.6, --NHR.sup.6 SO.sub.2 R.sup.8, --OC(O)NR.sup.6 R.sup.7, --N.sub.3, --OC(O)OR.sup.7, --CO.sub.2 R.sup.8, --OC(O)R.sup.6, --NR.sup.7 COR.sup.6, --N(COR.sup.6).sub.2, --NR.sup.7 CONR.sup.6 R.sup.7, --NR.sup.7 CO.sub.2 R.sup.8, --NR.sup.6 R.sup.7, --CONR.sup.6 R.sup.7, --CO.sub.2 H, aryl, heteroaryl and heterocyclyl;alternatively, R3 is --OR.sup.3a, --NR.sup.3a R.sup.3a, --NHR.sup.3a, --SO.sub.n R.sup.3a, --SO.sub.2 NHR.sup.3a, --SO.sub.2 NR.sup.3a R.sup.3b, --COR.sup.3a, --CONHR.sup.3a, or CONR.sup.3a R.sup.3b ;R.sup.3a and R.sup.3b are independently C.sub.1 -C.sub.10 alkyl, C.sub.2 -C.sub.10 alkenyl, C.sub.2 -C.sub.10 alkynyl, C.sub.3 -C.sub.8 cycloalkyl, C.sub.4 -C.sub.12 cycloalkylalkyl, C.sub.2 -C.sub.10 alkoxyalkyl, C.sub.5 -C.sub.10 cycloalkenyl, or C.sub.5 -C.sub.10 cycloalkenylalkyl, where one carbon in any cycloalkyl may be replaced with O, S or NR.sup.9 and each C.sub.1 -C.sub.10 alkyl, C.sub.2 -C.sub.10 alkenyl, C.sub.2 -C.sub.10 alkynyl, C.sub.3 -C.sub.8 cycloalkyl, C.sub.4 -C.sub.12 cycloalkylalkyl, C.sub.2 -C.sub.10 alkoxyalkyl, C.sub.5 -C.sub.10 cycloalkenyl, and C.sub.5 -C.sub.10 cycloalkenylalkyl are optionally substituted with 1 to 3 substituents independently selected at each occurrence from C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.10 alkynyl, C.sub.3 -C.sub.6 cycloalkyl, halogen, C.sub.1 -C.sub.4 haloalkyl, cyano, --OR.sup.7, --SH, --S(O).sub.n R.sub.11, --COR.sup.6, --CO.sub.2 R.sup.8, --OC(O)R.sup.6, --NR.sup.7 COR.sup.6, --N(COR.sup.6).sub.2, --NR.sup.7 CONR.sup.6 R.sup.7, --NR.sup.7 CO.sub.2 R.sup.8, --NR.sup.6 R.sup.7, --NHR.sup.6 SO.sub.2 R.sup.8, --OC(O)NR.sup.6 R.sup.7, --N.sub.3, --OC(O)OR.sup.7, --CONR.sup.6 R.sup.7, --CO.sub.2 H, aryl, heteroaryl and heterocyclyl;L is C(R.sup.4).sub.2 C(R.sup.4).sub.2 or CR.sup.4.dbd.CR.sup.4 ;R.sup.4 is independently selected in each occurrence from H, --OR.sup.10, --COR.sup.9, --C.sub.2, R.sup.8, --CONR.sup.9 R.sup.10, --CN, --NR.sup.9 R.sup.10, --S(O).sub.n R.sup.12, halogen, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.4 haloalkyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl, aryl or heteroaryl, where in C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.4 haloalkyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.2 -C.sub.6 alkenyl, and C.sub.2 -C.sub.6 alkynyl are optionally substituted with --OR.sup.10, --COR.sup.9, --CO.sub.2 R.sup.8, --CONR.sup.9 R]O, --CN, --NR.sup.9 R.sup.10, --S(O).sub.n R.sup.12 or halogen;A.sup.1 -A.sup.4 are each CR.sup.5 ;R.sup.5 is independently at each occurrence --H, C.sub.1 -C.sub.10 alkyl, C.sub.1 -C.sub.4 haloalkyl, C.sub.1 -C.sub.4 haloalkoxy, C.sub.2 -C.sub.10 alkenyl, C.sub.2 -C.sub.10 alkynyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.4 -C.sub.12 cycloalkylalkyl, --NO.sub.2, halogen, --CN, --NR.sup.6 R.sup.7, --NR.sup.6 CO R.sup.7, --NR.sup.6 CO .sub.2 R.sup.8, --CO R.sup.6 --O R.sup.7, --CONR.sup.6 R.sup.7, --CO(NOR.sup.9)R.sup.11, --CO.sub.2 R.sup.8, or --S(O).sub.n R.sup.11, where C.sub.1 -C.sub.10 alkyl, C.sub.2 -C.sub.10 alkenyl, C.sub.2 -C.sub.10 alkynyl, C.sub.3 -C.sub.6 cycloalkyl and C.sub.4 -C.sub.12 cycloalkylalkyl are optionally substituted with i to 3 substituents independently selected at each occurrence from C.sub.1 -C.sub.4 alkyl, C.sub.2 -C.sub.4 alkenyl, C.sub.2 -C.sub.4 alkynyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.4 -C.sub.8 cycloalkylalkyl, C.sub.1 -C.sub.4 haloalkyl, --NO.sub.2, halogen, --CN, --NR.sup.6 R.sup.7, --NR.sup.6 COR.sup.7, NR.sup.6 CO.sub.2 R.sup.8, --COR.sup.6 --OR.sup.7, --CONR.sup.6 R.sup.7, --CO.sub.2 R.sup.8, --CO(NOR.sup.9)R.sup.7, an d --S(O).sub.n R.sup.11 and wherein two adjacent R.sup.5 groups can form a 5-7 membered ring saturated or unsaturated optionally containing 1-2 O or SON or 1-3 N heteroatoms and optionally substituted with C.sub.1 -C.sub.4 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.4 -C.sub.8 cycloalkylalkyl, C.sub.1 -C.sub.4 haloalkyl, --NO.sub.2, halogen, --CN, --NR.sup.6 R.sup.7, --NR.sup.6 COR.sup.7, --NR.sup.6 CO.sub.2 R.sup.8, --COR.sup.6 --OR.sup.7, --CONR.sup.6 R.sup.7, --CO.sub.2 R.sup.8, --CO(NOR.sup.9)R.sup.7, or --S(O).sub.n R.sup.11 and not containing any S--S, O--O, S--O or N--S bonds in the ring;R.sup.6 and R.sup.7 are independently at each occurrence H, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.4 haloalkyl, C.sub.2 -C.sub.8 alkoxyalkyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.4 -C.sub.12 cycloalkylalkyl, C.sub.5 -C.sub.12 bis(alkoxy)alkyl, aryl, aryl(C.sub.1 -C.sub.4 alkyl)-, heteroaryl, heteroaryl(C.sub.1 -C.sub.4 alkyl) or NR.sup.6 R.sup.7 is piperidine, pyrrolidine, piperazine, N-methylpiperazine, morpholine or thiomorpholine;R.sup.8 is independently at each occurrence C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.4 -C.sub.12 cycloalkylalkyl, aryl, aryl(C.sub.1 -C.sub.4 alkyl), heteroaryl or heteroaryl(C.sub.1 -C.sub.4 alkyl);R.sup.9 and R.sup.10 are independently at each occurrence selected from H, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, C.sub.3 -C.sub.6 alkenyl, C.sub.3 -C.sub.6 alkynyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.2 -C.sub.6 alkoxyalkyl, or C.sub.4 -C.sub.7 cycloalkylalkyl;R.sup.11 is independently at each occurrence C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.4 -C.sub.12 cycloalkylalkyl, aryl, aryl(C.sub.1 -C.sub.4 alkyl), heteroaryl, heteroaryl(C.sub.1 -C.sub.4 alkyl), or --NR.sup.6 R.sup.7 ;R.sup.12 is independently at each occurrence C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, C.sub.3 -C.sub.6 alkenyl, C.sub.3 -C.sub.6 alkynyl, C.sub.3 -C.sub.6 cycloalkyl, or C.sub.4 -C.sub.7 cycloalkylalkyl;R.sup.13 and R.sup.14, are independently at each occurrence H, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.4 -C.sub.12 cycloalkylalkyl, aryl, aryl(C.sub.1 -C.sub.4 alkyl), heteroaryl, heteroaryl(C.sub.1 -C.sub.4 alkyl)-, --COR.sup.12, --CO.sub.2 R.sup.8, --CONR.sup.9, or S(O).sub.n R.sup.12 ;aryl is phenyl or naphthyl, each optionally substituted with 1 to 3 substituents independently selected at each occurrence from C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.4 -C.sub.7 cycloalkylalkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl, halogen, C.sub.1 -C.sub.4 haloalkyl, cyano, --OR.sup.10, --SH, --S(O).sub.n R.sup.12, --COR.sup.12, --CO.sub.2 R.sup.8, --OC(O)R.sup.12, --NR.sup.9 COR.sup.9, --N(COR.sup.12).sub.2, --NR.sup.9 CONR.sup.9 R.sup.10, --NR.sup.9 CO.sub.2 R.sup.8, --NR.sup.9 R.sup.10, and --CONR.sup.9 R.sup.10 ;heteroaryl is pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl, triazinyl, furanyl, quinolinyl, isoquinolinyl, thienyl, imidazolyl, thiazolyl, indolyl, pyrrolyl, oxazolyl, benzofuranyl, benzothienyl, benzthiazolyl, isoxazolyl, pyrazolyl, triazolyl, tetrazolyl, or indazolyl, each optionally substituted with 1 to 3 substituents independently selected at each occurrence from C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.4 -C.sub.7 cycloalkylalkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl, halogen, C.sub.1 -C.sub.4 haloalkyl, cyano, --OR.sup.10, --SH, --S(O).sub.n R.sup.12, --COR.sup.12, --CO.sub.2 R.sup.8, --OC(O)R.sup.12, --NR.sup.9 COR.sup.9, --N(COR.sup.12).sub.2, --NR.sup.9 CONR.sup.9 R.sup.10, --NR.sup.9 CO.sub.2 R.sup.8, --NR.sup.9 R.sup.10, and --CONR.sup.9 R.sup.10 ;heterocyclyl is saturated or partially saturated heteroaryl, optionally substituted with 1 to 3 substituents independently selected at each occurrence from C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 -cycloalkyl, C.sub.4 -C.sub.7 cycloalkylalkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl, halogen, C.sub.1 -C.sub.4 haloalkyl, cyano, --OR.sup.10, SH, --S(O).sub.n R.sup.12, --COR.sup.12, --CO.sub.2 R.sup.12, --OC(O)R.sup.12, --NR.sup.9 COR.sup.9, --N(COR.sup.12).sub.2, --NR.sup.9 CONR.sup.9 R.sup.10, --NR.sup.9 CO.sub.2 R.sup.12, --NR.sup.9 R.sup.10, and --CONR.sup.9 R.sup.10 ;n is independently at each occurrence 0, 1 or 2;provided that:(a) when Q is I.sub.a, I.sub.b or I.sub.c and X is N, R.sup.1 is other than H and CH.sub.3 ;(b) R.sup.1 is other than O-alkynyl or S-alkynyl; and(c) when Q is I.sub.b, X is N, U is CR.sup.13 R.sup.14, and V is CR.sup.13 R.sup.14, then R.sup.1 is other than NR.sup.9 R.sup.10.