Bioadhesive progressive hydration tablets and methods of making and using the same
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-009/20
A61F-002/00
A61F-006/06
A61F-009/26
출원번호
US-0379310
(1999-08-23)
발명자
/ 주소
Bologna William J.,FRX
Levine Howard L.
Cartier Philippe,FRX
de Ziegler Dominique,FRX
출원인 / 주소
Columbia Laboratories, Inc.
대리인 / 주소
Lyon & Lyon LLP
인용정보
피인용 횟수 :
16인용 특허 :
35
초록▼
A bioadhesive tablet wherein the active ingredient may be protected from water or the surrounding environment, thereby protecting it from metabolism or from other degradation caused by moisture, enzymes, or pH effects, and making it bioavailable only at a controlled rate. The active ingredient may b
A bioadhesive tablet wherein the active ingredient may be protected from water or the surrounding environment, thereby protecting it from metabolism or from other degradation caused by moisture, enzymes, or pH effects, and making it bioavailable only at a controlled rate. The active ingredient may be protected from moisture during the manufacturing process and more importantly may be protected from moisture and the immediate septic environment until after the patient has applied the tablet, and then only at a slow and controlled rate. It is by this process of progressive hydration that the active ingredient remains protected for many hours after administration. It is also by the process of progressive hydration that controlled and sustained release is achieved because only that part of the active ingredient that is the hydrated (aqueous) fraction of the tablet is available for absorption (bioavailable).
대표청구항▼
[ What is claimed is:] [1.]1. A sustained release, progressive hydration bioadhesive tablet comprising:an effective amount of active ingredient selected from the group consisting of glycoproteins, proteins, sex hormones, anti-hormones, nitrates, beta-agonists, beta-antagonists, opioids, opioid-antag
[ What is claimed is:] [1.]1. A sustained release, progressive hydration bioadhesive tablet comprising:an effective amount of active ingredient selected from the group consisting of glycoproteins, proteins, sex hormones, anti-hormones, nitrates, beta-agonists, beta-antagonists, opioids, opioid-antagonists, antidepressants, HMG CoA reductase inhibitors, antihistamines, ACE inhibitors, prostagladins, and any other active ingredient which is metabolized or degraded by moisture, enzymes or pH,about 5% to about 50% by weight cellulose,about 0.5% to about 25% by weight starch,about 1% to about 50% by weight lactose,about 0.5% to about 10% by weight water insoluble cross-inked polycarboxylic polymer, andabout 1% to about 75% by weight water soluble polymer.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (35)
Pitha Josef (Baltimore MD), Administration of sex hormones in the form of hydrophilic cyclodextrin derivatives.
Cuca Robert C. (Edwardsville IL) Lienhop Keith S. (St. Charles MO) Riley ; Jr. Thomas C. (Ballwin MO) Levinson R. Saul (Chesterfield MO) Kirschner Mitchell I. (St. Louis MO), Bioadhesive pharmaceutical delivery system.
Britton Peter (1133 S. Martine Ave. Scotch Plains NJ 07076) Flanagan Patricia (765 S. River Rd. Naperville IL 60540) Hart William P. (47 Wellington Rd. Freehold NJ 07728) Linkin Deborah (315E Medalli, Bioerodible device for administering active ingredients.
Oettel Michael,DEX ; Golbs Siegfried,DEX ; Dittgen Michael,DEX ; Timpe Carsten,DEX ; Graser Thomas,DEX ; Hubler Doris,DEX, Compound preparation for the treatment of hypogonadal men and men with hypophyseal diseases.
El-Rashidy Ragab (Deerfield IL) Ronsen Bruce (River Forest IL) Hassan Emad E. (Sidi Gaber EGX), Controlled release of drugs delivered by sublingual or buccal administration.
Dumoulin Yves,CAX ; Carriere Fran.cedilla.ois,CAX ; Ingenito Andre,CAX, Manufacture of cross-linked amylose useful as a excipient for control release of active compounds.
Nagai Tsuneji (Chofu JPX) Machida Yoshiharu (Kawasaki JPX) Suzuki Yoshiki (Hino JPX) Ikura Hiroshi (Hino JPX), Method and preparation for administration to the mucosa of the oral or nasal cavity.
Britton Peter (1133 S. Martine Ave. Scotch Plains NJ 07076) Flanagan Patricia (765 S. River Rd. Naperville IL 60540) Hart William P. (47 Wellington Rd. Freehold NJ 07728) Linkin Deborah (315E Medalli, Method for manufacturing buccal delivery device.
Ebert Charles D. (Salt Lake City UT) Patel Dinesh C. (Murray UT) Mazer Norman A. (Salt Lake City UT) Venkateshwaran Srinivasan (Salt Lake City UT), Methods for providing testosterone and optionally estrogen replacement therapy to women.
Aiache Jean-Marc (17 rue Marchal Gallini 63000 Clermond-Ferrand FRX), Process for preparing a bioadhesive pharmaceutical dosage form and pharmaceutical dosage form thus prepared.
Schor Joseph M. (Locust Valley NY) Nigalaye Ashok (Jackson Heights NY) Gaylord Norman G. (New Providence NJ), Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose.
Amidon, Gregory Everett; Ganorkar, Loksidh Devi; Heimlich, John Mark; Lee, Ernest J.; Noack, Robert Martin; Reo, Joseph Peter; Skoug, Connie Jo, Sustained-release tablet composition of pramipexole.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.