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Method for gene therapy using nucleic acid loaded polymeric microparticles 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-048/00
  • C12N-015/11
출원번호 US-0675454 (1996-07-03)
발명자 / 주소
  • Mathiowitz Edith
  • Jong Yong S.
  • Carino Gerardo
  • Jacob Jules S.
출원인 / 주소
  • Brown University Research Foundation
대리인 / 주소
    Wolf, Greenfield & Sacks. P.C.
인용정보 피인용 횟수 : 33  인용 특허 : 20

초록

The invention involves methods and products for oral gene therapy. Genes under the control of promoters are protectively contained in microparticles and delivered to cells in operative form, thereby obtaining noninvasive gene delivery for gene therapy.

대표청구항 ▼

[ What we claim is:] [1.]1. A method for delivery of a gene under the control of a promoter to a cell of a subject, comprising:administering to a mucosal epithelial surface of a subject an effective amount of bioadhesive microparticles containing an intact vector comprising a gene under the control

이 특허에 인용된 특허 (20)

  1. Domb Abraham J. (Baltimore MD), Aromatic polyanhydride compositions.
    상세보기
  2. Grinstaff Mark W. (Pasadena CA) Soon-Shiong Patrick (Los Angeles CA) Wong Michael (Champaign IL) Sandford Paul A. (Los Angeles CA) Suslick Kenneth S. (Champaign IL) Desai Neil P. (Los Angeles CA), Composition useful for in vivo delivery of biologics and methods employing same.
    상세보기
  3. Kuehnle Adelheid R. (1617 Keeaumoku St. #1008 Honolulu HI 96822) Kuehnle Manfred R. (Waldesruh Rte. 103A ; P.O. Box 1020 New London NH 03257), Magnetophoretic particle delivery method and apparatus for the treatment of cells.
    상세보기
  4. Fitzpatrick-McElligott Sandra G. (Media PA) Lavin John G. (Swarthmore PA) Rivard Germain F. (Philadelphia PA) Subramoney Shekhar (Hockessin DE), Method for introducing a biological substance into a target.
    상세보기
  5. Sanford John C. (Geneva NY) Wolf Edward D. (Ithaca NY) Allen Nelson K. (Newfield NY), Method for transporting substances into living cells and tissues and apparatus therefor.
    상세보기
  6. Tice Thomas R. (Birmingham AL) Gilley Richard M. (Birmingham AL) Eldridge John H. (Birmingham AL) Staas Jay K. (Birmingham AL) Hollingshead Melinda G. (Birmingham AL) Shannon William M. (Birmingham A, Method of potentiating an immune response.
    상세보기
  7. Grinstaff Mark W. (Pasadena CA) Soon-Shiong Patrick (Los Angeles CA) Wong Michael (Champaign IL) Sandford Paul A. (Los Angeles CA) Suslick Kenneth S. (Champaign IL) Desai Neil P. (Los Angeles CA), Methods for the preparation of nucleic acids for in vivo delivery.
    상세보기
  8. Tice Thomas R. (Birmingham AL) Gilley Richard M. (Birmingham AL), Microencapsulation process and products therefrom.
    상세보기
  9. Chang James N. (Irvine CA), Monolithic maleic anhydride drug delivery systems.
    상세보기
  10. Meadows David L. (Mission Viejo CA), Nonaqueous fluorinated drug delivery vehicle suspensions.
    상세보기
  11. Meadows David L. (Mission Viejo CA), Nonaqueous thixotropic drug delivery suspensions and methods of their use.
    상세보기
  12. Landh Tomas (Lund SEX) Larsson Kare (Bjrred SEX), Particles, method of preparing said particles and uses thereof.
    상세보기
  13. Boyes Robert N. (St. Albans AL GB2) Tice Thomas R. (Birmingham AL) Gilley Richard M. (Birmingham AL) Pledger Kenneth L. (Huntsville AL), Pharmaceutical formulations comprising microcapsules.
    상세보기
  14. McGinity James W. (Austin TX) Iwata Motokazu (Osaka JPX), Preparation and uses of multi-phase microspheres.
    상세보기
  15. Morishita Masataka (Shizuoka JA) Inaba Yoshihito (Shizuoka JA) Fukushima Mitsuru (Shizuoka JA) Kobari Sadami (Shizuoka JA) Nagata Akiho (Shizuoka JA) Abe Jinnosuke (Shizuoka JA), Preparation of microcapsules.
    상세보기
  16. Mathiowitz Edith (Brookline MA) Langer Robert S. (Somerville MA), Preparation of multiwall polymeric microcapsules.
    상세보기
  17. Devissaguet Jean-Philippe (Neuilly sur Seine FRX) Fessi Hatem (Paris FRX) Puisieux Francis (Maisons Alfort FRX), Process for the preparaton of dispersible colloidal systems of a substance in the form of nanocapsules.
    상세보기
  18. Gardner David L. (Bellville OH), Process of preparing microcapsules of lactides or lactide copolymers with glycolides and/or e 상세보기
  • Samulski Richard J. (Pittsburgh PA) Xiao Xiao (Pittsburgh PA), Recombinant viral vector system.
    상세보기
  • Kossovsky Nir (Los Angeles CA) Hnatyszyn H. James (Los Angeles CA) Gelman Andrew (Los Angeles CA), Targeted transfection nanoparticles.
    상세보기

    • 이 특허를 인용한 특허 (33)

    1. German, Michael; Goldfine, Ira D.; Rothman, Stephen S., Delivery of therapeutic gene products by intestinal cell expression.
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    2. Monia, Brett P.; Freier, Susan M.; Siwkowski, Andrew M.; Guo, Shuling, Diagnosis and treatment of disease.
      상세보기
    3. Tuszynski,Jack; Woolf,Nancy J., Drug delivery apparatus utilizing cantilever.
      상세보기
    4. Tarara, Thomas E.; Weers, Jeffry G.; Kabalnov, Alexey; Schutt, Ernest G.; Dellamary, Luis A., Engineered particles and methods of use.
      상세보기
    5. Tarara, Thomas E.; Weers, Jeffry G.; Eldon, Michael A.; Narashimhan, Rangachari; Clark, Andrew, Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use.
      상세보기
    6. Krieg, Arthur M.; Klinman, Dennis; Steinberg, Alfred D., Immunomodulatory oligonucleotides.
      상세보기
    7. Krieg, Arthur M.; Klinman, Dennis; Steinberg, Alfred D., Immunomodulatory oligonucleotides.
      상세보기
    8. Krieg, Arthur M.; Kline, Joel; Klinman, Dennis; Steinberg, Alfred D., Immunostimulatory nucleic acid molecules.
      상세보기
    9. Krieg, Arthur M.; Klinman, Dennis; Steinberg, Alfred D., Immunostimulatory nucleic acid molecules.
      상세보기
    10. Mathiowitz, Edith; Jong, Yong S.; Carino, Gerardo; Jacob, Jules S., Method for gene therapy using nucleic acid loaded polymeric microparticles.
      상세보기
    11. Davis,Heather L.; Schorr,Joachim; Krieg,Arthur M., Method of inducing an antigen-specific immune response by administering a synergistic combination of adjuvants comprising unmethylated CpG-containing nucleic acids and a non-nucleic acid adjuvant.
      상세보기
    12. McCluskie, Michael J.; Davis, Heather L., Methods and products for inducing mucosal immunity.
      상세보기
    13. Mathiowitz, Edith; Thanos, Christopher; Liu, Zhi, Methods for micronization of hydrophobic drugs.
      상세보기
    14. Mathiowitz, Edith; Thanos, Christopher; Liu, Zhi, Methods for micronization of hydrophobic drugs.
      상세보기
    15. Mathiowitz, Edith; Thanos, Christopher; Liu, Zhi, Methods for micronization of hydrophobic drugs.
      상세보기
    16. Jones, David Hugh; Farrar, Graham Henry; Clegg, James Christopher Stephen, Microencapsulated DNA for vaccination and gene therapy.
      상세보기
    17. Naimark, Wendy; Palasis, Maria, Microparticle protection of therapeutic agents.
      상세보기
    18. Freier, Susan M., Modulation of transthyretin expression.
      상세보기
    19. Monia, Brett P.; Freier, Susan M.; Siwkowski, Andrew M.; Guo, Shuling, Modulation of transthyretin expression.
      상세보기
    20. Golomb, Gershon; Sacks, Haigt; Najareh, Yousef; Fishbein, Elia; Chorny, Michael, Nanoparticles containing polymeric nucleic acid homologs.
      상세보기
    21. Weers, Jeffry G.; Tarara, Thomas E.; Dellamary, Luis A.; Riess, Jean G.; Schutt, Ernest G., Phospholipid-based powders for drug delivery.
      상세보기
    22. Weers, Jeffry G; Tarara, Thomas E; Dellamary, Luis A; Riess, Jean G; Schutt, Ernest G, Phospholipid-based powders for drug delivery.
      상세보기
    23. Mathiowitz, Edith; Chickering, III, Donald; Jong, Yong S.; Jacob, Jules S., Process for preparing microparticles through phase inversion phenomena.
      상세보기
    24. Tarara, Thomas E.; Weers, Jeffry G.; Venthoye, Geraldine, Pulmonary delivery of aminoglycoside.
      상세보기
    25. Tarara, Thomas E; Weers, Jeffry G; Venthoye, Maria Geraldine, Pulmonary delivery of aminoglycoside.
      상세보기
    26. Tarara, Thomas E.; Weers, Jeffrey G.; Kabalnov, Alexey; Schutt, Ernest G.; Dellamary, Luis A., Pulmonary delivery particles comprising an active agent.
      상세보기
    27. Weinbach, Susan; Tillman, Lloyd G.; Geary, Richard S.; Hardee, Gregory E., Pulsatile release compositions and methods for enhanced intestinal oligonucleotide drug absorption.
      상세보기
    28. Weers, Jeffry G.; Schutt, Ernest G.; Dellamary, Luis A.; Tarara, Thomas E.; Kabalnov, Alexey, Respiratory dispersion for metered dose inhalers comprising perforated microstructures.
      상세보기
    29. Rozema, David B.; Wakefield, Darren; Wolff, Jon A; Ekena, Kirk; Hagstrom, James E., Reversible attachment of a membrane active polymer to a polynucleotide.
      상세보기
    30. Dellamary, Luis A.; Reiss, Jean; Schutt, Ernest G.; Weers, Jeffry G.; Tarara, Thomas E., Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery.
      상세보기
    31. Dellamary, Luis A.; Riess, Jean; Schutt, Ernest G.; Weers, Jeffry G.; Tarara, Thomas E., Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use.
      상세보기
    32. Dellamary, Luis A; Riess, Jean; Schutt, Ernest G; Weers, Jeffry G; Tarara, Thomas E, Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use.
      상세보기
    33. Sabel,Bernhard; Walz,Christian; Ringe,Kerstin, Use of nanoparticles for the DNA administration to a target organ.
      상세보기

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