초록 ▼

Disclosed are methods and materials for visualizing or treating vasculature. The methods and materials in this invention relate to selective and non-invasive visualization, or treatment such as chemical occlusion, of vasculature in the mammalian eye. The methods utilize fluorescent dyes and tissue-r

Disclosed are methods and materials for visualizing or treating vasculature. The methods and materials in this invention relate to selective and non-invasive visualization, or treatment such as chemical occlusion, of vasculature in the mammalian eye. The methods utilize fluorescent dyes and tissue-reactive substances encapsulated within heat-sensitive liposomes which are subsequently heated to release the contents thereof at a pre-determined anatomical locus. The methods of this invention further utilize tissue-reactive agents which, when activated, are effective to cause localized tissue damage and occlusion of blood vessels and/or blood sinuses. The materials of this invention relate to diagnostic reagents and kits for visualizing or treating a mammalian blood vessel or sinus.

대표청구항 ▼

[ What is claimed is:] [1.]1. A diagnostic reagent for visualizing and chemically occluding a blood vessel or blood sinus in a mammal, comprising:(a) a fluorescent dye encapsulated within a heat-sensitive liposome, the fluorescent dye being releasable from the heat-sensitive liposome at about 41.deg

[ What is claimed is:] [1.]1. A diagnostic reagent for visualizing and chemically occluding a blood vessel or blood sinus in a mammal, comprising:(a) a fluorescent dye encapsulated within a heat-sensitive liposome, the fluorescent dye being releasable from the heat-sensitive liposome at about 41.degree. C. or less;(b) a tissue-reactive agent effective upon activation to cause chemical damage to tissue; and,(c) a pharmaceutically-acceptable vehicle, wherein said reagent is suitable for systemic administration to said mamnmal.