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Administration of ketamine to manage pain and to reduce drug dependency 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-031/135
출원번호 US-0029146 (1998-02-27)
국제출원번호 PCT/US96/14095 (1996-08-29)
§371/§102 date 19980227 (19980227)
국제공개번호 WO-9707750 (1997-03-06)
발명자 / 주소
  • Weg Stuart L.
대리인 / 주소
    Darby & Darby
인용정보 피인용 횟수 : 32  인용 특허 : 16

초록

The present invention is directed to the transmucosal, transdermal or oral administration of ketamine, either alone or in combination with other pain medications, to manage and treat pain and to reduce drug dependency in a subject.

대표청구항

[ What is claimed is:] [1.]1. A method for treating pain in a subject comprising incrementally administering transmucosally a dose of about 0.01 mg/kg of body weight to about 1 mg/kg of ketamine effective to alleviate pain in a subject suffering from pain while avoiding dysphoria.

이 특허에 인용된 특허 (16)

  1. Klose ; deceased Volker (late of Straubing DEX by Gabriele Klose ; heir), Ball-game racket, particularly a tennis racket.
    상세보기
  2. Stanley Theodore H. (Salt Lake City UT) Hague Brian (West Valley City UT), Compositions and methods of manufacture of compressed powder medicaments.
    상세보기
  3. Fallon Renee A. (Sunnyvale CA) Wilson Donald R. (San Francisco CA), Device for administering drug transdermally which provides an initial pulse of drug.
    상세보기
  4. Sibalis Dan (Stony Brook NY), Electrical transdermal drug applicator with counteractor and method of drug delivery.
    상세보기
  5. Hamacher Edward N. (Suite 660 ; Southcenter Medical Bldg. ; West 105 ; 8th Ave. Spokane WA 99204), Method for administering a dissociative, unconscious type of anesthesia.
    상세보기
  6. Stanley Theodore H. (Salt Lake City UT) Haque Brian (West Valley City UT), Methods and compositions for noninvasive administration of sedatives, analgesics, and anesthetics.
    상세보기
  7. Wilfong Debra L. (Lake Elmo MN) Rolando Richard J. (Oakdale MN), Multilayered barrier structures.
    상세보기
  8. Tucker Mark J. (Round Steps ; High Street Stow-on-the-Wold ; Gloucester GL54 1DL GBX) Tucker Mark R. (P.O. Box 23530 Bahrain BHX), Occlusive body for administering a physiologically active substance.
    상세보기
  9. Kowarski Hanna R. (Pikesville MD), Pharmaceutical composition and method of intranasal administration.
    상세보기
  10. Sibalis Dan (Stony Brook NY), Pulsating transdermal drug delivery system.
    상세보기
  11. Farhadieh Bahram (Libertyville IL) Gokhale Rajeev D. (Vernon Hills IL), Single layer transdermal drug administration system.
    상세보기
  12. Farhadieh Bahram (Libertyville IL) Gokhale Rajeev D. (Vernon Hills IL) Berger Hana (Lincolnshire IL) Vallner Joseph (Mountainview CA), Single layer transdermal drug administration system.
    상세보기
  13. Benecke Arnold G. (Hamilton OH) Kinne Daniel J. (Cincinnati OH) Wnuk Andrew J. (Wyoming OH), Storage-stable transdermal patch.
    상세보기
  14. Sibalis Dan (Stony Brook NY), Transdermal drug delivery system.
    상세보기
  15. Sibalis Dan (Stony Brook NY), Transdermal drug patch with conductive fibers.
    상세보기
  16. Sibalis Dan (Stony Brook NY), Transdermal drug patch with microtubes.
    상세보기

이 특허를 인용한 특허 (32)

  1. Tzannis, Stelios; Hamel, Larry; Palmer, Pamela; Schreck, Thomas; Poutiatine, Andrew I., Bioadhesive drug formulations for oral transmucosal delivery.
    상세보기
  2. Tzannis, Stelios; Hamel, Larry; Palmer, Pamela; Schreck, Thomas; Poutiatine, Andrew I., Bioadhesive drug formulations for oral transmucosal delivery.
    상세보기
  3. Tzannis, Stelios; Palmer, Pamela; Schreck, Thomas; Hamel, Larry; Poutiatine, Andrew I., Bioadhesive drug formulations for oral transmucosal delivery.
    상세보기
  4. Ray, II, Jay Richard, Composition and method for compounded therapy.
    상세보기
  5. Ray, II, Jay Richard; Hodge, Charles D., Composition and method for compounded therapy.
    상세보기
  6. Ray, II, Jay Richard; Hodge, Charles D., Composition and method for compounded therapy.
    상세보기
  7. Ray, II, Jay Richard; Hodge, Charles D., Compounded transdermal pain management.
    상세보기
  8. Zhang,Hao, Dissolvable backing layer for use with a transmucosal delivery device.
    상세보기
  9. Zhang,Hao, Dissolvable backing layer for use with a transmucosal delivery device.
    상세보기
  10. Poutiatine, Andrew I.; Rampersaud, Charles; Schreck, Thomas; Kolosi, William; Retailleau, Sascha, Drug dispensing device with flexible push rod.
    상세보기
  11. Poutiatine, Andrew I.; Rampersaud, Charles; Schreck, Thomas; Kolosi, William; Retailleau, Sascha, Drug storage and dispensing devices and systems comprising the same.
    상세보기
  12. Friedman, Robert, Ketamine treatment of restless legs syndrome.
    상세보기
  13. Palmer, Pamela; Poutiatine, Andrew I.; Rampersaud, Charles; Edwards, Bruce; Chiu, Edmond; Schreck, Thomas; Tzannis, Stelios; Hamel, Larry, Method of moving a delivery member of a dispensing device for administration of oral transmucosal dosage forms.
    상세보기
  14. Palmer, Pamela; Poutiatine, Andrew; Rampersaud, Charles; Edwards, Bruce; Chiu, Edmond; Schreck, Thomas; Tzannis, Stelios; Hamel, Lawrence; Kolosi, William; Retailleau, Sascha, Methods and apparatus for administering small volume oral transmucosal dosage forms.
    상세보기
  15. Palmer, Pamela; Poutiatine, Andrew I; Rampersaud, Charles; Edwards, Bruce; Chiu, Edmond; Schreck, Thomas; Tzannis, Stelios; Hamel, Larry, Methods for administering small volume oral transmucosal dosage forms using a dispensing device.
    상세보기
  16. Palmer, Pamela; Poutiatine, Andrew; Rampersaud, Charles; Edwards, Bruce; Chiu, Edmond; Schreck, Thomas; Tzannis, Stelios; Hamel, Lawrence; Kolosi, William; Retailleau, Sascha, Methods for administering small volume oral transmucosal dosage forms using a dispensing device.
    상세보기
  17. Mermelstein,Fred H.; Albin,Randi, NMDA receptor antagonist formulation with reduced neurotoxicity.
    상세보기
  18. Kao, Haui-Hung; Baichwal, Anand R.; McCall, Troy; Lee, David, Oxymorphone controlled release formulations.
    상세보기
  19. Kao, Huai-Hung; Baichwal, Anand R.; McCall, Troy; Lee, David, Oxymorphone controlled release formulations.
    상세보기
  20. Schiene, Klaus; Bloms-Funke, Petra, Pharmaceutical combination.
    상세보기
  21. Palmer, Pamela; Schreck, Thomas; Hamel, Lawrence; Tzannis, Stelio; Poutiatine, Andrew, Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain.
    상세보기
  22. Palmer, Pamela; Schreck, Thomas; Tzannis, Stelios; Hamel, Larry; Poutiatine, Andrew I., Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain.
    상세보기
  23. Palmer, Pamela; Schreck, Thomas; Tzannis, Stelios; Hamel, Larry; Poutiatine, Andrew I., Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain.
    상세보기
  24. Palmer, Pamela; Schreck, Thomas; Tzannis, Stelios; Hamel, Larry; Poutiatine, Andrew I., Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain.
    상세보기
  25. Palmer, Pamela; Schreck, Thomas; Tzannis, Stelios; Hamel, Larry; Poutiatine, Andrew I.; Rampersaud, Charles; Edwards, Bruce, Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain.
    상세보기
  26. Palmer, Pamela; Schreck, Thomas; Tzannis, Stelios; Hamel, Larry; Poutiatine, Andrew I.; Rampersaud, Charles; Edwards, Bruce, Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain.
    상세보기
  27. Palmer, Pamela; Schreck, Thomas; Tzannis, Stelios; Hamel, Larry; Poutiatine, Andrew I., Small-volume oral transmucosal dosage.
    상세보기
  28. Palmer, Pamela; Schreck, Thomas; Tzannis, Stelios; Hamel, Larry; Poutiatine, Andrew I., Small-volume oral transmucosal dosage forms.
    상세보기
  29. Poutiatine, Andrew I.; Rampersaud, Charles; Edwards, Bruce; Chiu, Edmond; Tzannis, Stelios; Palmer, Pamela; Kolosi, William; Retailleau, Sascha, Storage and dispensing devices for administration of oral transmucosal dosage forms.
    상세보기
  30. Pushpala, Shamim; Hamel, Larry; Tzannis, Stelios; Cruz, Evangeline, Sufentanil solid dosage forms comprising oxygen scavengers and methods of using the same.
    상세보기
  31. Baichwal,Anand R.; Kao,Huai Hung; McCall,Troy W., Sustained release formulations of oxymorphone.
    상세보기
  32. Wolicki, Richard; Kim, Stanley, Topical formulations for treatment of neuropathy.
    상세보기

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