초록 ▼

Disclosed are 1) osteogenic devices comprising a matrix containing osteogenic protein and methods of inducing endochondral bone growth in mammals using the devices; 2) amino acid sequence data, amino acid composition, solubility properties, structural features, homologies and various other data char

Disclosed are 1) osteogenic devices comprising a matrix containing osteogenic protein and methods of inducing endochondral bone growth in mammals using the devices; 2) amino acid sequence data, amino acid composition, solubility properties, structural features, homologies and various other data characterizing osteogenic proteins, 3) methods of producing osteogenic proteins using recombinant DNA technology, and 4) osteogenically and chondrogenically active synthetic protein constructs.

대표청구항 ▼

[ What is claimed is:] [1.]1. A vector comprising the DNA sequence:(a) CTGTATGTCAGCTTCCGAGACCTGGGCTGGCAGGACTGGATCATCGCGCC TGAAGGCTACGCGCGCTACTACTGTGAGGGGGAGTGTGCCTTCCCTCTGA ACTCCTACATGAACGCCACCAACCACGCCATCGTGCAGACGCTGGTCCAC TTCATCAACCCGGAAACGGTGCCCAAGCCCTGCTGTGCGCCCACGCAGCT CAATGCCATCTCCGTCCTCTACTTC

[ What is claimed is:] [1.]1. A vector comprising the DNA sequence:(a) CTGTATGTCAGCTTCCGAGACCTGGGCTGGCAGGACTGGATCATCGCGCC TGAAGGCTACGCGCGCTACTACTGTGAGGGGGAGTGTGCCTTCCCTCTGA ACTCCTACATGAACGCCACCAACCACGCCATCGTGCAGACGCTGGTCCAC TTCATCAACCCGGAAACGGTGCCCAAGCCCTGCTGTGCGCCCACGCAGCT CAATGCCATCTCCGTCCTCTACTTCGATGACAGCTCCAACGTCATCCTGAA GAAATACAGAAACATGGTGGTCCGGGCCTGTGGCTGCCACTAGCTCCT, or(b) encoding an amino acid sequence: LYVSFRDLGWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHFI NPETVPKPCCAPTOLNAISVLYFDDSSNVILKKYRNMVVRACGCH, or a conservative amino acid variant thereof,wherein said DNA sequence encodes a protein competent to induce bone and cartilage in a mammal.