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Stable protein and nucleic acid formulations using non-aqueous, anhydrous, aprotic, hydrophobic, non-polar vehicles with low reactivity. 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-009/50
  • A61K-009/14
  • A61K-038/00
출원번호 US-0269685 (1999-12-14)
국제출원번호 PCT/US97/18575 (1997-10-15)
§371/§102 date 19991214 (19991214)
국제공개번호 WO-9816250 (1998-04-23)
발명자 / 주소
  • Knepp Victoria Marie
  • Prestrelski Steven Joseph
  • Smith Jessica G.
  • Huang Manley T.
출원인 / 주소
  • ALZA Corporation
대리인 / 주소
    Clarke
인용정보 피인용 횟수 : 42  인용 특허 : 2

초록 ▼

This invention relates to stable non-aqueous formulations which are suspensions of proteinaceous substances or nucleic acids in non-aqueous, anhydrous, aprotic, hydrophobic, non-polar vehicles with low reactivity. More specifically, the present invention relates to stable protein or nucleic acid for

대표청구항 ▼

[ What is claimed is:] [1.]1. A stable non-aqueous composition of a biologically active agent comprising:a) a biologically active agent containing powder wherein the biologically active agent hydration in said powder is less than 10%; andb) at least one anhydrous, aprotic, hydrophobic, non-polar, lo

이 특허에 인용된 특허 (2)

  1. Meadows David L. (Mission Viejo CA), Nonaqueous fluorinated drug delivery vehicle suspensions.
    상세보기
  2. Meadows David L. (Mission Viejo CA), Nonaqueous thixotropic drug delivery suspensions and methods of their use.
    상세보기

이 특허를 인용한 특허 (42)

  1. Foldvari, Marianna; Kumar, Praveen; Docherty, John M., Biphasic lipid-vesicle compositions.
    상세보기
  2. Kumar, Praveen, Biphasic lipid-vesicle compositions and methods for treating cervical dysplasia by intravaginal delivery.
    상세보기
  3. Kumar, Praveen, Biphasic lipid-vesicle compositions and methods for treating cervical dysplasia by intravaginal delivery.
    상세보기
  4. Kumar, Praveen, Biphasic lipid-vesicle compositions and methods for treating cervical dysplasia by intravaginal delivery.
    상세보기
  5. Kumar, Praveen, Biphasic lipid-vesicle compositions and methods for treating cervical dysplasia by intravaginal delivery.
    상세보기
  6. Prestrelski, Steven J., Compositions for rapidly treating severe hypoglycemia.
    상세보기
  7. Uhland, Scott A.; Polito, Benjamin F.; Maloney, John M.; Sheppard, Jr., Norman F.; Herman, Stephen J.; Yomtov, Barry M., Containment device with multi-layer reservoir cap structure.
    상세보기
  8. Prescott,James H.; Kreiger,Timothy; Proos,Elizabeth R., Control of drug release by transient modification of local microenvironments.
    상세보기
  9. Uhland,Scott A.; Polito,Benjamin F.; Maloney,John M.; Sheppard, Jr.,Norman F.; Herman,Stephen J.; Yomtov,Barry Y., Controlled release device and method using electrothermal ablation.
    상세보기
  10. Prestrelski, Steven, Formulations for the treatment of diabetes.
    상세보기
  11. Uhland,Scott A.; Polito,Benjamin F.; Herman,Stephen J.; Santini, Jr.,John T.; Maloney,John M., Hermetically sealed microchip reservoir devices.
    상세보기
  12. Ausiello, Dennis; Santini, Jr., John T.; Herman, Stephen J.; Prescott, James H.; Uhland, Scott A.; Maloney, John M.; Polito, Benjamin F., Implantable device for controlled, extended delivery of parathyroid hormone.
    상세보기
  13. Prestrelski, Steven; Brodbeck, Kevin, Intracutaneous injection.
    상세보기
  14. Prestrelski, Steven; Brodbeck, Kevin, Intracutaneous paste composition.
    상세보기
  15. Santini, Jr., John T.; Herman, Stephen J., Medical device for sensing glucose.
    상세보기
  16. Ausiello,Dennis; Santini, Jr.,John T.; Herman,Stephen J.; Prescott,James H.; Uhland,Scott A.; Maloney,John M.; Polito,Benjamin F., Method and device for the controlled delivery of parathyroid hormone.
    상세보기
  17. Prestrelski, Steven; Sandoval, Michael; Donovan, Martin, Methods for producing stable therapeutic formulations in aprotic polar solvents.
    상세보기
  18. Prestrelski, Steven J., Methods for rapidly treating severe hypoglycemia.
    상세보기
  19. Johnson,Audrey M.; Cima,Michael J.; Langer,Robert S., Microscale lyophilization and drying methods for the stabilization of molecules.
    상세보기
  20. Santini, Jr., John T.; Sbiaa, Zouhair; Coppeta, Jonathan R.; Uhland, Scott A.; Sheppard, Jr., Norman F., Multi-cap reservoir devices for controlled release or exposure of reservoir contents.
    상세보기
  21. Santini, Jr., John T.; Sbiaa, Zouhair; Coppeta, Jonathan R.; Uhland, Scott A.; Sheppard, Jr., Norman F., Multi-opening reservoir devices for controlled release or exposure of reservoir contents.
    상세보기
  22. Santini, Jr., John T.; Staples, Mark A.; Herman, Stephen J., Multi-reservoir device for transdermal drug delivery and sensing.
    상세보기
  23. Lively, Chris Robert; DeLong, Robert, Nucleic acid coated particles suitable for temporary storage.
    상세보기
  24. Prestrelski, Steven; Brodbeck, Kevin, Pastes for injection of a therapeutic agent.
    상세보기
  25. Prestrelski, Steven; Kinzell, John, Stable formulations for parenteral injection of peptide drugs.
    상세보기
  26. Prestrelski, Steven; Kinzell, John, Stable formulations for parenteral injection of peptide drugs.
    상세보기
  27. Prestrelski, Steven; Kinzell, John, Stable formulations for parenteral injection of peptide drugs.
    상세보기
  28. Prestrelski, Steven; Kinzell, John, Stable formulations for parenteral injection of peptide drugs.
    상세보기
  29. Prestrelski, Steven J.; Scott, Nancy, Stable formulations for parenteral injection of small molecule drugs.
    상세보기
  30. Prestrelski, Steven; Fang, Wei-Jie; Carpenter, John F.; Kinzell, John, Stable glucagon formulations for the treatment of hypoglycemia.
    상세보기
  31. Maskiewicz, Victoria Knepp; Prestrelski, Steven Joseph; Smith, Jessica G.; Huang, Manley T., Stable protein and nucleic acid formulations using non-aqueous, anhydrous, aprotic, hydrophobic, non-polar vehicles with low reactivity.
    상세보기
  32. Liu, Kui; Desjardin, Michael A.; Hill, Beth L.; Li, Zengji, Stable suspension formulations of erythropoietin receptor agonists.
    상세보기
  33. Maskiewicz, Richard, Sublimable sustained release delivery system and method of making same.
    상세보기
  34. Maskiewicz, Richard, Sublimable sustained release delivery system and method of making same.
    상세보기
  35. Becker, Cyrus K.; Pfister, Jürg R.; Rescourio, Gwenaella; Venkatraman, Meenakshi S.; Zhang, Xiaoming, Treprostinil derivative compounds and methods of using same.
    상세보기
  36. Becker, Cyrus K.; Pfister, Jürg R.; Rescourio, Gwenaella; Venkatraman, Meenakshi S.; Zhang, Xiaoming, Treprostinil derivative compounds and methods of using same.
    상세보기
  37. Becker, Cyrus K.; Pfister, Jürg R.; Rescourio, Gwenaella; Venkatraman, Meenakshi S.; Zhang, Xiaoming, Treprostinil derivative compounds and methods of using same.
    상세보기
  38. Becker, Cyrus K.; Venkatraman, Meenakshi S.; Zhang, Xiaoming, Treprostinil derivative compounds and methods of using same.
    상세보기
  39. Zhang, Xiaoming; Venkatraman, Meenakshi S.; Becker, Cyrus K., Treprostinil derivatives and compositions and uses thereof.
    상세보기
  40. Zhang, Xiaoming; Venkatraman, Meenakshi S.; Becker, Cyrus K., Treprostinil derivatives and compositions and uses thereof.
    상세보기
  41. Zhang, Xiaoming; Venkatraman, Meenakshi S.; Becker, Cyrus K., Treprostinil derivatives and compositions and uses thereof.
    상세보기
  42. Zhang, Xiaoming; Venkatraman, Meenakshi S.; Becker, Cyrus K., Treprostinil derivatives and compositions and uses thereof.
    상세보기

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