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Compositions containing thrombin and microfibrillar collagen and methods for preparation and use thereof 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-038/00
출원번호 US-0436903 (1999-11-09)
발명자 / 주소
  • Prior Jeffrey J.
  • Wallace Donald G.
  • Sierra David H.
  • DeLustro Frank A.
출원인 / 주소
  • Cohesion Technologies, Inc.
대리인 / 주소
    Morrison & Foerster
인용정보 피인용 횟수 : 48  인용 특허 : 23

초록 ▼

The present invention relates to thrombin-containing hemostatic compositions, their preparation and use. In particular, it relates to hemostatic compositions comprising stabilized thrombin and microfibrillar collagen in an aqueous medium. In a preferred embodiment of the present invention, the compo

대표청구항

[ What is claimed is:] [1.]1. A hemostatic composition comprising thrombin and microfibrillar collagen in an aqueous medium, wherein the microfibrillar collagen has an average diameter of about 3-30 nm.

이 특허에 인용된 특허 (23)

  1. Redl Heinz (Vienna ATX) Kriwetz Gert (Graz ATX), Apparatus for applying a tissue adhesive on the basis of human or animal proteins.
    상세보기
  2. Dunn Richard L. (Fort Collins CO) Tipton Arthur J. (Fort Collins CO) Southard George L. (Fort Collins CO) Rogers Jack A. (Fort Collins CO), Biodegradable system for regenerating the periodontium.
    상세보기
  3. Capozzi Emil E. (Costa Mesa CA) Cooksten H. Stephen (Malibu CA), Biological syringe system.
    상세보기
  4. Sanderson John E. (North Miami FL), Bone replacement and repair putty material from unsaturated polyester resin and vinyl pyrrolidone.
    상세보기
  5. Miyata Teruo (Tokyo NJ JPX) Stenzel Kurt H. (Englewood NJ) Rubin Albert L. (Englewood NJ), Chemically and enzymatically modified collagen hemostatic agent.
    상세보기
  6. Kato Tadaaki (Tokyo JPX), Collagen fibers for use in medical treatments.
    상세보기
  7. Cioca Gheorghe (Coatesville PA), Collagen-thrombin compositions.
    상세보기
  8. Prior Jeffrey J. ; Wallace Donald G. ; Sierra David H. ; DeLustro Frank A., Compositions containing thrombin and microfibrillar nanometer collagen, and methods for preparation and use thereof.
    상세보기
  9. Miller Curtis H. (Burnsville MN) Arenberg I. Kaufman (Englewood CO) Altshuler John H. (Englewood CO), Fibrin glue delivery system.
    상세보기
  10. Whalen Robert L. (Somerville MA) Dempsey Donald (Newbury MA), Fibrin monomer based tissue adhesive.
    상세보기
  11. Morse Brenda S. (Chamblee GA) Turner A. Denise (Dunwoody GA) McNally Robert T. (Marietta GA), Fibrin sealant delivery kit.
    상세보기
  12. Morse Brenda S. (Chamblee GA) Turner A. Denise (Dunwoody GA) McNally Robert T. (Marietta GA), Fibrin sealant delivery method.
    상세보기
  13. Saferstein Lowell (Edison NJ) Wolf Stephen J. (Manville NJ), Hemostatic collagen paste composition.
    상세보기
  14. Edgington Thomas S. (La Jolla CA) Morrissey James H. (San Diego CA), Human tissue factor related DNA segments.
    상세보기
  15. Porter Ned A. (Durham NC) Bruhnke John D. (Durham NC), Light activated acyl-enzymes.
    상세보기
  16. Epstein Gordon H. (135 Kootenai Dr. Fremont CA 94539), Method and apparatus for preparing fibrinogen adhesive from whole blood.
    상세보기
  17. Epstein Gordon H. (135 Kootenai Dr. Fremont CA 94539), Method for preparing fibrinogen adhesive from whole blood.
    상세보기
  18. Shenoy Vivek N. (Sunnyvale CA) Revak Timothy T. (Los Altos CA) Chu George H. (Cupertino CA) McMullin Hugh R. (Menlo Park CA) Rosenblatt Joel S. (Palo Alto CA) Martin George R. (Bethesda MD), Method of controlling structure stability of collagen fibers produced form solutions or dispersions treated with sodium.
    상세보기
  19. Holly Richard D. (Seattle WA) Foster Donald C. (Seattle WA), Methods for producing thrombin.
    상세보기
  20. Heimburger Norbert (Marburg DEX) Fuhge Peter (Lahntal DEX) Ronneberger Hansjrg (Marburg DEX), One-component tissue adhesive and a process for the production thereof.
    상세보기
  21. Altshuler John H. (Englewood CO), Ready-to-use bandage incorporating a coagulant composition and method of preparing same.
    상세보기
  22. Sierra David H. (San Jose CA) Luck Edward E. (Menlo Park CA) Brown Dennis M. (Menlo Park CA), Surgical adhesive material.
    상세보기
  23. Wadstrom Jonas (Dag Hammarskjolds vag 281 S-756 52 Uppsala SEX), Tissue treatment composition comprising fibrin or fibrinogen and biodegradable and biocompatible polymer.
    상세보기

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  1. El-Siblani, Ali, Apparatus and method for forming three-dimensional objects from solidifiable paste.
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  2. El-Siblani, Ali, Apparatus and method for forming three-dimensional objects from solidifiable paste.
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  3. Wagner, Kristi L., Bone graft materials containing calcium phosphate and chitosan.
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  4. Park, Hyun-Shin; Yu, Ji-Chul; Park, Ju-Hee; Kim, Jang-Hoon; Kim, Hun; Lee, Sae-Bom; Jang, Jae-Deog; Jang, Cheong-Ho, Composition for inducing tissue regeneration by activating platelet-rich plasma (PRP).
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  5. Shkolnik, Alexandr; El-Siblani, Ali; John, Hendrik, Continuous generative process for producing a three-dimensional object.
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  6. El-Siblani, Ali; Schillen, Volker; John, Hendrik, Device and method for producing a three-dimensional object by means of mask exposure.
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  7. John, Hendrik; Schillen, Volker; El-Siblani, Ali, Device and method for producing a three-dimensional object by means of mask exposure.
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  8. John, Hendrik; Schillen, Volker; El-Siblani, Ali, Device and method for producing a three-dimensional object by means of mask exposure.
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  9. Larsen, Kristian; Sabra, Mads, Device for promotion of hemostasis and/or wound healing.
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  10. Larsen, Kristian; Sabra, Mads, Device for promotion of hemostasis and/or wound healing.
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  11. Larsen, Kristian, Dry composition comprising an extrusion enhancer.
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  12. Larsen, Kristian, Dry haemostatic composition.
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  13. Larsen, Kristian, Dry haemostatic composition.
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  14. Sperry, Charles R.; McNamara, Jr., Dennis F.; Scott, Suzanne M.; Hull, Charles W.; Mojdeh, Mehdi, Elevator and method for tilting solid image build platform for reducing air entrainment and for build release.
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  15. Burkinshaw, Brian D.; Whitlock, Steven I.; Rogan, James B.; Devries, Gerald L., Enhanced biological autologous tissue adhesive composition and methods of preparation and use.
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  16. Conrad, Marissa M.; Valdes, Lauren S.; Morgan, Jenny E.; Bachert, Alice; Cohen, Abigail, Flowable collagen-based hemostat and methods of use.
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  17. Darmoc, Marissa M.; Brown, Lauren S.; Raynor, Jenny E.; Chou, Alice; Cohen, Abigail, Flowable collagen-based hemostat and methods of use.
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  18. Møller, Lene; Devantier, Kristina; Wulff, Trine; Sabra, Mads Christian, Haemostatic composition comprising hyaluronic acid.
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  19. Wolff, Jørgen, Haemostatic kit, a method of preparing a haemostatic agent and a method of promoting haemostasis.
    상세보기
  20. Gagnieu, Christian; Forest, Patricia; Picot, Sylvain, Hemostatic compositions.
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  21. Pauza, Kevin; Burkinshaw, Brian D.; Whitlock, Steven I.; Richards, Mark I.; Rogan, James B., Injection of fibrin sealant including an anesthetic in spinal applications.
    상세보기
  22. Pauza, Kevin; Burkinshaw, Brian D.; Whitlock, Steven I.; Richards, Mark I.; Rogan, James B., Injection of fibrin sealant including an anesthetic in spinal applications.
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  23. Burkinshaw, Brian D.; Whitlock, Steven I.; Pauza, Kevin; Richards, Mark I.; Rogan, James B., Injection of fibrin sealant using reconstituted components in spinal applications.
    상세보기
  24. Schillen, Volker; John, Hendrik; Siblani, Ali, Method and device for producing a three-dimensional object, and computer and data carrier useful therefor.
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  25. John, Hendrik; Schillen, Volker; El-Siblani, Ali, Method for producing a three-dimensional object by means of mask exposure.
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  26. Gettings, John A.; Havener, Matthew B.; McIlhenny, Stephen E., Mixing system and valve assembly.
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  27. Gettings, John A.; Havener, Matthew B.; McIlhenny, Stephen E., Mixing system and valve assembly.
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  28. Gettings, John A.; Havener, Matthew B.; McIlhenny, Stephen E., Mixing system and valve assembly.
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  29. Garigapati, Venkat R., Pepsinized collagen implants and biomedical uses thereof.
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  30. Garigapati, Venkat R., Pepsinized collagen implants and biomedical uses thereof.
    상세보기
  31. El-Siblani, Ali, Process and device for producing a three-dimensional object.
    상세보기
  32. El-Siblani, Ali, Process and device for producing a three-dimensional object.
    상세보기
  33. Schillen, Volker; El-Siblani, Ali, Process and device for producing a three-dimensional object.
    상세보기
  34. El-Siblani, Ali, Process and freeform fabrication system for producing a three-dimensional object.
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  35. El-Siblani, Ali, Process and freeform fabrication system for producing a three-dimensional object.
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  36. El-Siblani, Ali, Process and freeform fabrication system for producing a three-dimensional object.
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  37. El-Siblani, Ali; Shkolnik, Alexandr; John, Hendrik, Process for the production of a three-dimensional object with an improved separation of hardened material layers from a construction plane.
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  38. Shkolnik, Alexandr; John, Hendrik; El-Siblani, Ali, Process for the production of a three-dimensional object with an improved separation of hardened material layers from a construction plane.
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  39. Shkolnik, Alexandr; John, Hendrik; El-Sibiani, Ali, Process for the production of a three-dimensional object with resolution improvement by pixel-shift.
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  40. Shkolnik, Alexandr; John, Hendrik; El-Siblani, Ali, Process for the production of a three-dimensional object with resolution improvement by “pixel shift”.
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  41. Shkolnik, Alexandr; John, Hendrik; El-Siblani, Ali, Process for the production of a three-dimensional object with resolution improvement by “pixel-shift”.
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  42. El-Siblani, Ali; Shkolnik, Alexandr, Resin solidification substrate and assembly.
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  43. El-Siblani, Ali; Shkolnik, Alexandr, Resin solidification substrate and assembly.
    상세보기
  44. Garigapati, Venkat R., Stable compositions containing thrombin and methods for preparation and use thereof.
    상세보기
  45. Garigapati, Venkat R., Stable compositions containing thrombin and methods for preparation and use thereof.
    상세보기
  46. Jiang,Shan; Senderoff,Richard I.; Meyer,Jeffrey D., Thrombin compositions.
    상세보기
  47. Jiang,Shan; Senderoff,Richard I.; Meyer,Jeffrey D., Thrombin compositions.
    상세보기
  48. Larsen, Kristian; Mortensen, Michael Wrang, Vacuum expanded dry composition and syringe for retaining same.
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