Diarylsulfonylureas for use in treating secretory diarrhea
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-031/18
A61K-031/343
A61K-031/353
A61K-031/381
A61K-031/404.5
출원번호
US-0402874
(2000-01-31)
국제출원번호
PCT/US98/07295
(1998-04-10)
§371/§102 date
20000131
(20000131)
국제공개번호
WO-9844799
(1998-10-15)
발명자
/ 주소
Schultz Bruce D
출원인 / 주소
Eli Lilly and Company
대리인 / 주소
Gaylo
인용정보
피인용 횟수 :
13인용 특허 :
2
초록▼
This invention provides methods of treating secretory diarrhea or cystic fibrosis in a mammal which comprises administering to a mammal in need thereof an effective amount of diarylsulfonylurea. This invention also describes specific diarylsulfonylureas for use in treating secretory diarrhea or cyst
This invention provides methods of treating secretory diarrhea or cystic fibrosis in a mammal which comprises administering to a mammal in need thereof an effective amount of diarylsulfonylurea. This invention also describes specific diarylsulfonylureas for use in treating secretory diarrhea or cystic fibrosis.
대표청구항▼
[ What is claimed is:] [1.]1. A method of treating secretory diarrhea in a mammal which comprises administering to a mammal in need thereof a therapeutically effective amount of a compound of the formulaR.sup.1 is selected from the group consisting ofwherein:E is nitrogen, sulfur, or oxygen;where A
[ What is claimed is:] [1.]1. A method of treating secretory diarrhea in a mammal which comprises administering to a mammal in need thereof a therapeutically effective amount of a compound of the formulaR.sup.1 is selected from the group consisting ofwherein:E is nitrogen, sulfur, or oxygen;where A is --O--, --S(O).sub.n --, --CH.sub.2 S(O).sub.n --, --NR--, --CH.sub.2 --, --CH.sub.2 CH.sub.2 --, or --CH.sub.2 O--;D is --CH.sub.2 --, --S(O).sub.n --, --NR--, --CH.sub.2 S(O).sub.n --, or --O--;B is --CH.sub.2 --, --O--, --S(O).sub.n --, or --NR--;R is methyl or ethyl;n is 0-2;provided that at least one of A, B, and D is not --S(O).sub.n -- or --CH.sub.2 S(O).sub.n --; andR.sup.a, R.sup.b, and R.sup.c are independently selected from the group consisting of hydrogen, halo, C.sub.1 -C.sub.3 alkyl C.sub.1 -C.sub.3 alkoxy, and trifluoromethyl;or one of R.sup.a, R.sup.b, and R.sup.c is C.sub.2 -C.sub.8 alkenyl, another of R.sup.a, R.sup.b, and R.sup.c hydrogen or hydroxy, and the other of R.sup.a, R.sup.b, and R.sup.c is hydrogen;R.sup.4 and R.sup.5 are independently selected from the group consisting of hydrogen and C.sub.1 -C.sub.3 alkyl;R.sup.3 is hydrogen, halo, C.sub.1 -C.sub.3 alkyl, or trifluoromethyl; andR.sup.2 is halo, C.sub.1 -C.sub.3 alkyl, or trifluoromethyl; a pharmaceutically acceptable salt or solvate thereof.
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이 특허에 인용된 특허 (2)
Boder George B. (Martinsville IN) Ehlhardt William J. (Indianapolis IN) Grindey Gerald B. (Indianapolis IN) Toth John E. (Indianapolis IN) Worzalla John F. (Indianapolis IN) Zimmermann John L. (Green, Antitumor compositions and methods.
Welsh Michael J. (Riverside IA) Sheppard David N. (Coralville IA), Use of sulfonylureas and other potassium channel regulators to treat secretory diarrhea.
Russell, Michael Geoffrey Neil; Vater, Huw David; Macritchie, Jacqueline Anne; Doyle, Kevin James; Brown, David; Peach, Joanne, Cyclic and acyclic hydrazine derivatives compositions including them and uses thereof.
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