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Method of producing sub-micron particles of biologically active agents and uses thereof

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-009/50
  • B32B-005/16
  • B32B-015/02
  • B01J-013/02
  • B01J-013/04
출원번호 US-0422751 (1999-10-21)
발명자 / 주소
  • Costantino Henry R.
  • Jaworowicz Warren E.
  • Tracy Mark A.
  • Beganski Christopher P.
출원인 / 주소
  • Alkermes Controlled Therapeutics, Inc.
대리인 / 주소
    Hamilton, Brook, Smith & Reynolds, P.C.
인용정보 피인용 횟수 : 60  인용 특허 : 19

초록

Submicron particles of a biologically active agent are prepared by atomizing using multifluid atomization a dispersed system comprising at least one biologically active agent and at least one solvent to produce droplets, freezing the droplets to produce frozen droplets, lyophilizing the frozen dropl

대표청구항

[ What is claimed is:] [1.]1. A method for preparing submicron particles of a biologically active agent comprising the steps of:(a) atomizing using multifluid atomization a dispersed system comprising at least one biologically active agent and at least one solvent at a mass flow ratio of about 0.30

이 특허에 인용된 특허 (19)

  1. Fawzy Abdel A. (New Castle DE) Forestell Alferd J. (Newark DE), Apparatus and method for producing frozen particles of a liquid.
  2. Guiller ; Jacques, Apparatus for freezing small drops of liquid.
  3. Bartels Frank,DEX ; Bachtler Wulf,DEX ; Dunne Stephen Terence,GBX ; Eicher Joachim,DEX ; Freund Bernhard,DEX ; Hart William Barrie,GBX ; Lessmoellmann Christoph,DEX, Atomizing nozzle and filter and spray generating device.
  4. Tracy Mark A. ; Bernstein Howard ; Khan M. Amin, Composition and method for the controlled release of metal cation-stabilized interferon.
  5. Johnson OluFunmi Lily (Cambridge MA) Ganmukhi Medha M. (Wexford PA) Bernstein Howard (Cambridge MA) Auer Henry (Belmont MA) Khan M. Amin (Dowington PA), Composition for sustained release of human growth hormone.
  6. Zale Stephen E. (Hopkington MA) Burke Paul A. (Medford MA) Bernstein Howard (Cambridge MA) Brickner Avram (Brookline MA), Composition for sustained release of non-aggregated erythropoietin.
  7. Newton William A. (P.O. Box 161633 Miami FL 33116), Droplet exploding and freezing apparatus and method.
  8. Davis Robert B. (Nyack NY) DeVack Donald L. (Norwalk CT), Droplet freezing method and apparatus.
  9. Gibson Peter H. (Inkberrow GB2) Taylor Robert I. (Guildford GB2), Freezing a liquid.
  10. Fermani Nicholas R. (Newark DE) Fletcher Mark G. (Newark DE), Method and apparatus for producing frozen particles using an entrapment zone of atomized cryogenic liquid droplets.
  11. Imaike Sekiji (Osaka JPX) Hata Takeki (Kobe JPX) Yamazaki Norio (Itami JPX), Method and apparatus for producing microfine frozen particles.
  12. Oura Hiroyuki (Nara JPX) Hata Takeki (Hyogo JPX) Tada Masuo (Osaka JPX), Method and apparatus for producing microfine frozen particles.
  13. Burke Paul A., Method for fabricating polymer-based controlled-release devices.
  14. Bernstein Howard (Cambridge MA) Zhang Yan (Cambridge MA) Khan M. Amin (Downingtown PA) Tracy Mark A. (Arlington MA), Modulated release from biocompatible polymers.
  15. Bernstein Howard ; Zhang Yan ; Khan M. Amin ; Tracy Mark A., Modulated release from biocompatible polymers.
  16. Adams Thomas H. (Mission Viejo CA) Beck James P. (Garden Grove CA) Menson Robert C. (Newport Beach CA), Novel particulate compositions.
  17. Folan Michael Anthony,IEX, Process for drying a material from solution.
  18. Herbert Paul F. ; Healy Michael S., Production scale method of forming microparticles.
  19. Gibson Peter H. (Inkberrow GBX), Relating to freezing apparatus.

이 특허를 인용한 특허 (60)

  1. Pant, Abha; Bhatia, Inderdeep; Roy, Sunilendu Bhushan; Malik, Rajiv, Bioavailable dosage form of isotretinoin.
  2. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for administering compartmentalized frozen particles.
  3. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for administering compartmentalized frozen particles.
  4. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for administering compartmentalized frozen particles.
  5. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for administering compartmentalized frozen particles.
  6. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for biological remodeling with frozen particle compositions.
  7. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for biological remodeling with frozen particle compositions.
  8. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for biological remodeling with frozen particle compositions.
  9. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for biological remodeling with frozen particle compositions.
  10. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for biological remodeling with frozen particle compositions.
  11. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for biological remodeling with frozen particle compositions.
  12. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for delivery of frozen particle adhesives.
  13. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for delivery of frozen particle adhesives.
  14. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for delivery of frozen particle adhesives.
  15. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for delivery of frozen particle adhesives.
  16. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for surface abrasion with frozen particles.
  17. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for surface abrasion with frozen particles.
  18. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for surface abrasion with frozen particles.
  19. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for surface abrasion with frozen particles.
  20. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for surface abrasion with frozen particles.
  21. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for surface abrasion with frozen particles.
  22. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for surface abrasion with frozen particles.
  23. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for surface abrasion with frozen particles.
  24. Boyden, Edward S.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for therapeutic delivery with frozen particles.
  25. Boyden, Edward S.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for therapeutic delivery with frozen particles.
  26. Boyden, Edward S.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for therapeutic delivery with frozen particles.
  27. Boyden, Edward S.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for therapeutic delivery with frozen particles.
  28. Boyden, Edward S.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for therapeutic delivery with frozen particles.
  29. Boyden, Edward S.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for therapeutic delivery with frozen particles.
  30. Boyden, Edward S.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for therapeutic delivery with frozen particles.
  31. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Frozen compositions and array devices thereof.
  32. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Frozen compositions and methods for piercing a substrate.
  33. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Frozen compositions and methods for piercing a substrate.
  34. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Frozen compositions and methods for piercing a substrate.
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  36. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Frozen compositions and methods for piercing a substrate.
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  38. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Method and system for comparing tissue ablation or abrasion data to data related to administration of a frozen particle composition.
  39. Henry R. Costantino ; Warren E. Jaworowicz ; Mark A. Tracy ; Christopher P. Beganski, Method of producing sub-micron particles of biologically active agents and uses thereof.
  40. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Methods and systems for ablation or abrasion with frozen particles and comparing tissue surface ablation or abrasion data to clinical outcome data.
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  42. Batycky,Richard P.; Edwards,David A.; Lipp,Michael M., Particulate compositions for pulmonary delivery.
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  50. Wright, Steven G.; Christensen, Troy; Yeoh, Thean; Rickey, Michael E.; Hotz, Joyce M.; Kumar, Rajesh; Fineman, Mark; Smith, Christine; Ong, John; Lokensgard, David; Costantino, Henry R., Polymer-based sustained release device.
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  57. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Systems, devices, and methods for making or administering frozen particles.
  58. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Systems, devices, and methods for making or administering frozen particles.
  59. Ryles, Christine Watson; Williams, David Robert; Ziemkiewicz, Alexander George; Urbaez, Jesus Antonio, Zinc citrate beads in oral compositions.
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