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Methods for protection of nucleic acid sequences in urine

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C12P-019/34
  • C12Q-001/68
  • G01N-033/00
  • C07H-021/02
  • C07H-021/04
출원번호 US-0609162 (2000-07-03)
발명자 / 주소
  • Umansky Samuil R.
  • Lichtenstein Anatoly V.,RUX
  • Melkonyan Hovsep S.
출원인 / 주소
  • Diagen Corporation
대리인 / 주소
    Townsend and Townsend and Crew LLP
인용정보 피인용 횟수 : 37  인용 특허 : 1

초록

Described are non-invasive methods of detecting and/or quantifying specific nucleic acid sequences by analyzing urine samples for nucleic acids that have crossed the kidney barrier. More specifically, the present invention encompasses methods of analyzing specific fetal nucleic acid sequences by ana

대표청구항

[ We claim:] [1.]1. A method of detecting cancer in a patient, comprising:a) providing a urine sample from a patient; andb) analyzing said urine sample for a nucleic acid that (i) is from cells located outside the urinary tract, (ii) has crossed the kidney barrier, and (iii) contains a nucleic acid

이 특허에 인용된 특허 (1)

  1. Sorenson George D., Detection of soluble gene sequences in biological fluids.

이 특허를 인용한 특허 (37)

  1. Umansky, Samuil R.; Melkonyan, Hovsep S.; Shekhtman, Eugene M., Amplification and sequencing of transrenal nucleic acids.
  2. Fernando, Rohan M.; Ryan, Wayne L.; Hunsley, Brad, Compositions and methods for stabilizing circulating tumor cells.
  3. H. Ralph Snodgrass ; Joseph Cioffi ; Thomas Joel Zupancic ; Alan Wayne Shafer, Detection of a leptin receptor variant and methods for regulating obesity.
  4. Fernando, M. Rohan, Devices and compositions for preservation of cell-free nucleic acids.
  5. Busse, Ursula; Chypre, Camille; Fradet, Yves, Distinguishing PCA3 messenger RNA species in benign and malignant prostate tissues.
  6. Busse, Ursula; Chypre, Camille; Fradet, Yves, Distinguishing PCA3 messenger RNA species in benign and malignant prostate tissues.
  7. Busse, Ursula; Chypre, Camille; Fradet, Yves, Distinguishing PCA3 messenger RNA species in benign and malignant prostate tissues.
  8. Fraser,Christopher C., FAIL molecules and uses thereof.
  9. Chiu,Allen W.; Huang,Yu Lun; Chou,Chen Kung, HURP gene as a molecular marker for bladder cancer.
  10. Haga,Tatsuya; Okuda,Takashi, High-affinity choline transporter.
  11. Haga,Tatsuya; Okuda,Takashi, High-affinity choline transporter.
  12. Ryan, Wayne L.; Grunkemeyer, James A, Inactivated virus compositions and methods of preparing such compositions.
  13. Melkonyan, Hovsep; Cannas, Angela; Tomei, Louis David; Umansky, Samuil R., Kits for diagnosis and monitoring of pathogenic infection by analysis of cell-free pathogenic nucleic acids in urine.
  14. Melkonyan, Hovsep; Cannas, Angela; Tomei, Louis David; Umansky, Samuil R., Kits for diagnosis and monitoring of viral infection by analysis of viral transrenal nucleic acids in urine.
  15. Jiang, Fuman; Chen, Huifei; Chai, Xianghua; Yuan, Yuying; Zhang, Xiuqing; Chen, Fang, Method for determining fetal chromosomal abnormality.
  16. Melkonyan, Hovsep; Cannas, Angela; Tomei, Louis David; Umansky, Samuil R., Method for diagnosis and monitoring of viral infection by analysis of viral transrenal nucleic acids in urine.
  17. McMillian,Ray A., Method for preservation of cells and nucleic acid targets.
  18. Fradet, Yves; Chypre, Camille; Piche, Lyson; Garon, Genevieve, Method to detect prostate cancer in a sample.
  19. Fradet, Yves; Chypre, Camille; Piché, Lyson; Garon, Geneviève, Method to detect prostate cancer in a sample.
  20. Fradet, Yves; Chypre, Camille; Piché, Lyson; Garon, Geneviéve, Method to detect prostate cancer in a sample.
  21. Umansky,Samuil R.; Lichtenstein,Anatoly V.; Melkonyan,Hovsep S., Methods for detection of nucleic acid sequences in urine.
  22. Fernando, M. Rohan, Methods for preservation of cell-free nucleic acids.
  23. Freije,Wadiha; Brikun,Igor, Methods of copying the methylation pattern of DNA during isothermal amplification and microarrays.
  24. Umansky, Samuil R.; Melkonyan, Hovsep S.; Scheinker, Vladimir S., Methods of detecting cell-free miRNA in urine and blood.
  25. Doucette Stamm,Lynn; Bush,David, Nucleic acid and amino acid sequences relating tofor diagnostics and therapeutics.
  26. Bussemakers, Marion J. G.; Isaacs, William B., PCA3 genes.
  27. Busse, Ursula; Chypre, Camille; Fradet, Yves, PCA3 messenger RNA species in benign and malignant prostate tissues.
  28. Bussemakers, Marion J. G.; Isaacs, William B., PCA3, PCA3 genes, and methods of use.
  29. Goddard,Audrey; Godowski,Paul J.; Gurney,Austin L.; Wood,William I., PRO354 antibodies.
  30. Fernando, M. Rohan, Preservation of cell-free RNA in blood samples.
  31. Fernando, M. Rohan, Preservation of cell-free RNA in blood samples.
  32. Fernando, M. Rohan, Preservation of cell-free RNA in blood samples.
  33. Fernando, M. Rohan, Preservation of cell-free nucleic acids.
  34. Hessels, Daphne; Verhaegh, Gerald; Schalken, Jack A.; Witjes, J. Alfred, Prostate cancer prognostic compositions and kits.
  35. Hessels, Daphne; Verhaegh, Gerald; Schalken, Jack A.; Witjes, J. Alfred, Prostate cancer prognostic compositions and kits.
  36. Baker, Tony, Removal of molecular assay interferences.
  37. Hessels, Daphne; Verhaegh, Gerald; Schalken, Jack A.; Witjes, Alfred J., mRNA ratios in urinary sediments and/or urine as a prognostic and/or theranostic marker for prostate cancer.
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