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Emulsion-based processes for making microparticles

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-009/16
  • B01J-013/12
출원번호 US-0303842 (1999-05-03)
발명자 / 주소
  • Gibson John W.
  • Holl Richard J.
  • Tipton Arthur J.
출원인 / 주소
  • Southern BioSystems, Inc.
대리인 / 주소
    Holland & Knight LLP
인용정보 피인용 횟수 : 120  인용 특허 : 19

초록

Processes for making microparticles, preferably containing an active agent, are provided. In a preferred embodiment, the process involves preparing (1) a dispersed phase containing an agent in a solution of polymer and a first solvent; (2) a continuous phase containing a surfactant, a second solvent

대표청구항

[ We claim:] [1.]1. A method for making microparticles, the method comprising(a) preparing a first phase comprising a solution of an excipient dissolved in a first solvent;(b) preparing a second phase comprising a second solvent which is at least partially soluble in the first solvent;(c) preparing

이 특허에 인용된 특허 (19)

  1. Patil Deepak R. (Livingston NJ) VanBuskirk Glenn A. (Bernardsville NJ), Continuous process for the preparation of semisolid dispersions.
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  10. Mathiowitz Edith ; Langer Robert S., Multiwall polymeric microspheres.
  11. DeLuca Patrick P. (Lexington KY) Kanke Motoko (Fukuyama JPX) Sato Toyomi (Tokyo CA JPX) Schroeder Hans G. (Encinitas CA), Porous microspheres for drug delivery and methods for making same.
  12. Herbert Paul F. (Wayland MA) Hazrati Azar M. (Maineville OH), Preparation of biodegradable microparticles containing a biologically active agent.
  13. Ramstack J. Michael (Lebanon OH) Herbert Paul F. (Wayland MA) Strobel Jan (Westchester OH) Atkins Thomas J. (Cincinnati OH), Preparation of biodegradable microparticles containing a biologically active agent.
  14. Rickey Michael E. ; Ramstack J. Michael ; Lewis Danny H., Preparation of biodegradable, biocompatible microparticles containing a biologically active agent.
  15. Rickey Michael E. ; Ramstack J. Michael ; Lewis Danny H. ; Mesens Jean,BEX, Preparation of extended shelf-life biodegradable, biocompatible microparticles containing a biologically active agent.
  16. Wantier Henri (Dour BEX) Mathieu Fabienne (Nivelles BEX) Baudrihaye Marc (Waterloo BEX) Delacroix Dominique (Kraainem BEX), Preparation of microparticles for controlled release of water-soluble substances.
  17. Fong, Jones W., Process for preparation of microspheres.
  18. Ferraris Mario (Novara ITX) Rosati Francesco (Milan ITX), Process for preparing spheroidally shaped products, solid at room temperature.
  19. Herbert Paul F. ; Healy Michael S., Production scale method of forming microparticles.

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