초록 ▼

A method for sampling of a substance from a subject is provided, which comprises placing one or more sampling chambers on a collection site on a tissue surface on the subject; conducting electric current through the tissue to extract a substance from the subject in a first direction in one or more s

A method for sampling of a substance from a subject is provided, which comprises placing one or more sampling chambers on a collection site on a tissue surface on the subject; conducting electric current through the tissue to extract a substance from the subject in a first direction in one or more sampling chambers that functions alternatively as both an anode and cathode during the course of the method; reversing the polarity to cause direct current to flow in second direction opposite the first direction; and analyzing the sampling chamber or chambers for the concentration of a substance or a substance metabolite. There is also provided a device for sampling of a substance from an organism on continuously or intermittently using alternating polarity method based on the application of low intensity electric fields of alternating polarity across the skin (iontophoresis) to enhance the transport of a substance (such as glucose, lactic acid, pyruvic acid, and the like) from body tissues to a sampling chamber. The device comprises an electrical power supply; a transdermal system that contains one or more sampling chambers that function as both anode and cathode during the course of sampling; a means to alternates or reverses the polarity during the iontophoretic sampling; and means for analyzing for the concentration of a substance or a substance metabolite.

대표청구항 ▼

[ What is claimed is:] [1.]1. A method for sampling of at least one substance from a subject which comprises:(a) conducting electrical current in a first polarity through a tissue of the subject, said conducting in a first polarity from a first sampling chamber on a surface of the tissue to a second

[ What is claimed is:] [1.]1. A method for sampling of at least one substance from a subject which comprises:(a) conducting electrical current in a first polarity through a tissue of the subject, said conducting in a first polarity from a first sampling chamber on a surface of the tissue to a second sampling chamber on the surface of the tissue to extract a substance from the subject into the first sampling chamber;(b) conducting electrical current in a second polarity through a tissue of the subject, said conducting in a second polarity from the second sampling chamber to the first sampling chamber to extract the substance from the subject into the second sampling chamber; and(c) analyzing each sampling chamber for a concentration or amount of the substance.