초록 ▼

A device is prepared having cells or tissue attached to a non-degradable filamentous matrix surrounded by a semi-permeable membrane. The matrix is preferably formed of a plurality of monofilaments twisted into a yarn or woven into a mesh, and can be in the form of a cylinder. When implanting the dev

A device is prepared having cells or tissue attached to a non-degradable filamentous matrix surrounded by a semi-permeable membrane. The matrix is preferably formed of a plurality of monofilaments twisted into a yarn or woven into a mesh, and can be in the form of a cylinder. When implanting the device, the semi-permeable membrane is preferably immunolsolatory, and the cells or tissue may produce a biologically active molecule to provide therapy. To enhance cell or tissue adhesion, the matrix is coated with extracellular matrix molecules or treated to provide a surface charge. The device can be made by inserting the matrix into a capsule formed of the semi-permeable membrane, distributing the cells or tissue on the matrix through an opening of the capsule, and sealing the opening of the capsule.

대표청구항 ▼

[ We claim:] [1.]1. A device containing encapsulated cells or tissue for implanting into a host comprising:(a) a substantially non-degradable filamentous cell-supporting matrix, wherein the matrix comprises a plurality of monofilaments, and wherein said monofilaments are twisted into a yarn or woven

[ We claim:] [1.]1. A device containing encapsulated cells or tissue for implanting into a host comprising:(a) a substantially non-degradable filamentous cell-supporting matrix, wherein the matrix comprises a plurality of monofilaments, and wherein said monofilaments are twisted into a yarn or woven into a mesh, and the cells or tissue are distributed thereon; and(b) a semi-permeable encapsulating membrane surrounding the matrix.