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Encapsulation of bioactive agents 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • B01J-013/02
  • B01J-013/04
  • B01J-013/20
  • B05D-007/00
출원번호 US-0310936 (1999-05-13)
우선권정보 GB0010236 (1998-05-13)
발명자 / 주소
  • Farrar Graham Henry,GBX
  • Tinsley-Bown Anne Margaret,GBX
  • Jones David Hugh,CAX
출원인 / 주소
  • Microbiological Research Authority, GBX
대리인 / 주소
    Fish & Richardson P.C.
인용정보 피인용 횟수 : 41  인용 특허 : 30

초록 ▼

Bioactive agent is encapsulated in a polymer microparticle in a (water-in-oil)-in-water emulsion-based method, and using a solvent that comprises ethyl acetate. Also described are microparticles comprising low inherent viscosity (i.v.) PLG, some with i.v. less than 0.5dl/g, and methods for their pre

대표청구항 ▼

[ What is claimed is:] [1.]1. A method for encapsulating DNA in a polymer microparticle, comprising:dissolving polymer in a solvent to form a polymer solution;preparing an aqueous solution of DNA;combining the polymer and aqueous solutions with agitation to form a water-in-oil emulsion;adding the wa

이 특허에 인용된 특허 (30)

  1. DeLuca Patrick P. (Lexington KY) Rypacek Frantisek (Leckova CSX), Biodegradable microspheres as a carrier for macromolecules.
    상세보기
  2. Nuwayser Elie S. (Wellesley MA) Nucefora William A. (Bedford MA), Controlled release composite core coated microparticles.
    상세보기
  3. Ludwig Nelson H. (Greenfield IN) Ose Earl E. (Greenfield IN), Controlled release formulations and method of treatment.
    상세보기
  4. Hess Joachim (Bingen DEX) Mller Klaus R. (Ingelheim am Rhein DEX), Copolymers of lactic acid and tartaric acid, the production and the use thereof.
    상세보기
  5. Felgner Philip L. (Rancho Santa Fe CA) Wolff Jon A. (Madison WI) Rhodes Gary H. (Leucadia CA) Malone Robert W. (Chicago IL) Carson Dennis A. (Del Mar CA), Delivery of exogenous DNA sequences in a mammal.
    상세보기
  6. Tice Thomas R. (Birmingham AL) Gilley Richard M. (Birmingham AL), Drug delivery system and method of making the same.
    상세보기
  7. Felgner Philip L. (Rancho Santa Fe CA) Wolff Jon A. (Madison WI) Rhodes Gary H. (Leucadia CA) Malone Robert W. (Chicago IL) Carson Dennis A. (Del Mar CA), Induction of a protective immune response in a mammal by injecting a DNA sequence.
    상세보기
  8. Tice Thomas R. ; Gilley Richard M. ; Eldridge John H. ; Staas Jay K., Method for delivering bioactive agents into and through the mucosally associated lymphoid tissues and controlling their.
    상세보기
  9. Tice Thomas R. ; Gilley Richard M. ; Eldridge John H. ; Staas Jay K., Method for delivering bioactive agents into and through the mucosally-associated lymphoid tissues and controlling their.
    상세보기
  10. Tresco Patrick A. (Salt Lake City UT) Mills John F. (Wakefield RI), Method of encapsulating biological substances in microspheres.
    상세보기
  11. Tice Thomas R. (Birmingham AL) Gilley Richard M. (Birmingham AL) Eldridge John H. (Birmingham AL) Staas Jay K. (Birmingham AL) Hollingshead Melinda G. (Birmingham AL) Shannon William M. (Birmingham A, Method of potentiating an immune response.
    상세보기
  12. Grinstaff Mark W. (Pasadena CA) Soon-Shiong Patrick (Los Angeles CA) Wong Michael (Champaign IL) Sandford Paul A. (Los Angeles CA) Suslick Kenneth S. (Champaign IL) Desai Neil P. (Los Angeles CA), Methods for the preparation of nucleic acids for in vivo delivery.
    상세보기
  13. Tice Thomas R. (Birmingham AL) Gilley Richard M. (Birmingham AL), Microencapsulation process and products therefrom.
    상세보기
  14. Hedley Mary Lynne ; Curley Joanne M. ; Langer Robert S., Microparticles for delivery of nucleic acid.
    상세보기
  15. Hunter Robert L. (Tucker GA) Bennett Carol E. (Decatur GA), Multiple emulsions and methods of preparation.
    상세보기
  16. Landh Tomas (Lund SEX) Larsson Kare (Bjrred SEX), Particles, method of preparing said particles and uses thereof.
    상세보기
  17. Hyon Suong-Hyu (Uji JPX) Ikada Yoshita (Uji JPX), Polylactic acid type microspheres containing physiologically active substance and process for preparing the same.
    상세보기
  18. Yeh Ming-Kung,TWX ; Coombes Alan Gerald,GBX ; Jenkins Paul George,GBX ; Davis Stanley Stewart,GBX, Polymer microparticles for drug delivery.
    상세보기
  19. DeLuca Patrick P. (Lexington KY) Kanke Motoko (Fukuyama JPX) Sato Toyomi (Tokyo CA JPX) Schroeder Hans G. (Encinitas CA), Porous microspheres for drug delivery and methods for making same.
    상세보기
  20. Herbert Paul F. (Wayland MA) Hazrati Azar M. (Maineville OH), Preparation of biodegradable microparticles containing a biologically active agent.
    상세보기
  21. Ramstack J. Michael (Lebanon OH) Herbert Paul F. (Wayland MA) Strobel Jan (Westchester OH) Atkins Thomas J. (Cincinnati OH), Preparation of biodegradable microparticles containing a biologically active agent.
    상세보기
  22. De Luca Patrick P. (Lexington KY) Rypacek Frantisek (Leckova CZX), Preparation of biodegradable microspheres useful as carriers for macromolecules.
    상세보기
  23. Fong Jones W. (Parsippany NJ), Process for preparation of microspheres.
    상세보기
  24. Billot Genevieve B. (Lyons FRX) Teichner Marc M. (Sainte Foy Les Lyon FRX), Process for preparing microspheres for the prolonged release of the LHRH hormone and its analogues, microspheres and for.
    상세보기
  25. Okada Hiroaki (Suita JPX) Ogawa Yasuaki (Ibaraki JPX) Yashiki Takatsuka (Takarazuka JPX), Prolonged release microcapsule and its production.
    상세보기
  26. Okada Hiroaki (Osaka JPX) Ogawa Yasuaki (Osaka JPX) Yashiki Takatsuka (Hyogo JPX), Prolonged release microcapsule of a water-soluble drug.
    상세보기
  27. Okada Hiroaki (Osaka JPX) Ogawa Yasuaki (Osaka JPX) Yashiki Takatsuka (Hyogo JPX), Prolonged release microcapsules.
    상세보기
  28. Okada Hiroaki (Osaka JPX) Ogawa Yasuaki (Osaka JPX) Yashiki Takatsuka (Hyogo JPX), Prolonged release microcapsules and their production.
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  29. Machida Minoru (Tokyo JPX) Arakawa Masayuki (Shizuoka JPX), Sustained-release particulate preparation and process for preparing the same.
    상세보기
  30. Reid Robert H. (Kensington MD) Boedeker Edgar C. (Chevy Chase MD) van Hamont John E. (Shape MD BEX) Setterstrom Jean A. (Takoma Park MD), Vaccines against diseases caused by enteropathogenic organisms using antigens encapsulated within biodegradable-biocompa.
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