[특허]Controlled local delivery of chemotherapeutic agents for treating solid tumors

Controlled local delivery of chemotherapeutic agents for treating solid tumors 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61K-009/14 A61K-009/50
출원번호	US-0363519 (1999-07-29)
발명자 / 주소	Brem Henny Langer Robert S. Domb Abraham J.,ILX
출원인 / 주소	The Johns Hopkins University
대리인 / 주소	Holland & Knight LLP
인용정보	피인용 횟수 : 22 인용 특허 : 74

초록 ▼

A method and devices for localized delivery of a chemotherapeutic agent to solid tumors, wherein the agent does not cross the blood-brain barrier and is characterized by poor bioavailability and/or short half-lives in vivo, are described. The devices consist of reservoirs which release drug over an extended time period while at the same time preserving the bioactivity and bioavailability of the agent. In the most preferred embodiment, the device consists of biodegradable polymeric matrixes, although reservoirs can also be formulated from non-biodegradable polymers or reservoirs connected to implanted infusion pumps. The devices are implanted within or immediately adjacent the tumors to be treated or the site where they have been surgically removed. The examples demonstrate the efficacy of paclitaxel and camptothecin delivered in polymeric implants prepared by compression molding of biodegradable and non-biodegradable polymers, respectively. The results are highly statistically significant.

대표청구항 ▼

[ We claim:] [1.]1. A chemotherapeutic composition comprisinga biocompatible synthetic polymeric matrix incorporatingan effective amount to inhibit tumor growth when released in vivo at the site of the tumor of a water insoluble, relatively lipid insoluble chemotherapeutic agent,wherein the chemotherapeutic agent is incorporated into an released from a synthetic polymeric matrix by degradation of the polymer matrix or diffusion of the agent out of the matrix over a period of time of at least eight hours. [53.]53. The composition of claim 51 wherein the compound is adriamycin and the cytokine is interleukin 2..Iaddend..Iadd.

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Controlled local delivery of chemotherapeutic agents for treating solid tumors 원문보기

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