초록 ▼

A process and product comprising collagen and demineralized bone particles. The product may contain a maximum of 20% by weight inorganic materials. The product may densified by compression. Additional osteogenic factors, mitogens, drugs or antibiotics may be incorporated therein. Inorganic materials

A process and product comprising collagen and demineralized bone particles. The product may contain a maximum of 20% by weight inorganic materials. The product may densified by compression. Additional osteogenic factors, mitogens, drugs or antibiotics may be incorporated therein. Inorganic materials may be bound to the organic matrix via precoating with a calcium or hydroxyapatite binding protein, peptide or amino acid. The materials also display long lasting drug release characteristics.

대표청구항 ▼

[ What is claimed is:] [1.]1. A method of making a biocompatible, osteogenic bone repair composition, said method comprising:a) dispersing a plurality of osteoinductive protein based particles in an aqueous solution of about 0.002 to about 0.25 weight percent of a crosslinking agent and surface acti

[ What is claimed is:] [1.]1. A method of making a biocompatible, osteogenic bone repair composition, said method comprising:a) dispersing a plurality of osteoinductive protein based particles in an aqueous solution of about 0.002 to about 0.25 weight percent of a crosslinking agent and surface activating or partially crosslinking said particles, said protein-based particles selected from the group consisting of demineralized bone matrix, mixtures of demineralized bone matrix and collagen, demineralized bone matrix extracted with a chaotropic agent and complexed with bone morphogenetic protein, reconstituted collagen complexed with bone morphogenctic protein, or mixtures of demineralized bone matrix extracted with a chaotropic agent and collagen complexed with bone morphogenetic protein; andb) removing the particles of step (a) from the aqueous solution; andc) milling the particles of step (b) into a powder.